Published in Proc Natl Acad Sci U S A on February 01, 1992
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82
Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65
A severe combined immunodeficiency mutation in the mouse. Nature (1983) 13.99
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature (1986) 9.63
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science (1988) 9.05
Production of hybridoma growth factor by human monocytes. Eur J Immunol (1987) 7.99
Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell (1985) 6.88
Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature (1988) 6.38
Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proc Natl Acad Sci U S A (1987) 5.68
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature (1988) 5.60
Biological and clinical aspects of interleukin 6. Immunol Today (1990) 5.17
Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature (1984) 5.10
Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells. J Immunol (1981) 4.27
IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J (1987) 3.64
A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT. Proc Natl Acad Sci U S A (1983) 3.31
Human immunodeficiency virus infection of human-PBL-SCID mice. Science (1991) 2.77
Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci U S A (1987) 2.76
Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J Immunol (1989) 2.27
Progress toward human gene therapy. Science (1989) 2.26
Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man. J Exp Med (1991) 2.20
Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent. J Virol (1989) 1.86
Engraftment of immune-deficient mice with human hematopoietic stem cells. Science (1988) 1.85
Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J Exp Med (1989) 1.77
Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer. Proc Natl Acad Sci U S A (1986) 1.70
Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med (1991) 1.62
A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science (1989) 1.60
Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 1.59
Expression of human adenosine deaminase in mice reconstituted with retrovirus-transduced hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 1.49
Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses. Mol Biol Med (1987) 1.42
Antitumor activity of recombinant interleukin 6 in mice. J Exp Med (1990) 1.37
Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. Proc Natl Acad Sci U S A (1990) 1.36
Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder. Mol Cell Biol (1989) 1.34
An in vivo model of somatic cell gene therapy for human severe combined immunodeficiency. Science (1991) 1.19
Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells. Proc Natl Acad Sci U S A (1989) 0.99
Engraftment and development of human T and B cells in mice after bone marrow transplantation. Science (1991) 0.96
Expression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses. Proc Natl Acad Sci U S A (1990) 0.93
Use of scid mice to identify and quantitate lymphoid-restricted stem cells in long-term bone marrow cultures. Blood (1989) 0.91
Long-term expression of a T-cell receptor beta-chain gene in mice reconstituted with retrovirus-infected hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 0.88
Interleukin 6 dependence of spontaneous in vitro differentiation of B cells from patients with IgM gammapathy. Proc Natl Acad Sci U S A (1990) 0.88
A technique for detection and relative quantitative analysis of glucosephosphate isomerase isozymes from nanogram tissue samples. Biochem Genet (1978) 0.82
Major histocompatibility complex (MHC) restricted antigen recognition: high frequency of human T-cell clones recognizing novel MHC class II determinants. Hum Immunol (1987) 0.76
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell (1978) 7.53
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci U S A (1976) 5.81
ABFs, a family of ABA-responsive element binding factors. J Biol Chem (2000) 4.98
Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A (1998) 4.35
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med (2000) 4.18
Cloning of an immunoglobulin variable region gene from mouse embryo. Proc Natl Acad Sci U S A (1977) 3.21
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia (2012) 3.04
Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet (1999) 2.84
Intracisternal A-particle genes as movable elements in the mouse genome. Proc Natl Acad Sci U S A (1983) 2.76
Somatic changes in the content and context of immunoglobulin genes. Cold Spring Harb Symp Quant Biol (1977) 2.73
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38
