Published in J Mol Biol on May 03, 2007
Functions of S100 proteins. Curr Mol Med (2013) 2.43
Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity (2013) 1.77
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proc Natl Acad Sci U S A (2013) 1.64
Structural and functional insights into RAGE activation by multimeric S100B. EMBO J (2007) 1.59
Human calprotectin is an iron-sequestering host-defense protein. Nat Chem Biol (2015) 1.57
ANTI-INFECTIVE PROTECTIVE PROPERTIES OF S100 CALGRANULINS. Antiinflamm Antiallergy Agents Med Chem (2009) 1.26
Review of S100A9 biology and its role in cancer. Biochim Biophys Acta (2012) 1.19
Divalent metal ion complexes of S100B in the absence and presence of pentamidine. J Mol Biol (2008) 1.09
Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes. Int J Mol Sci (2012) 1.09
High-affinity manganese coordination by human calprotectin is calcium-dependent and requires the histidine-rich site formed at the dimer interface. J Am Chem Soc (2012) 1.08
Calcium ion gradients modulate the zinc affinity and antibacterial activity of human calprotectin. J Am Chem Soc (2012) 1.07
The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infect Immun (2009) 1.03
Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proc Natl Acad Sci U S A (2010) 1.03
Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion. J Biol Chem (2009) 1.01
Statistical analysis of structural characteristics of protein Ca2+-binding sites. J Biol Inorg Chem (2008) 0.99
Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface. J Biol Chem (2015) 0.95
Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. J Am Chem Soc (2015) 0.93
Contributions of the S100A9 C-terminal tail to high-affinity Mn(II) chelation by the host-defense protein human calprotectin. J Am Chem Soc (2013) 0.92
Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. FEMS Immunol Med Microbiol (2008) 0.90
Manganese and microbial pathogenesis: sequestration by the Mammalian immune system and utilization by microorganisms. ACS Chem Biol (2015) 0.88
The Calcium-Dependent Interaction of S100B with Its Protein Targets. Cardiovasc Psychiatry Neurol (2010) 0.88
Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. J Biol Chem (2009) 0.87
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain. J Mol Model (2012) 0.87
The biochemistry and regulation of S100A10: a multifunctional plasminogen receptor involved in oncogenesis. J Biomed Biotechnol (2012) 0.87
Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol (2015) 0.84
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J (2012) 0.83
Modulation of quaternary structure of S100 proteins by calcium ions. Biophys Chem (2010) 0.82
Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys (2016) 0.80
Aggregation of human S100A8 and S100A9 amyloidogenic proteins perturbs proteostasis in a yeast model. PLoS One (2013) 0.80
Molecular interface of S100A8 with cytochrome b558 and NADPH oxidase activation. PLoS One (2012) 0.80
Exploring Differentially Expressed Genes and Natural Antisense Transcripts in Sheep (Ovis aries) Skin with Different Wool Fiber Diameters by Digital Gene Expression Profiling. PLoS One (2015) 0.79
Integration of Diverse Research Methods to Analyze and Engineer Ca-Binding Proteins: From Prediction to Production. Curr Bioinform (2010) 0.79
Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. Oncotarget (2016) 0.79
Calprotectin (S100A8/S100A9) and myeloperoxidase: co-regulators of formation of reactive oxygen species. Toxins (Basel) (2010) 0.79
Role of S100 Proteins in Colorectal Carcinogenesis. Gastroenterol Res Pract (2016) 0.78
Effects of silencing S100A8 and S100A9 with small interfering RNA on the migration of CNE1 nasopharyngeal carcinoma cells. Oncol Lett (2015) 0.78
Calcium Ions Tune the Zinc-Sequestering Properties and Antimicrobial Activity of Human S100A12. Chem Sci (2015) 0.78
Serum calprotectin-a promising diagnostic marker for adult-onset Still's disease. Clin Rheumatol (2015) 0.78
Imaging mass spectrometry for assessing cutaneous wound healing: analysis of pressure ulcers. J Proteome Res (2014) 0.78
Klotho and S100A8/A9 as Discriminative Markers between Pre-Renal and Intrinsic Acute Kidney Injury. PLoS One (2016) 0.78
The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility. J Am Chem Soc (2016) 0.77
Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins. PLoS One (2013) 0.76
Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues. Mol Brain (2016) 0.76
The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus aureus to Resist Calprotectin-Induced Manganese Starvation. PLoS Pathog (2016) 0.76
Binding of transition metals to S100 proteins. Sci China Life Sci (2016) 0.76
Crystallization and calcium/sulfur SAD phasing of the human EF-hand protein S100A2. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
Calcium-induced Tetramerization and Zinc Chelation Shield Human Calprotectin from Degradation by Host and Bacterial Extracellular Proteases. Chem Sci (2015) 0.75
Expression of Calgranulin Genes S100A8, S100A9 and S100A12 Is Modulated by n-3 PUFA during Inflammation in Adipose Tissue and Mononuclear Cells. PLoS One (2017) 0.75
Calprotectin in rheumatic diseases. Exp Biol Med (Maywood) (2016) 0.75
Host-imposed manganese starvation of invading pathogens: two routes to the same destination. Biometals (2015) 0.75
Crystal structure of human S100A8 in complex with zinc and calcium. BMC Struct Biol (2016) 0.75
Calprotectin: Clinical Applications in Pediatrics. J Pediatr Pharmacol Ther (2016) 0.75
Magnetic circular dichroism studies of iron(ii) binding to human calprotectin. Chem Sci (2016) 0.75
The thermodynamics of protein interactions with essential first row transition metals. Biochim Biophys Acta (2015) 0.75
Human calprotectin affects the redox speciation of iron. Metallomics (2017) 0.75
An efficient method for the preparation of preferentially heterodimerized recombinant S100A8/A9 coexpressed in Escherichia coli. Biochem Biophys Rep (2016) 0.75
Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds. J Biol Inorg Chem (2017) 0.75
Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and VSMCs contractility in a rat model. Exp Ther Med (2017) 0.75
Transition metals at the host-pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc. Essays Biochem (2017) 0.75
The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins. Nat Protoc (2007) 3.23
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol (2010) 3.15
Engineered protein scaffolds as next-generation antibody therapeutics. Curr Opin Chem Biol (2009) 2.41
Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity (2010) 2.39
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol Cell (2009) 2.00
Molecular basis of RNA-dependent RNA polymerase II activity. Nature (2007) 1.71
Mechanism of transcriptional stalling at cisplatin-damaged DNA. Nat Struct Mol Biol (2007) 1.32
The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands. J Biol Chem (2004) 1.30
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proc Natl Acad Sci U S A (2003) 1.27
The crystal structure of the bacteriophage PSA endolysin reveals a unique fold responsible for specific recognition of Listeria cell walls. J Mol Biol (2006) 1.26
Binding proteins from alternative scaffolds. J Immunol Methods (2004) 1.26
Temperature and pressure dependence of protein stability: the engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram. Proc Natl Acad Sci U S A (2008) 1.22
Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A (2010) 1.21
Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta (2006) 1.21
Improved affinity of engineered streptavidin for the Strep-tag II peptide is due to a fixed open conformation of the lid-like loop at the binding site. Protein Sci (2002) 1.20
A system for concomitant overexpression of four periplasmic folding catalysts to improve secretory protein production in Escherichia coli. Protein Eng Des Sel (2006) 1.16
Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs. Nat Struct Mol Biol (2005) 1.14
Template misalignment in multisubunit RNA polymerases and transcription fidelity. Mol Cell (2006) 1.13
Structure of the periplasmic chaperone Skp suggests functional similarity with cytosolic chaperones despite differing architecture. Nat Struct Mol Biol (2004) 1.13
Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein D. J Biol Chem (2007) 1.11
A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity. Acta Crystallogr D Biol Crystallogr (2009) 1.10
Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol Biol Cell (2009) 1.08
The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. J Mol Biol (2008) 1.04
The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site. Mol Immunol (2007) 1.02
