Published in Curr Biol on October 28, 2008
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A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility. PLoS Biol (2010) 1.90
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An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol (2013) 1.34
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Activated membrane patches guide chemotactic cell motility. PLoS Comput Biol (2011) 1.32
Biased excitable networks: how cells direct motion in response to gradients. Curr Opin Cell Biol (2011) 1.24
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Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell (2010) 1.13
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLoS Comput Biol (2013) 1.10
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Analysis of chemotaxis in Dictyostelium. Methods Mol Biol (2012) 0.96
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A dynamic response regulator protein modulates G-protein-dependent polarity in the bacterium Myxococcus xanthus. PLoS Genet (2012) 0.93
Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A (2013) 0.92
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Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell (2012) 0.85
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The local cell curvature guides pseudopodia towards chemoattractants. HFSP J (2009) 0.84
Genetic control of morphogenesis in Dictyostelium. Dev Biol (2015) 0.84
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How to understand and outwit adaptation. Dev Cell (2014) 0.82
RasG signaling is important for optimal folate chemotaxis in Dictyostelium. BMC Cell Biol (2014) 0.79
A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration. Sci Rep (2016) 0.78
Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum. J Biomed Sci (2012) 0.78
Three-dimensional numerical model of cell morphology during migration in multi-signaling substrates. PLoS One (2015) 0.78
Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium. Mol Biol Cell (2013) 0.77
The small GTPases Ras and Rap1 bind to and control TORC2 activity. Sci Rep (2016) 0.76
The novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cells. Mol Biol Cell (2016) 0.76
A Model for Direction Sensing in Dictyostelium discoideum: Ras Activity and Symmetry Breaking Driven by a Gβγ-Mediated, Gα2-Ric8 -- Dependent Signal Transduction Network. PLoS Comput Biol (2016) 0.75
Adaptation in a eukaryotic pathway: combining experiments with modeling. Cell Cycle (2012) 0.75
A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol (2017) 0.75
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G protein signaling events are activated at the leading edge of chemotactic cells. Cell (1998) 6.60
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Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell (2002) 6.06
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Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06
Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol (2001) 3.03
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
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Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev (2006) 1.95
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Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol (2006) 1.76
Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell (2005) 1.73
A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells. Cell Motil Cytoskeleton (1998) 1.66
Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep (2004) 1.63
Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium. Curr Biol (2001) 1.54
Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol (2007) 1.45
RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation. EMBO J (2001) 1.44
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol Biol Cell (2006) 1.36
A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle. Cell Motil Cytoskeleton (2003) 1.34
A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol (2007) 1.32
Neurofibromin: a general outlook. Clin Genet (2006) 1.31
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J Biol Chem (2007) 1.30
Chemotaxis: navigating by multiple signaling pathways. Sci STKE (2007) 1.15
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Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. J Cell Biol (2008) 0.98
RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum. Eukaryot Cell (2004) 0.97
Molecular and functional analysis of the dictyostelium centrosome. Int Rev Cytol (2004) 0.95