Production of functional chimaeric mouse/human antibody. Nature (1985) 2.35
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
Diagnosis of nonpsychotic patients in community clinics. Am J Psychiatry (2000) 2.06
A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J Biol Chem (1997) 2.05
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc Natl Acad Sci U S A (1983) 2.03
Multiple coronary occlusions associated with ST-segment elevation. Clin Cardiol (1999) 2.02
Vascular patterning and leaf shape. Curr Opin Plant Biol (2001) 1.99
Interventions to reduce the burden of caregiving for an adult with dementia: a meta-analysis. Res Nurs Health (2001) 1.70
Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Mol Cell Biol (1998) 1.68
Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Curr Cancer Drug Targets (2010) 1.60
Secretion of a lambda 2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region. Cell (1983) 1.57
Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. Mol Cell Biol (1984) 1.55
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene. Proc Natl Acad Sci U S A (1981) 1.55
Treadmill training with body weight support: its effect on Parkinson's disease. Arch Phys Med Rehabil (2000) 1.53
COPD in Chinese nonsmokers. Eur Respir J (2009) 1.52
Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production. Nature (1983) 1.51
Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies. J Pediatr (1996) 1.50
Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J Neurosci (2000) 1.48
A custom-made nasal implant: prefabrication from curing of silicone adhesive. Plast Reconstr Surg (1996) 1.43
Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle. EMBO J (1988) 1.43
Wallerian degeneration of the pyramidal tract does not affect stroke rehabilitation outcome. Neurology (1998) 1.42
Identification of N-terminal residues on P-selectin glycoprotein ligand-1 required for binding to P-selectin. J Biol Chem (1998) 1.42
Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. Proc Natl Acad Sci U S A (1999) 1.42
Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40
Astrocytic gap junctions remain open during ischemic conditions. J Neurosci (1998) 1.39
Molecular cloning of an immunoglobulin kappa constant gene from NZB mouse. Gene (1981) 1.37
Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. Oncogene (2006) 1.35
Functional differences between immunoglobulins M and D expressed on the surface of an immature B-cell line. Proc Natl Acad Sci U S A (1988) 1.33
High level functional engraftment of severe combined immunodeficient mice with human peripheral blood lymphocytes following pretreatment with radiation and anti-asialo GM1. J Immunol Methods (1994) 1.32
Clinical features, investigation and treatment of post-traumatic syringomyelia. J Neurol Neurosurg Psychiatry (1981) 1.29
Haloperidol, lorazepam, or both for psychotic agitation? A multicenter, prospective, double-blind, emergency department study. Am J Emerg Med (1997) 1.27
Sequences within the spacer region of yeast rRNA cistrons that stimulate 35S rRNA synthesis in vivo mediate RNA polymerase I-dependent promoter and terminator activities. Mol Cell Biol (1989) 1.24
Rearrangement of the T-cell receptor beta-chain gene in non-T-cell, non-B-cell acute lymphoblastic leukemia of childhood. N Engl J Med (1985) 1.23
Dynamics of immunoglobulin genes. Immunol Rev (1977) 1.22
Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene (1993) 1.18
Killing of antigen-reactive B cells by class II-restricted, soluble antigen-specific CD8+ cytolytic T lymphocytes. Nature (1988) 1.18
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression. Oncogene (2010) 1.18
Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin gene of mouse. Nucleic Acids Res (1982) 1.17
The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology (2000) 1.17
A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior. Neuroscience (2005) 1.15
New use of a three-dimensional pellet culture system for human intervertebral disc cells: initial characterization and potential use for tissue engineering. Spine (Phila Pa 1976) (2001) 1.14
Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol (1994) 1.13
Linker-free directed assembly of high-performance integrated devices based on nanotubes and nanowires. Nat Nanotechnol (2006) 1.13
Treatment of fluoxetine-induced anorgasmia with amantadine. J Clin Psychiatry (1992) 1.11
Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility. Nature (1986) 1.11
Immunoglobulin mu-chain gene rearrangement in a patient with T cell acute lymphoblastic leukemia. J Clin Invest (1984) 1.10
