Published in J Cell Biol on March 19, 2007
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Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nat Cell Biol (2010) 2.51
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Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15
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The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis. Mol Cell Biol (2007) 1.06
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A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. Mol Biol Cell (2010) 0.96
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Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proc Natl Acad Sci U S A (2012) 0.93
Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. J Immunol (2008) 0.87
Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell (2012) 0.85
Regulation of actin cytoskeleton by Rap1 binding to RacGEF1. Mol Cells (2012) 0.85
The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis, and the cortical localization of myosin II in Dictyostelium discoideum. Cell Motil Cytoskeleton (2009) 0.84
GxcC connects Rap and Rac signaling during Dictyostelium development. BMC Cell Biol (2013) 0.83
Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A. Mol Biol Cell (2008) 0.83
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How to understand and outwit adaptation. Dev Cell (2014) 0.82
A Coronin7 homolog with functions in actin-driven processes. J Biol Chem (2010) 0.81
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The small GTPases Ras and Rap1 bind to and control TORC2 activity. Sci Rep (2016) 0.76
Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1). Mol Cell Proteomics (2017) 0.75
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The I/LWEQ domain in RapGAP3 required for posterior localization in migrating cells. Mol Cells (2014) 0.75
Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proc Natl Acad Sci U S A (2017) 0.75
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Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo. Cell (1993) 2.61
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors. J Cell Biol (2004) 2.27
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Multiple myosin II heavy chain kinases: roles in filament assembly control and proper cytokinesis in Dictyostelium. Mol Biol Cell (2005) 1.48
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The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. J Biol Chem (2004) 1.37
Localization of two phosphorylation sites adjacent to a region important for polymerization on the tail of Dictyostelium myosin. EMBO J (1984) 1.31
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J Biol Chem (2000) 1.28
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J Biol Chem (2004) 1.26
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In vivo observations of myosin II dynamics support a role in rear retraction. Mol Biol Cell (1999) 1.05
Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. J Biol Chem (2004) 1.05
Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress. J Cell Sci (2002) 1.03
Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues. Immunology (2005) 0.98
Release of myosin II from the membrane-cytoskeleton of Dictyostelium discoideum mediated by heavy-chain phosphorylation at the foci within the cortical actin network. J Cell Biol (1992) 0.97
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Transduction of the chemotactic signal to the actin cytoskeleton of Dictyostelium discoideum. Dev Biol (1989) 0.94
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Identification of a myosin VII-talin complex. J Biol Chem (2005) 0.92
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Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly. J Biol Chem (2004) 0.92
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Mutational analysis of the role of Rap1 in regulating cytoskeletal function in Dictyostelium. Exp Cell Res (1997) 0.91
Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton. Mol Biol Cell (2003) 0.90
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Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway. Mol Cell Biol (2002) 0.87
A novel phosphatidylinositol 4,5-bisphosphate-binding domain targeting the Phg2 kinase to the membrane in Dictyostelium cells. Eur J Cell Biol (2005) 0.86
Cell migration: integrating signals from front to back. Science (2003) 29.13
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production. Plant Cell (2002) 5.81
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci (2003) 2.49
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CZH proteins: a new family of Rho-GEFs. J Cell Sci (2005) 2.29
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry. Proc Natl Acad Sci U S A (2007) 2.11
Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev (2006) 1.95
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
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A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell (2010) 1.74
Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature (2009) 1.71
Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep (2004) 1.63
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal (2012) 1.53
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol (2006) 1.51
Insights into morphogenesis from a simple developmental system. Nat Rev Mol Cell Biol (2004) 1.48
A hypermorphic mutation in the protein phosphatase 2C HAB1 strongly affects ABA signaling in Arabidopsis. FEBS Lett (2006) 1.48
Myosin II is essential for the spatiotemporal organization of traction forces during cell motility. Mol Biol Cell (2009) 1.37
Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. J Biol Chem (2002) 1.36
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol Biol Cell (2006) 1.36
Activated membrane patches guide chemotactic cell motility. PLoS Comput Biol (2011) 1.32
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J Biol Chem (2007) 1.30
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A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell (2005) 1.24
A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates. Plant J (2008) 1.17
The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover. PLoS One (2010) 1.16
Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response. Curr Opin Genet Dev (2004) 1.15
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum. J Biol Chem (2006) 1.14
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell (2010) 1.13
Two poles and a compass. Cell (2003) 1.10
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase. Development (2008) 1.04
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol (2007) 1.04
Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci (2013) 1.03
Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress. J Cell Sci (2002) 1.03
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. EMBO Rep (2007) 1.01
Rho Rocks PTEN. Nat Cell Biol (2005) 1.01
Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol (2014) 0.99
Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis. Exp Cell Res (2005) 0.97
RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum. Eukaryot Cell (2004) 0.97
A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. Mol Biol Cell (2010) 0.96
Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation. J Biol Chem (2008) 0.95
Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium. J Cell Sci (2009) 0.95
Cytoskeletal regulation by Dictyostelium Ras subfamily proteins. J Muscle Res Cell Motil (2002) 0.95
Phospho-site mapping, genetic and in planta activation studies reveal key aspects of the different phosphorylation mechanisms involved in activation of SnRK2s. Plant J (2010) 0.95
Signaling pathways at the leading edge of chemotaxing cells. J Muscle Res Cell Motil (2002) 0.95
A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium. Mol Biol Cell (2003) 0.93
Regulation of Dictyostelium morphogenesis by RapGAP3. Dev Biol (2009) 0.92
A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem (2003) 0.92
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mol Cell Biol (2005) 0.91
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell (2008) 0.90
Regulation of contractile vacuole formation and activity in Dictyostelium. EMBO J (2008) 0.90
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MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis. Mol Cell Biol (2007) 0.90
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Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell (2012) 0.85
The cdk5 homologue, crp, regulates endocytosis and secretion in dictyostelium and is necessary for optimum growth and differentiation. Dev Biol (2002) 0.84
The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Mol Biol Cell (2011) 0.83
A homologue of Cdk8 is required for spore cell differentiation in Dictyostelium. Dev Biol (2004) 0.83
Developmental lineage priming in Dictyostelium by heterogeneous Ras activation. Elife (2013) 0.81
An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1. Microbiology (2006) 0.80
The metal hyperaccumulators from New Caledonia can broaden our understanding of nickel accumulation in plants. Front Plant Sci (2013) 0.80
Regulation of a LATS-homolog by Ras GTPases is important for the control of cell division. BMC Cell Biol (2014) 0.79
An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells. Cell Mol Bioeng (2011) 0.79
RasG signaling is important for optimal folate chemotaxis in Dictyostelium. BMC Cell Biol (2014) 0.79
A novel Dictyostelium RasGEF required for chemotaxis and development. BMC Cell Biol (2005) 0.79
The effect of the disruption of a gene encoding a PI4 kinase on the developmental defect exhibited by Dictyostelium rasC(-) cells. Dev Biol (2005) 0.78
Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis. J Biol Chem (2013) 0.78
Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Found Symp (2005) 0.78
Determinants of RasC specificity during Dictyostelium aggregation. J Biol Chem (2010) 0.78
Assaying chemotaxis of Dictyostelium cells. Methods Mol Biol (2006) 0.78
Leading the way. Nat Cell Biol (2002) 0.76
"TORCing" neutrophil chemotaxis. Dev Cell (2010) 0.76
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A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures. Dev Biol (2006) 0.75
The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development. Dev Biol (2003) 0.75