Chemokines and their receptors as potential targets for the treatment of asthma.

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Published in Br J Pharmacol on April 30, 2007

Authors

C Palmqvist1, A J Wardlaw, P Bradding

Author Affiliations

1: Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK.

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Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 4.75

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Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med (2000) 4.29

Eosinophilia. N Engl J Med (1998) 4.14

Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med (1999) 3.84

Interleukin-5, eosinophils, and disease. Blood (1992) 3.80

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol (2001) 3.76

Subepithelial fibrosis in the bronchi of asthmatics. Lancet (1989) 3.70

Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis (1988) 3.45

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol (2000) 3.44

Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med (2003) 3.34

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med (1996) 3.33

Non-eosinophilic corticosteroid unresponsive asthma. Lancet (1999) 3.25

Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest (2001) 3.19

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc Natl Acad Sci U S A (1999) 3.00

Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol (2003) 2.95

Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med (2004) 2.93

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol (1992) 2.89

Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol (1995) 2.88

Rules of chemokine receptor association with T cell polarization in vivo. J Clin Invest (2001) 2.87

Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis (1993) 2.83

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol (1994) 2.73

Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis (1993) 2.69

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax (2002) 2.63

The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol (2006) 2.35

Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med (2001) 2.34

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The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A (2002) 2.24

Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14

Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med (2000) 2.06

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CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J Exp Med (2002) 2.00

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Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood (2002) 1.91

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J Immunol (1990) 1.88

Severe asthma in adults. Am J Respir Crit Care Med (2005) 1.74

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest (2002) 1.73

Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol (1997) 1.69

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Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol (1996) 1.66

Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol (2001) 1.65

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Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol (1991) 1.60

Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. J Clin Invest (1991) 1.60

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Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma. Am Rev Respir Dis (1988) 1.52

Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. Br Med J (Clin Res Ed) (1985) 1.49

Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J Immunol (1998) 1.45

Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci U S A (2005) 1.43

Functional KCa3.1 K+ channels are required for human lung mast cell migration. Thorax (2006) 1.39

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Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Intern Med (1997) 1.13

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The inflammation-repair cycle in asthma: the pivotal role of the airway epithelium. Clin Exp Allergy (1998) 1.08

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