Structural analysis of the L-alanoyl-D-glutamate endopeptidase domain of Listeria bacteriophage endolysin Ply500 reveals a new member of the LAS peptidase family. Acta Crystallogr D Biol Crystallogr (2008) 1.01
Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site. J Biol Chem (2007) 0.99
Lipocalins in drug discovery: from natural ligand-binding proteins to "anticalins". Drug Discov Today (2005) 0.99
Novel serial positive enrichment technology enables clinical multiparameter cell sorting. PLoS One (2012) 0.98
Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin. J Mol Biol (2003) 0.97
Alternative binding proteins get mature: rivalling antibodies. FEBS J (2008) 0.97
Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition. Antimicrob Agents Chemother (2010) 0.97
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins. Protein Eng Des Sel (2013) 0.97
Crystallographic analysis of an "anticalin" with tailored specificity for fluorescein reveals high structural plasticity of the lipocalin loop region. Proteins (2003) 0.96
Fusion of a recombinant antibody fragment with a homo-amino-acid polymer: effects on biophysical properties and prolonged plasma half-life. Protein Eng Des Sel (2007) 0.96
Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin. Protein Eng Des Sel (2011) 0.95
Identification of potential substrate proteins for the periplasmic Escherichia coli chaperone Skp. Proteomics (2008) 0.95
New insights into the signaling mechanism of the pH-responsive, membrane-integrated transcriptional activator CadC of Escherichia coli. J Biol Chem (2011) 0.93
Anticalins small engineered binding proteins based on the lipocalin scaffold. Methods Enzymol (2012) 0.92
Construction of an artificial receptor protein ("anticalin") based on the human apolipoprotein D. Chembiochem (2004) 0.90
The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops. Proteins (2008) 0.90
Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.89
Solubility engineering and crystallization of human apolipoprotein D. Protein Sci (2005) 0.88
A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. J Mol Biol (2011) 0.88
Tuning ligand affinity, specificity, and folding stability of an engineered lipocalin variant -- a so-called 'anticalin' -- using a molecular random approach. Biophys Chem (2002) 0.87
Extra-domain B in oncofetal fibronectin structurally promotes fibrillar head-to-tail dimerization of extracellular matrix protein. J Biol Chem (2012) 0.87
Functional humanization of an anti-CD30 Fab fragment for the immunotherapy of Hodgkin's lymphoma using an in vitro evolution approach. Protein Eng Des Sel (2005) 0.86
Rational engineering of a fluorescein-binding anticalin for improved ligand affinity. Biol Chem (2005) 0.85
Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family. Protein Sci (2011) 0.84
The periplasmic E. coli chaperone Skp is a trimer in solution: biophysical and preliminary crystallographic characterization. Biol Chem (2004) 0.84
Biochemical analysis of recombinant AlkJ from Pseudomonas putida reveals a membrane-associated, flavin adenine dinucleotide-dependent dehydrogenase suitable for the biosynthetic production of aliphatic aldehydes. Appl Environ Microbiol (2014) 0.84
Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential. Proteins (2013) 0.84
Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn's disease-like ileitis. J Immunol (2012) 0.83
Structure of lumazine protein, an optical transponder of luminescent bacteria. J Mol Biol (2008) 0.83
Crystallographic analysis and structure-guided engineering of NADPH-dependent Ralstonia sp. alcohol dehydrogenase toward NADH cosubstrate specificity. Biotechnol Bioeng (2013) 0.82
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone. J Biol Chem (2013) 0.82
Biochemical characterization of the recombinant human Nogo-A ectodomain. FEBS J (2007) 0.82
Anticalins as an alternative to antibody technology. Expert Opin Biol Ther (2005) 0.82
High-throughput sorting of an Anticalin library via EspP-mediated functional display on the Escherichia coli cell surface. J Mol Biol (2010) 0.82
A photoswitchable neurotransmitter analogue bound to its receptor. Biochemistry (2013) 0.82
High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2. J Am Chem Soc (2009) 0.81