Molecular cloning of POEM: a novel adhesion molecule that interacts with alpha8beta1 integrin. J Biol Chem (2001) 1.10
Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector. Proc Natl Acad Sci U S A (1985) 1.09
Cerebral protein synthesis in a genetic mouse model of phenylketonuria. Proc Natl Acad Sci U S A (2000) 1.09
Immunoglobulin gene rearrangement in acute myelogenous leukemia. Cancer Res (1984) 1.08
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res (1989) 1.07
Analysis of hybridoma mutants defective in synthesis of immunoglobulin M. Somat Cell Mol Genet (1986) 1.06
SpermCheck Fertility, an immunodiagnostic home test that detects normozoospermia and severe oligozoospermia. Hum Reprod (2010) 1.05
Mammalian ncRNA-disease repository: a global view of ncRNA-mediated disease network. Cell Death Dis (2013) 1.05
Quantitative determination of human cytomegalovirus target sequences in peripheral blood leukocytes by nested polymerase chain reaction and temperature gradient gel electrophoresis. J Gen Virol (1993) 1.04
Poly(U) polymerase in rat brain. Nature (1975) 1.04
Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. J Neurophysiol (2001) 1.04
Nucleotide sequences of immunoglobulin mu heavy chain deletion mutants. Nucleic Acids Res (1983) 1.03
The effects of calpeptin (a calpain specific inhibitor) on agonist induced microparticle formation from the platelet plasma membrane. Thromb Res (1993) 1.02
Antigen presentation by a B-cell line transfected with cloned immunoglobulin heavy- and light-chain genes specific for a defined hapten. Proc Natl Acad Sci U S A (1986) 1.02
Paired-pulse modulation at individual GABAergic synapses in rat hippocampus. J Physiol (2000) 1.02
The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion. Oncogene (2012) 1.00
A kainate receptor increases the efficacy of GABAergic synapses. Neuron (2001) 1.00
The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1. Curr Biol (1998) 0.99
Characterization of a mouse DNA clone containing an immunoglobulin variable region gene. Nucleic Acids Res (1978) 0.99
Idiopathic spinal cord herniation: report of three cases and review of the literature. Spine (Phila Pa 1976) (2000) 0.97
Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene. Mol Cell Biol (1988) 0.97
Effect of carbohydrate ingestion and hormonal responses on ratings of perceived exertion during prolonged cycling and running. Eur J Appl Physiol Occup Physiol (1999) 0.96
Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. J Virol (1997) 0.96
Amino acid residues in the T cell receptor CDR3 determine the antigenic reactivity patterns of insulin-reactive hybridomas. J Immunol (1991) 0.95
Coagulation and fibrinolysis disorder in muscular dystrophy. Muscle Nerve (2001) 0.95
Activation of complement by immunoglobulin M is impaired by the substitution serine-406----asparagine in the immunoglobulin mu heavy chain. Proc Natl Acad Sci U S A (1986) 0.95
Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells. Eur J Immunol (1996) 0.95
Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors. Org Lett (2001) 0.94
Molecular determinants of TCR expression and selection. Curr Opin Immunol (2001) 0.94
Longitudinal assessment of fibrinogen in relation to subclinical cardiovascular disease: the CARDIA study. J Thromb Haemost (2009) 0.94
Class I (H-2Kb) gene transfection reduces susceptibility of YAC-1 lymphoma targets to natural killer cells. Eur J Immunol (1990) 0.94
Endogenous interleukin 6 can function as an in vivo growth- stimulatory factor for advanced-stage human melanoma cells. Clin Cancer Res (1996) 0.93
Homozygous deletion of a DNA marker from chromosome 11p13 in sporadic Wilms tumor. Genomics (1988) 0.93
Complement activation by IgM: evidence for the importance of the third constant domain of the mu heavy chain. Eur J Immunol (1987) 0.92
Development and evaluation of high throughput functional assay methods for HERG potassium channel. J Biomol Screen (2001) 0.92
Thermostability of seven hepatitis C virus genotypes in vitro and in vivo. J Viral Hepat (2013) 0.92
A human model of xenogeneic graft-versus-host disease in SCID mice engrafted with human peripheral blood lymphocytes. Transplantation (1995) 0.91
Search for Z' --> e+ e- using dielectron mass and angular distribution. Phys Rev Lett (2006) 0.90
Generation and chracterization of variants of mouse hepatoma cells with defects in hepato-specific gene expression. I. Albumin synthesis variants. Somatic Cell Genet (1982) 0.90
Coupling of T-cell activation with T-cell receptor assembly. Year Immunol (1993) 0.90
Radioimmunoassay for antibodies to human skeletal muscle myosin in serum from patients with polymyositis. Clin Exp Immunol (1983) 0.90