Published in PLoS Genet on March 23, 2007
Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genet Epidemiol (2009) 2.19
Inferring combined CNV/SNP haplotypes from genotype data. Bioinformatics (2010) 1.35
hapConstructor: automatic construction and testing of haplotypes in a Monte Carlo framework. Bioinformatics (2008) 1.17
Bayesian quantitative trait locus mapping using inferred haplotypes. Genetics (2010) 1.05
Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions. BMC Bioinformatics (2008) 1.01
Estrogen-related genes and their contribution to racial differences in breast cancer risk. Cancer Causes Control (2012) 0.89
A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies. Hum Hered (2011) 0.89
Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis. BMC Genet (2008) 0.85
Automated construction and testing of multi-locus gene-gene associations. Bioinformatics (2010) 0.84
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The International HapMap Project. Nature (2003) 73.65
Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics (2002) 34.50
A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet (2003) 26.59
Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet (2001) 22.07
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet (2001) 10.48
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A (2000) 10.27
Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet (1995) 8.09
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet (1998) 7.56
Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat Genet (2004) 5.78
Evaluating associations of haplotypes with traits. Genet Epidemiol (2004) 5.70
Haplotypes vs single marker linkage disequilibrium tests: what do we gain? Eur J Hum Genet (2001) 5.41
A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet (2001) 5.06
The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. Genome Res (1999) 5.03
On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals. Genet Epidemiol (2003) 4.67
Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes. Am J Hum Genet (2004) 4.44
Bayesian analysis of haplotypes for linkage disequilibrium mapping. Genome Res (2001) 3.49
Analysis of single-locus tests to detect gene/disease associations. Genet Epidemiol (2005) 3.27
Lactase haplotype diversity in the Old World. Am J Hum Genet (2000) 3.19
On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit. Am J Hum Genet (2003) 3.16
Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes. Am J Hum Genet (2003) 2.94
Haplotype block structure and its applications to association studies: power and study designs. Am J Hum Genet (2002) 2.88
A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies. Am J Hum Genet (2003) 2.88
The relative power of SNPs and haplotype as genetic markers for association tests. Pharmacogenomics (2001) 2.83
Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies. Am J Hum Genet (2002) 2.72
Fine-scale mapping of disease genes with multiple mutations via spatial clustering techniques. Am J Hum Genet (2003) 2.57
HaploBlockFinder: haplotype block analyses. Bioinformatics (2003) 2.47
Genetic association studies: design, analysis and interpretation. Brief Bioinform (2002) 2.35
Haplotype analysis in population genetics and association studies. Pharmacogenomics (2003) 2.13
Linkage disequilibrium and association of MAPT H1 in Parkinson disease. Am J Hum Genet (2004) 2.10
Transmission/disequilibrium test based on haplotype sharing for tightly linked markers. Am J Hum Genet (2003) 1.84
Evolutionary-based association analysis using haplotype data. Genet Epidemiol (2003) 1.73
Regression-based association analysis with clustered haplotypes through use of genotypes. Am J Hum Genet (2005) 1.71
Evolutionary-based grouping of haplotypes in association analysis. Genet Epidemiol (2005) 1.67
Search for multifactorial disease susceptibility genes in founder populations. Ann Hum Genet (2000) 1.66
Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes. Am J Hum Genet (2001) 1.62
Bayesian spatial modeling of haplotype associations. Hum Hered (2003) 1.59
Genome scan of complex traits by haplotype sharing correlation. Genet Epidemiol (2001) 1.39
Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity. Proc Natl Acad Sci U S A (2003) 1.33
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. BMC Genet (2006) 1.33
Use of closely related affected individuals for the genetic study of complex diseases in founder populations. Am J Hum Genet (2000) 1.23
Haplotype information and linkage disequilibrium mapping for single nucleotide polymorphisms. Genome Res (2003) 1.21
Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping. Genet Epidemiol (2004) 1.17
Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies. Ann Hum Genet (2005) 1.15
Tests of association between quantitative traits and haplotypes in a reduced-dimensional space. Ann Hum Genet (2005) 1.09
Fine mapping functional sites or regions from case-control data using haplotypes of multiple linked SNPs. Ann Hum Genet (2005) 1.01
