Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 1899926)

Published in Mol Cell Biol on February 05, 2007

Authors

Mary A Braun1, Patrick J Costa, Elia M Crisucci, Karen M Arndt

Author Affiliations

1: Department of Biological Sciences, University of Pittsburgh, 269 Crawford Hall, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA.

Articles citing this

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature (2010) 2.47

The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states. Biochim Biophys Acta (2012) 1.32

A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism. Genetics (2007) 1.26

A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation. J Biol Chem (2009) 0.98

Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae. Genetics (2011) 0.95

Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation. Semin Cell Dev Biol (2012) 0.88

The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae. PLoS Genet (2015) 0.87

Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins. J Biol Chem (2015) 0.82

Spt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae. Eukaryot Cell (2010) 0.81

The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae. Genetics (2012) 0.79

Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. J Biol Chem (2015) 0.78

Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae. G3 (Bethesda) (2013) 0.78

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation. PLoS One (2011) 0.77

Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast. G3 (Bethesda) (2016) 0.76

Articles cited by this

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71

Global analysis of protein localization in budding yeast. Nature (2003) 33.22

Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87

Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol (1991) 16.88

Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol (2002) 13.78

Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78

SUMO: a history of modification. Mol Cell (2005) 10.40

Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C. Yeast (1995) 9.80

Fluorescence microscopy methods for yeast. Methods Cell Biol (1989) 9.68

Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem (2006) 8.66

Histone modifications in transcriptional regulation. Curr Opin Genet Dev (2002) 8.10

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A (1999) 7.32

The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae. Annu Rev Biochem (2003) 7.22

The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci (1995) 6.97

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell (2000) 6.81

Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev (2001) 6.28

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53

Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A (1995) 5.37

A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature (2005) 5.13

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04

How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol (2003) 4.90

Rad6-dependent ubiquitination of histone H2B in yeast. Science (2000) 4.68

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol (2000) 4.53

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49

Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol Cell (2002) 4.35

A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell (2003) 4.04

Recruitment of a 19S proteasome subcomplex to an activated promoter. Science (2002) 4.01

GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem Sci (1997) 3.87

Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell (2005) 3.82

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81

Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77

The PHD finger, a nuclear protein-interaction domain. Trends Biochem Sci (2005) 3.56

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. EMBO J (2002) 3.44

The proteasome: a utility tool for transcription? Curr Opin Genet Dev (2006) 3.29

Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J (2003) 3.26

Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol (2005) 3.20

Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem (2002) 3.14

A review of phenotypes in Saccharomyces cerevisiae. Yeast (1997) 3.10

Degradation-mediated protein quality control in the nucleus. Cell (2005) 3.10

The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem (2003) 3.08

Histone H3 Lys 4 methylation: caught in a bind? Genes Dev (2006) 2.86

The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell (2005) 2.75

The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators. Cell (2005) 2.71

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex. Mol Cell Biol (2002) 2.60

Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem (2006) 2.45

The Paf1 complex has functions independent of actively transcribing RNA polymerase II. Mol Cell (2004) 2.31

A putative stimulatory role for activator turnover in gene expression. Nature (2005) 2.28

Ribosomal protein L32 of Saccharomyces cerevisiae influences both the splicing of its own transcript and the processing of rRNA. Mol Cell Biol (1997) 2.24

Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. Genetics (2000) 2.22

Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Mol Cell (2004) 2.20

Isolation and analysis of a novel class of suppressor of Ty insertion mutations in Saccharomyces cerevisiae. Genetics (1988) 2.20

SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae. Genes Dev (2006) 2.16

Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15

A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets. Mol Cell (2005) 2.14

A field guide to ubiquitylation. Cell Mol Life Sci (2004) 2.09

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Mol Cell (2005) 2.05

The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell (2005) 1.94

Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell (2005) 1.93

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Biochem J (2005) 1.84

Global synthetic-lethality analysis and yeast functional profiling. Trends Genet (2005) 1.82

Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nat Cell Biol (2003) 1.79

Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin. J Biol Chem (2004) 1.78

Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae. Mol Cell Biol (1997) 1.76

Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism. Mol Genet Genomics (2002) 1.67

Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I. Proc Natl Acad Sci U S A (1997) 1.64

SPT10 and SPT21 are required for transcription of particular histone genes in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.51

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain. J Biol Chem (2004) 1.50

Proteolytic turnover of the Gal4 transcription factor is not required for function in vivo. Nature (2006) 1.49

The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem (2006) 1.43

The SPT10 and SPT21 genes of Saccharomyces cerevisiae. Genetics (1994) 1.25

Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol Cell (2005) 1.22

DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.18

Global regulation by the yeast Spt10 protein is mediated through chromatin structure and the histone upstream activating sequence elements. Mol Cell Biol (2005) 1.18

The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter. Genetics (2005) 1.07

Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem (2004) 1.06

Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21. Mol Cell Biol (2004) 1.03

Evidence that Spt10 and Spt21 of Saccharomyces cerevisiae play distinct roles in vivo and functionally interact with MCB-binding factor, SCB-binding factor and Snf1. Genetics (2005) 0.91

A novel yeast genomic DNA library on a geneticin-resistance vector. Yeast (2005) 0.87

Articles by these authors

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. EMBO J (2002) 3.44

Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J (2003) 3.26

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Mol Cell (2005) 2.05

Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes. EMBO J (2007) 1.73

Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem (2007) 1.42

Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification. Mol Cell Biol (2007) 1.40

The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states. Biochim Biophys Acta (2012) 1.32

The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter. Genetics (2005) 1.07

Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast. Proc Natl Acad Sci U S A (2012) 0.95

Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae. Genetics (2011) 0.95

A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem (2008) 0.92

Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proc Natl Acad Sci U S A (2013) 0.91

The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genet Res Int (2011) 0.90

Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin. J Biol Chem (2012) 0.90

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation. Mol Cell Biol (2012) 0.85

The recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex. Mol Cell Biol (2013) 0.85

Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter. Mol Cell Biol (2012) 0.85

The Paf1 complex represses ARG1 transcription in Saccharomyces cerevisiae by promoting histone modifications. Eukaryot Cell (2011) 0.84

A TATA binding protein mutant with increased affinity for DNA directs transcription from a reversed TATA sequence in vivo. Mol Cell Biol (2002) 0.79

The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae. Genetics (2012) 0.79

Molecular biology: genome under surveillance. Nature (2007) 0.75