Functional humanization of an anti-CD16 Fab fragment: obstacles of switching from murine {lambda} to human {lambda} or {kappa} light chains. Protein Eng Des Sel (2008) 0.81
A generic strategy for subcloning antibody variable regions from the scFv phage display vector pCANTAB 5 E into pASK85 permits the economical production of F(ab) fragments and leads to improved recombinant immunoglobulin stability. Biosens Bioelectron (2002) 0.81
Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics. Protein Eng Des Sel (2010) 0.81
Deactivation of the E. coli pH stress sensor CadC by cadaverine. J Mol Biol (2012) 0.80
Combinatorial design of an Anticalin directed against the extra-domain b for the specific targeting of oncofetal fibronectin. J Mol Biol (2012) 0.80
NMR structure and dynamics of the engineered fluorescein-binding lipocalin FluA reveal rigidification of beta-barrel and variable loops upon enthalpy-driven ligand binding. Biochemistry (2009) 0.79
Periplasmic chaperones used to enhance functional secretion of proteins in E. coli. Methods Mol Biol (2011) 0.79
Epitope mapping of the neuronal growth inhibitor Nogo-A for the Nogo receptor and the cognate monoclonal antibody IN-1 by means of the SPOT technique. J Mol Recognit (2007) 0.79
β-Barrel scaffolds for the grafting of extracellular loops from G-protein-coupled receptors. Biol Chem (2012) 0.78
Anticalins: the lipocalin family as a novel protein scaffold for the development of next-generation immunotherapies. Expert Rev Clin Immunol (2007) 0.78
Design and characterization of a modular membrane protein anchor to functionalize the moss Physcomitrella patens with extracellular catalytic and/or binding activities. ACS Synth Biol (2014) 0.77
NMR structure of lipoprotein YxeF from Bacillus subtilis reveals a calycin fold and distant homology with the lipocalin Blc from Escherichia coli. PLoS One (2012) 0.77
The crystal structure of human α(1)-microglobulin reveals a potential haem-binding site. Biochem J (2012) 0.77
Structural and biochemical analyses reveal a monomeric state of the bacterial lipocalin Blc. Acta Crystallogr D Biol Crystallogr (2010) 0.77
Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats. Toxicol Appl Pharmacol (2012) 0.77
A novel method for the N-terminal modification of native proteins. Bioconjug Chem (2004) 0.77
Resonance assignments for the 21 kDa engineered fluorescein-binding lipocalin FluA. J Biomol NMR (2003) 0.77
An expression system for the E. coli fermentation of recombinant antibody Fab fragments from mice and rabbits. J AOAC Int (2010) 0.77
The Strep-tag system for one-step affinity purification of proteins from mammalian cell culture. Methods Mol Biol (2015) 0.77
DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis. Eur J Pharmacol (2008) 0.77
Generation of anticalins with specificity for a nonsymmetric phthalic acid ester. Anal Biochem (2002) 0.76
High molecular mass radioimmunoconjugates are promising for intraperitoneal α-emitter immunotherapy due to prolonged retention in the peritoneum. Nucl Med Biol (2012) 0.76
Biosynthesis of a fluorescent protein with extreme pseudo-Stokes shift by introducing a genetically encoded non-natural amino acid outside the fluorophore. J Am Chem Soc (2011) 0.76
High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation. MAbs (2015) 0.76
Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment. Radiother Oncol (2011) 0.76
A system for repertoire cloning and phage display of murine and leporid antibody fragments. J AOAC Int (2010) 0.75
PAS-cal: a generic recombinant peptide calibration standard for mass spectrometry. J Am Soc Mass Spectrom (2014) 0.75
Derivatization of antibody Fab fragments: a designer enzyme for native protein modification. Chembiochem (2014) 0.75
Anticalins in drug development. BioDrugs (2005) 0.75
A HLA-Cw6 specific single-chain antibody fragment (scFv) recognizing a natural killer cell receptor epitope. Mol Immunol (2005) 0.75
Engineering of an orthogonal aminoacyl-tRNA synthetase for efficient incorporation of the non-natural amino acid O-methyl-L-tyrosine using fluorescence-based bacterial cell sorting. J Mol Biol (2010) 0.75
PAS-cal: A repetitive peptide sequence calibration standard for MALDI mass spectrometry. Proteomics (2014) 0.75
Anticalins directed against vascular endothelial growth factor receptor 3 (VEGFR-3) with picomolar affinities show potential for medical therapy and in vivo imaging. Biol Chem (2017) 0.75