htSNPer1.0: software for haplotype block partition and htSNPs selection. BMC Bioinformatics (2005) 0.99
Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers. Genetics (2003) 0.97
Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes (2004) 0.96
Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. J Hum Genet (2005) 0.91
Missing data in haplotype analysis: a study on the MILC method. Ann Hum Genet (2002) 0.89
Haplotype-sharing analysis using Mantel statistics for combined genetic effects. BMC Genet (2005) 0.86
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. Tissue Antigens (2005) 0.83
Analyses and comparison of accuracy of different genotype imputation methods. PLoS One (2008) 3.41
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet (2008) 3.24
Relationship of obesity with osteoporosis. J Clin Endocrinol Metab (2007) 2.71
Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am J Hum Genet (2008) 2.65
Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res (2008) 2.40
Meta-analysis suggests that smoking is associated with an increased risk of early natural menopause. Menopause (2012) 2.36
Genome partitioning of genetic variation for height from 11,214 sibling pairs. Am J Hum Genet (2007) 2.27
Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genet Epidemiol (2009) 2.19
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet (2009) 2.14
Hotelling's T2 multivariate profiling for detecting differential expression in microarrays. Bioinformatics (2005) 2.10
Comparative studies of de novo assembly tools for next-generation sequencing technologies. Bioinformatics (2011) 2.05
Mutation patterns at dinucleotide microsatellite loci in humans. Am J Hum Genet (2002) 1.71
Rare ADH variant constellations are specific for alcohol dependence. Alcohol Alcohol (2012) 1.66
Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J Bone Miner Res (2006) 1.52
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology (2011) 1.50
Comparative studies of copy number variation detection methods for next-generation sequencing technologies. PLoS One (2013) 1.48
Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol (2003) 1.48
Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density. J Bone Miner Res (2013) 1.45
SNP rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans. J Bone Miner Res (2013) 1.44
Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet (2010) 1.41
Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population. J Hum Genet (2009) 1.40
Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. Hum Genet (2008) 1.39
Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone (2012) 1.38
Bayesian mapping of quantitative trait loci for multiple complex traits with the use of variance components. Am J Hum Genet (2007) 1.35
Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring) (2007) 1.32
SNPP: automating large-scale SNP genotype data management. Bioinformatics (2004) 1.31
A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. J Biol Chem (2005) 1.30
Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. Am J Hum Genet (2009) 1.28
Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. PLoS One (2009) 1.26
Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res (2006) 1.24
Genome-wide association study of exercise behavior in Dutch and American adults. Med Sci Sports Exerc (2009) 1.22
Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. PLoS Genet (2009) 1.21
Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. PLoS One (2008) 1.21
A new permutation strategy of pathway-based approach for genome-wide association study. BMC Bioinformatics (2009) 1.19
On genome-wide association studies and their meta-analyses: lessons learned from osteoporosis studies. J Clin Endocrinol Metab (2013) 1.18
Is replication the gold standard for validating genome-wide association findings? PLoS One (2008) 1.18
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet (2013) 1.17
Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis. J Bone Miner Res (2005) 1.16
Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche. J Clin Endocrinol Metab (2006) 1.16
Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. J Bone Miner Res (2010) 1.15
Analyses and comparison of imputation-based association methods. PLoS One (2010) 1.12
Genome-wide association study identified UQCC locus for spine bone size in humans. Bone (2012) 1.12
Group sparse canonical correlation analysis for genomic data integration. BMC Bioinformatics (2013) 1.12
Comparison of population-based association study methods correcting for population stratification. PLoS One (2008) 1.11
Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity. Obesity (Silver Spring) (2010) 1.10
Univariate/multivariate genome-wide association scans using data from families and unrelated samples. PLoS One (2009) 1.10
Genetic linkage of human height is confirmed to 9q22 and Xq24. Hum Genet (2006) 1.10
Role of genetics in osteoporosis. Endocrine (2002) 1.10
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. Am J Med Genet B Neuropsychiatr Genet (2013) 1.08
Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity. Osteoporos Int (2005) 1.08
Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effects. J Bone Miner Res (2006) 1.08
Gene selection for classification of microarray data based on the Bayes error. BMC Bioinformatics (2007) 1.07
Whole genome distribution and ethnic differentiation of copy number variation in Caucasian and Asian populations. PLoS One (2009) 1.06
Searching for osteoporosis genes in the post-genome era: progress and challenges. Osteoporos Int (2003) 1.05
Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Hum Mol Genet (2008) 1.03
Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear families. Osteoporos Int (2005) 1.03
Receiver-operating characteristic analyses of body mass index, waist circumference and waist-to-hip ratio for obesity: Screening in young adults in central south of China. Clin Nutr (2006) 1.02
Efficient utilization of rare variants for detection of disease-related genomic regions. PLoS One (2010) 1.02
The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring) (2009) 1.02
Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females. Hum Mol Genet (2006) 1.01
Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. Ann Hum Genet (2009) 1.01
In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. J Bone Miner Res (2008) 1.00
Polymorphisms in predicted miRNA binding sites and osteoporosis. J Bone Miner Res (2011) 1.00
Genetic dissection of human stature in a large sample of multiplex pedigrees. Ann Hum Genet (2004) 1.00
Runs of homozygosity identify a recessive locus 12q21.31 for human adult height. J Clin Endocrinol Metab (2010) 1.00
Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Endocr Rev (2010) 1.00
Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans. Mol Cell Proteomics (2011) 0.99
Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences. BMC Bioinformatics (2014) 0.99
Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts. PLoS One (2011) 0.98
Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females. Hum Reprod (2007) 0.98
Genome-wide association study of copy number variation identified gremlin1 as a candidate gene for lean body mass. J Hum Genet (2011) 0.97
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. Am J Med Genet B Neuropsychiatr Genet (2012) 0.97
Molecular genetic studies of gene identification for sarcopenia. Hum Genet (2011) 0.97
Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. Genomics (2009) 0.96
Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics (2005) 0.96
Genetic association study of common mitochondrial variants on body fat mass. PLoS One (2011) 0.96
Classification of multicolor fluorescence in situ hybridization (M-FISH) images with sparse representation. IEEE Trans Nanobioscience (2012) 0.96
Genetics of bone mineral density: evidence for a major pleiotropic effect from an intercontinental study. J Bone Miner Res (2004) 0.96
Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. Calcif Tissue Int (2009) 0.95
Nonreplication in genetic studies of complex diseases--lessons learned from studies of osteoporosis and tentative remedies. J Bone Miner Res (2004) 0.95
Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. J Genet (2007) 0.95
Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites. J Bone Miner Res (2007) 0.95
Race and sex differences and contribution of height: a study on bone size in healthy Caucasians and Chinese. Am J Hum Biol (2005) 0.94
Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. Proteomics (2008) 0.94
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. Alcohol Clin Exp Res (2012) 0.94
Involvement of the skeletal renin-angiotensin system in age-related osteoporosis of ageing mice. Biosci Biotechnol Biochem (2012) 0.94
Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians. Eur J Hum Genet (2008) 0.93
A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. J Clin Endocrinol Metab (2007) 0.93
A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure. J Bone Miner Res (2008) 0.93
Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis. BMC Genet (2004) 0.93
Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. Hum Mol Genet (2013) 0.93
Evaluation of compressive strength index of the femoral neck in Caucasians and chinese. Calcif Tissue Int (2010) 0.92
IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. J Bone Miner Res (2010) 0.92
Mapping quantitative trait loci for cross-sectional geometry at the femoral neck. J Bone Miner Res (2005) 0.92
Association and haplotype analyses of the COL1A2 and ER-alpha gene polymorphisms with bone size and height in Chinese. Bone (2005) 0.92
Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity. J Bone Miner Metab (2003) 0.91
Improved detection of rare genetic variants for diseases. PLoS One (2010) 0.91
A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. Hum Genet (2006) 0.91
Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass. J Bone Miner Res (2007) 0.91