Published in Nat Protoc on January 01, 2006
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. Cell Host Microbe (2010) 3.27
the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog (2008) 1.94
Candida infections of the genitourinary tract. Clin Microbiol Rev (2010) 1.90
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest (2007) 1.67
From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLoS One (2011) 1.54
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology (2008) 1.52
Animal models of mucosal Candida infection. FEMS Microbiol Lett (2008) 1.33
Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells. PLoS One (2011) 1.15
Candida albicans versus Candida dubliniensis: Why Is C. albicans More Pathogenic? Int J Microbiol (2011) 1.08
Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model. Eukaryot Cell (2009) 1.05
The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLoS One (2011) 1.00
Real-time PCR expression profiling of genes encoding potential virulence factors in Candida albicans biofilms: identification of model-dependent and -independent gene expression. BMC Microbiol (2010) 0.99
Epithelial cells and innate antifungal defense. J Dent Res (2010) 0.99
Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling. J Infect Dis (2013) 0.98
Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions. PLoS One (2012) 0.95
Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans. J Biomed Sci (2012) 0.94
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (2014) 0.94
Candida albicans cell wall glycosylation may be indirectly required for activation of epithelial cell proinflammatory responses. Infect Immun (2011) 0.93
Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae. Med Microbiol Immunol (2011) 0.92
The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol (2009) 0.89
Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans. BMC Microbiol (2008) 0.85
Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis. Virulence (2014) 0.81
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans. Nat Commun (2016) 0.80
Oral and vaginal epithelial cell lines bind and transfer cell-free infectious HIV-1 to permissive cells but are not productively infected. PLoS One (2014) 0.80
Modeling mucosal candidiasis in larval zebrafish by swimbladder injection. J Vis Exp (2014) 0.79
Prediction of phenotype-associated genes via a cellular network approach: a Candida albicans infection case study. PLoS One (2012) 0.78
Dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses. Infect Immun (2015) 0.77
New "haploid biofilm model" unravels IRA2 as a novel regulator of Candida albicans biofilm formation. Sci Rep (2015) 0.76
Novel Nystatin A₁ derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Med Microbiol Immunol (2014) 0.76
Cytotoxicity and Antimicrobial Activity of Oral Rinses In Vitro. Biomed Res Int (2017) 0.75
Experimental Models of Vaginal Candidiasis and Their Relevance to Human Candidiasis. Infect Immun (2016) 0.75
Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet (1984) 11.51
ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiology (2004) 2.62
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion. Infect Immun (2002) 1.91
Analysis of the Candida albicans Als2p and Als4p adhesins suggests the potential for compensatory function within the Als family. Microbiology (2005) 1.85
RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms. Microbiology (2004) 1.79
Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem (2005) 1.77
Rational design and in vitro and in vivo delivery of Dicer substrate siRNA. Nat Protoc (2006) 1.74
Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol Microbiol (1998) 1.70
Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol (1999) 1.69
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium. Infect Immun (2003) 1.49
In vitro reconstructed human epithelia reveal contributions of Candida albicans EFG1 and CPH1 to adhesion and invasion. Microbiology (2002) 1.42
Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection. J Leukoc Biol (2001) 1.30
Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence. J Invest Dermatol (2002) 1.27
Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat? Microbes Infect (2003) 1.27
Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis. Microbiology (2004) 1.23
Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases. Infect Immun (2005) 1.15
Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infect Immun (2005) 1.11
Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium. J Med Microbiol (2003) 1.11
Development of a novel three-dimensional in vitro model of oral Candida infection. Microb Pathog (2006) 1.07
Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients. Antimicrob Agents Chemother (1999) 1.05
Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis. Infect Immun (2002) 0.98
Host defense effector molecules in mucosal secretions. FEMS Immunol Med Microbiol (2005) 0.90
Reverse transcription - 3' rapid amplification of cDNA ends-nested PCR of ACT1 and SAP2 mRNA as a means of detecting viable Candida albicans in an in vitro cutaneous candidiasis model. J Invest Dermatol (2000) 0.90
Cytokine expression induced by Candida albicans in a model of cutaneous candidosis based on reconstituted human epidermis. J Med Microbiol (2002) 0.84
Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature (2009) 5.90
Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev (2003) 4.07
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. Cell Host Microbe (2010) 3.27
Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol (2005) 3.00
Candida albicans pathogenicity mechanisms. Virulence (2013) 2.60
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol (2007) 2.35
Stage-specific gene expression of Candida albicans in human blood. Mol Microbiol (2003) 1.97
Hydrolytic enzymes as virulence factors of Candida albicans. Mycoses (2005) 1.96
the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog (2008) 1.94
Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Infect Immun (2002) 1.82
Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol (2009) 1.77
Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem (2005) 1.77
Candida albicans proteinases and host/pathogen interactions. Cell Microbiol (2004) 1.73
Anti-fungal therapy at the HAART of viral therapy. Trends Microbiol (2002) 1.72
In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. Mol Microbiol (2007) 1.68
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest (2007) 1.67
