Published in Nat Biotechnol on October 01, 2010
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet (2010) 7.39
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
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Linking cell signaling and the epigenetic machinery. Nat Biotechnol (2010) 1.03
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High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
International network of cancer genome projects. Nature (2010) 20.35
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DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
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The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
ChIP-seq: advantages and challenges of a maturing technology. Nat Rev Genet (2009) 13.12
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods (2009) 10.17
Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat Biotechnol (2010) 9.84
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
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Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Epigenetics in cancer. Carcinogenesis (2009) 7.49
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Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci (2007) 6.00
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Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
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A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40
Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nat Methods (2010) 4.30
An operational definition of epigenetics. Genes Dev (2009) 4.26
Reaction of bisulfite with the 5-hydroxymethyl group in pyrimidines and in phage DNAs. Biochemistry (1979) 3.91
Purification of proteins associated with specific genomic Loci. Cell (2009) 3.53
Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations. Nat Genet (2006) 3.44
A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop. Cancer Res (2005) 3.35
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Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet (2008) 3.16
Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02
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Moving AHEAD with an international human epigenome project. Nature (2008) 2.38
Multiplex padlock targeted sequencing reveals human hypermutable CpG variations. Genome Res (2009) 2.38
Chromatin poises miRNA- and protein-coding genes for expression. Genome Res (2009) 2.28
Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nat Methods (2009) 2.26
Epigenetics and the environmental regulation of the genome and its function. Annu Rev Psychol (2010) 2.16
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Epigenetic changes in cancer. APMIS (2007) 1.96
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Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions. Genome Res (2009) 1.52
Emerging similarities in epigenetic gene silencing by long noncoding RNAs. Mamm Genome (2009) 1.20
Epigenetic cancer therapy makes headway. J Natl Cancer Inst (2006) 1.18
Targeted therapy for inherited GPI deficiency. N Engl J Med (2007) 1.17
Hunting for the 5th base: Techniques for analyzing DNA methylation. Biochim Biophys Acta (2009) 1.03
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
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DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell (2008) 7.68
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biol (2008) 4.50
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57
Genomic patterns of DNA methylation: targets and function of an epigenetic mark. Curr Opin Cell Biol (2007) 3.54
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Determinants and dynamics of genome accessibility. Nat Rev Genet (2011) 3.15
A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol (2003) 3.09
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07
Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell (2009) 3.02
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol (2008) 2.85
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J (2008) 2.81
DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. Proc Natl Acad Sci U S A (2004) 2.66
Genetics and epigenetics: stability and plasticity during cellular differentiation. Trends Genet (2009) 2.57
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells (2007) 2.40
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell (2008) 2.28
Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev (2005) 2.26
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J (2007) 2.19
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18
Methylated DNA immunoprecipitation (MeDIP). Methods Mol Biol (2009) 2.17
Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. Genes Dev (2009) 2.08
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell (2013) 2.06
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell (2007) 2.05
A question of timing: emerging links between transcription and replication. Curr Opin Genet Dev (2006) 2.00
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood (2008) 1.97
Genomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells. PLoS Genet (2011) 1.97
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell (2013) 1.85
Methylation-dependent and -independent genomic targeting principles of the MBD protein family. Cell (2013) 1.79
Zic3 is required for maintenance of pluripotency in embryonic stem cells. Mol Biol Cell (2007) 1.77
p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem (2004) 1.70
Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa. Genome Res (2008) 1.61
Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Nat Struct Mol Biol (2010) 1.57
DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation. Mol Cell Biol (2002) 1.57
Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa. Nat Struct Mol Biol (2013) 1.54
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ChIPs of the beta-globin locus: unraveling gene regulation within an active domain. Curr Opin Genet Dev (2002) 1.45
In vivo epigenomic profiling of germ cells reveals germ cell molecular signatures. Dev Cell (2013) 1.43
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Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell (2013) 1.42
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KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells (2009) 1.39
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev (2012) 1.34
A chromatin-modifying function of JNK during stem cell differentiation. Nat Genet (2011) 1.31
DNA methylation is required for the control of stem cell differentiation in the small intestine. Genes Dev (2014) 1.31
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Zfp143 regulates Nanog through modulation of Oct4 binding. Stem Cells (2008) 1.27
Identification of active regulatory regions from DNA methylation data. Nucleic Acids Res (2013) 1.26
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
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Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome. Genome Res (2010) 1.12
Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels. Mol Syst Biol (2012) 1.10
Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome. Genome Biol (2012) 1.09
H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming. Nat Struct Mol Biol (2009) 1.08
Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells. Mol Cell (2013) 1.03
BLIMP1 regulates cell growth through repression of p53 transcription. Proc Natl Acad Sci U S A (2007) 1.03
Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state. Proc Natl Acad Sci U S A (2012) 1.02
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A fluorescent rosamine compound selectively stains pluripotent stem cells. Angew Chem Int Ed Engl (2010) 1.01
Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice. PLoS One (2011) 1.00
Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation. PLoS One (2013) 0.99
Ezh2 is required for neural crest-derived cartilage and bone formation. Development (2014) 0.97
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LincRNAs join the pluripotency alliance. Nat Genet (2010) 0.81
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Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure. Stem Cells (2014) 0.79
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