Published in J Biol Chem on March 06, 2007
Structure and mechanism of a Na+-independent amino acid transporter. Science (2009) 3.30
Comparative genomic analysis of T-box regulatory systems in bacteria. RNA (2008) 1.75
Pathophysiology and treatment of cystinuria. Nat Rev Nephrol (2010) 1.40
Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily. J Biol Chem (2008) 1.19
An in silico analysis of T-box regulated genes and T-box evolution in prokaryotes, with emphasis on prediction of substrate specificity of transporters. BMC Genomics (2008) 1.11
The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. J Struct Biol (2016) 0.96
A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). J Biol Chem (2009) 0.92
Novel SLC7A7 large rearrangements in lysinuric protein intolerance patients involving the same AluY repeat. Eur J Hum Genet (2008) 0.91
Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter. J Biol Chem (2009) 0.89
Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiT. Proc Natl Acad Sci U S A (2013) 0.88
Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc. Proc Natl Acad Sci U S A (2014) 0.86
Molecular mechanism of pH-dependent substrate transport by an arginine-agmatine antiporter. Proc Natl Acad Sci U S A (2014) 0.81
A putative amino acid transporter determines sensitivity to the two-peptide bacteriocin plantaricin JK. Microbiologyopen (2016) 0.78
Role of transmembrane domain 8 in substrate selectivity and translocation of SteT, a member of the L-amino acid transporter (LAT) family. J Biol Chem (2010) 0.78
Stabilization of a prokaryotic LAT transporter by random mutagenesis. J Gen Physiol (2016) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Enterotypes of the human gut microbiome. Nature (2011) 24.36
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science (2002) 9.43
PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments. Nucleic Acids Res (2006) 8.36
Mitochondrial dynamics in mammalian health and disease. Physiol Rev (2009) 3.59
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45
Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science (2008) 3.39
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
The DNA sequence of human chromosome 7. Nature (2003) 3.18
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature (2012) 2.88
The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet (2005) 2.72
Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J (2005) 2.64
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science (2010) 2.52
Overcoming barriers to membrane protein structure determination. Nat Biotechnol (2011) 2.49
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. EMBO J (2010) 2.05
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A (2012) 2.00
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells. Blood (2006) 1.92
Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes (2006) 1.91
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem J (2002) 1.87
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci (2002) 1.79
Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J Am Soc Nephrol (2002) 1.73
Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene (2003) 1.73
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68
The structure of cbb3 cytochrome oxidase provides insights into proton pumping. Science (2010) 1.68
Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J (2013) 1.65
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci (2011) 1.65
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem (2004) 1.64
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res (2007) 1.63
Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ Res (2006) 1.63
dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr Biol (2010) 1.62
Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol Sci (2006) 1.60
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
Domain compliance and elastic power transmission in rotary F(O)F(1)-ATPase. Proc Natl Acad Sci U S A (2008) 1.57
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers. Clin Cancer Res (2002) 1.55
The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Rev (2007) 1.50
Comparison between two high-dose methylprednisolone schedules in the treatment of acute hepatic cellular rejection in liver transplant recipients: a controlled clinical trial. Liver Transpl (2002) 1.50
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One (2008) 1.50
Molecular architecture of photosynthetic membranes in Rhodobacter sphaeroides: the role of PufX. EMBO J (2004) 1.47
Determining promoter location based on DNA structure first-principles calculations. Genome Biol (2007) 1.44
Mitochondrial fusion proteins: dual regulators of morphology and metabolism. Semin Cell Dev Biol (2010) 1.44
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care (2009) 1.42
Pathophysiology and treatment of cystinuria. Nat Rev Nephrol (2010) 1.40
Functional and structural characterization of rhodopsin oligomers. J Biol Chem (2006) 1.39
Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes (2002) 1.38
The transition state for folding of an outer membrane protein. Proc Natl Acad Sci U S A (2010) 1.37
Molecular basis of substrate-induced permeation by an amino acid antiporter. Proc Natl Acad Sci U S A (2011) 1.37
Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem (2005) 1.36
The supramolecular assemblies of voltage-dependent anion channels in the native membrane. J Mol Biol (2007) 1.36
The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med (2013) 1.36
The hydantoin transport protein from Microbacterium liquefaciens. J Bacteriol (2006) 1.32
Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. Int J Biochem Cell Biol (2009) 1.32
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem (2003) 1.31
PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Cell Metab (2010) 1.29
Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Sci Signal (2013) 1.29
Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. Endocrinology (2009) 1.26
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene (2005) 1.25
Design, synthesis, and reactivity of 1-hydrazinodienes for use in organic synthesis. J Am Chem Soc (2005) 1.24
The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol (2005) 1.23
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol (2013) 1.23
Reconstitution of water channel function of an aquaporin overexpressed and purified from Pichia pastoris. FEBS Lett (2003) 1.21
Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily. J Biol Chem (2008) 1.19
Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole. J Biol Chem (2001) 1.18
The genetics of heteromeric amino acid transporters. Physiology (Bethesda) (2005) 1.18
Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts. Hum Mol Genet (2004) 1.18
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res (2013) 1.18
Expression, purification and characterisation of full-length histidine protein kinase RegB from Rhodobacter sphaeroides. J Mol Biol (2002) 1.17
Evidence for transcript networks composed of chimeric RNAs in human cells. PLoS One (2012) 1.16
Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis. Hum Mol Genet (2003) 1.15
Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. J Immunol (2006) 1.15
The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. EMBO Rep (2009) 1.14