From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLoS One (2011) 1.54
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology (2008) 1.52
A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites. Mol Microbiol (2002) 1.52
Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol (2012) 1.50
Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs. Eur J Immunol (2012) 1.50
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium. Infect Immun (2003) 1.49
A role for the EAL-like protein STM1344 in regulation of CsgD expression and motility in Salmonella enterica serovar Typhimurium. J Bacteriol (2009) 1.41
Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape. Curr Opin Microbiol (2010) 1.39
An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Front Microbiol (2012) 1.35
Candida albicans iron acquisition within the host. FEMS Yeast Res (2009) 1.35
Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther (2012) 1.34
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol (2011) 1.34
Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog (2012) 1.34
The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol (2011) 1.33
Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol (2004) 1.29
Comparative genomics using Candida albicans DNA microarrays reveals absence and divergence of virulence-associated genes in Candida dubliniensis. Microbiology (2004) 1.29
Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence. J Invest Dermatol (2002) 1.27
Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis. Microbiology (2004) 1.23
Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin. Immunity (2007) 1.21
Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids. Clin Vaccine Immunol (2006) 1.21
Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity (2005) 1.21
Expression analysis of the Candida albicans lipase gene family during experimental infections and in patient samples. FEMS Yeast Res (2004) 1.20
Bistable expression of CsgD in biofilm development of Salmonella enterica serovar typhimurium. J Bacteriol (2009) 1.19
Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cell Microbiol (2013) 1.19
Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res (2009) 1.19
A novel immune evasion strategy of candida albicans: proteolytic cleavage of a salivary antimicrobial peptide. PLoS One (2009) 1.18
Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect (2011) 1.17
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging (2006) 1.17
The fibrinogen receptor FbsA promotes adherence of Streptococcus agalactiae to human epithelial cells. Infect Immun (2004) 1.16
Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells. PLoS One (2011) 1.15
Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions. Microbes Infect (2007) 1.15
Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLoS One (2012) 1.15
Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. J Antimicrob Chemother (2005) 1.13
Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol (2007) 1.13
Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLoS One (2012) 1.12
Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infect Immun (2005) 1.11
Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium. J Med Microbiol (2003) 1.11
Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages. PLoS One (2012) 1.08
Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. PLoS One (2012) 1.06
Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother (2003) 1.06
The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol (2009) 1.06
Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell (2010) 1.03
Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells. BMC Syst Biol (2010) 1.02
Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol (2013) 1.02
Mucosal immunity and Candida albicans infection. Clin Dev Immunol (2011) 1.01
The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLoS One (2011) 1.00
Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. J Infect Dis (2013) 1.00
A core filamentation response network in Candida albicans is restricted to eight genes. PLoS One (2013) 0.99
The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity. Infect Immun (2010) 0.98
Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling. J Infect Dis (2013) 0.98
Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. Eur J Immunol (2013) 0.98
Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence. Infect Immun (2010) 0.97
MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur. Microbiology (2006) 0.96
Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions. PLoS One (2012) 0.95
The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils. Infect Immun (2009) 0.95
The novel Candida albicans transporter Dur31 Is a multi-stage pathogenicity factor. PLoS Pathog (2012) 0.95
Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris. BMC Microbiol (2008) 0.94
Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol (2011) 0.94
Fungal adaptation to the host environment. Curr Opin Microbiol (2009) 0.94
Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface. Virulence (2015) 0.94
Candida albicans cell wall glycosylation may be indirectly required for activation of epithelial cell proinflammatory responses. Infect Immun (2011) 0.93
The role of secreted aspartyl proteinases in Candida albicans keratitis. Invest Ophthalmol Vis Sci (2007) 0.93
Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One (2012) 0.93
Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae. Med Microbiol Immunol (2011) 0.92
Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection. Med Mycol (2009) 0.92
Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation. Eukaryot Cell (2009) 0.91
Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell (2013) 0.90
Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother (2011) 0.90
Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans. Microbiology (2005) 0.89
The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence. Yeast (2010) 0.89
The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications. Infect Immun (2006) 0.89
Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections. PLoS One (2011) 0.88
3D-wound healing model: influence of morphine and solid lipid nanoparticles. J Biotechnol (2010) 0.88
Zinc exploitation by pathogenic fungi. PLoS Pathog (2012) 0.88
The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem (2011) 0.87
Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother (2005) 0.86