Published in Proc Natl Acad Sci U S A on June 19, 2007
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature (2014) 1.89
Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One (2010) 1.89
The WNKs: atypical protein kinases with pleiotropic actions. Physiol Rev (2011) 1.88
The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. Nat Rev Neurosci (2011) 1.66
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res (2008) 1.64
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat Rev Genet (2013) 1.53
LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension. J Biol Chem (2009) 1.14
The secret life of kinases: functions beyond catalysis. Cell Commun Signal (2011) 1.13
Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma. PLoS One (2011) 1.05
WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem (2011) 1.04
Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. Neuro Oncol (2008) 1.00
Molecular epigenetics and genetics in neuro-oncology. Neurotherapeutics (2009) 0.95
With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume. Am J Physiol Cell Physiol (2011) 0.92
WNK1 is required for mitosis and abscission. Proc Natl Acad Sci U S A (2011) 0.91
Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Pharmacogenomics J (2012) 0.86
Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma. Genome Res (2014) 0.85
Epigenetics of neurological cancers. Future Oncol (2009) 0.85
Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. Am J Physiol Renal Physiol (2014) 0.82
A global profile of gene promoter methylation in treatment-naïve urothelial cancer. Epigenetics (2014) 0.80
Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer. BMC Cancer (2016) 0.75
Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas. Oncotarget (2015) 0.75
WNK Kinases in Development and Disease. Curr Top Dev Biol (2016) 0.75
Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan. World J Hepatol (2016) 0.75
WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice. EBioMedicine (2017) 0.75
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (1983) 11.57
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer (2006) 11.22
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res (2005) 7.66
Computational identification of promoters and first exons in the human genome. Nat Genet (2001) 5.88
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst (1998) 5.30
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem (2000) 3.97
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res (2006) 3.83
Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol (2000) 3.61
A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop. Cancer Res (2005) 3.35
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene (2001) 2.48
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
A genomic scanning method for higher organisms using restriction sites as landmarks. Proc Natl Acad Sci U S A (1991) 2.08
Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype. Oncogene (1999) 1.91
Properties of WNK1 and implications for other family members. J Biol Chem (2005) 1.89
Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. Am J Pathol (2002) 1.61
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet (2002) 1.48
Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol (2004) 1.39
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade "oligodendroglioma". J Neuropathol Exp Neurol (2002) 1.35
The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors. Cancer (2005) 1.34
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res (2000) 1.33
Genetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implications. Front Biosci (2000) 1.29
Overview of cancer epigenetics. Semin Hematol (2005) 1.12
Chromosomal imbalances detected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomas. Genes Chromosomes Cancer (2005) 1.10
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res (2005) 1.10
WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens (2004) 1.04
Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci. Blood (2001) 1.01
Molecular pathology and clinical characteristics of oligodendroglial neoplasms. Ann Neurol (2005) 0.91
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell (2006) 21.66
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
A model of molecular interactions on short oligonucleotide microarrays. Nat Biotechnol (2003) 9.98
Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81
A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med (2014) 9.19
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell (2011) 6.43
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol (2010) 6.30
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol (2008) 4.39
NFKBIA deletion in glioblastomas. N Engl J Med (2010) 3.96
Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol (2006) 3.76
A multigene predictor of outcome in glioblastoma. Neuro Oncol (2009) 3.57
Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol (2013) 3.52
Clinical validation of a next-generation sequencing screen for mutational hotspots in 46 cancer-related genes. J Mol Diagn (2013) 3.36
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34
FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res (2006) 3.28
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol (2011) 3.23
Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res (2005) 3.10
Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes Chromosomes Cancer (2004) 3.05
Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res (2007) 3.05
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res (2006) 2.70
The Human Epigenome Browser at Washington University. Nat Methods (2011) 2.62
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet (2005) 2.51
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev (2011) 2.48
Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia (2011) 2.32
NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology. J Natl Compr Canc Netw (2011) 2.24
Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res (2006) 2.18
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. Cancer (2004) 2.11
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group. J Clin Oncol (2007) 2.01
Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro Oncol (2010) 1.99
Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol (2008) 1.94
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem (2006) 1.93
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma. Clin Cancer Res (2006) 1.91
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article. J Neurosurg (2010) 1.85
YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res (2005) 1.81
VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol (2008) 1.77
Exploring long-range genome interactions using the WashU Epigenome Browser. Nat Methods (2013) 1.71
Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism. Crit Care Med (2008) 1.69
MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma. Neuro Oncol (2009) 1.69
Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol (2009) 1.69
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64
IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol (2013) 1.63
HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res (2009) 1.61
Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma. J Mol Diagn (2012) 1.59
Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res (2005) 1.57
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes Dev (2013) 1.55
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A (2007) 1.54
International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors. Neuro Oncol (2011) 1.53
Association and interactions between DNA repair gene polymorphisms and adult glioma. Cancer Epidemiol Biomarkers Prev (2009) 1.51
Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels. Neoplasia (2010) 1.51
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res (2008) 1.51
Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma? Neuro Oncol (2011) 1.50
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet (2002) 1.48
Utility of MRI in spinal arteriovenous fistula. Neurology (2012) 1.46
DNA motifs associated with aberrant CpG island methylation. Genomics (2006) 1.40
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes. PLoS One (2011) 1.34
General principles in the medical and surgical management of spinal infections: a multidisciplinary approach. Neurosurg Focus (2004) 1.34
The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria. Am J Surg Pathol (2004) 1.33
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res (2005) 1.33
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro Oncol (2011) 1.31
Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods. Genome Res (2013) 1.31
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy. Clin Cancer Res (2006) 1.30
Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors. BMC Med Genomics (2011) 1.29
Long-term anti-inflammatory and antihistamine medication use and adult glioma risk. Cancer Epidemiol Biomarkers Prev (2008) 1.28
Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. BMC Genomics (2008) 1.25
Polymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma. Clin Cancer Res (2008) 1.25
Bayesian ensemble methods for survival prediction in gene expression data. Bioinformatics (2010) 1.24
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res (2010) 1.21
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Proc Natl Acad Sci U S A (2013) 1.20
Aggregation of cancer in first-degree relatives of patients with glioma. Cancer Epidemiol Biomarkers Prev (2007) 1.17
Exploratory analysis of the copy number alterations in glioblastoma multiforme. PLoS One (2008) 1.17
Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. Neuro Oncol (2012) 1.17
Using the molecular classification of glioblastoma to inform personalized treatment. J Pathol (2014) 1.17
Genome-scale DNA methylation analysis. Epigenomics (2010) 1.15
FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res (2010) 1.14
Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol (2012) 1.13
Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res (2007) 1.12
Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst (2005) 1.12
Genome-epigenome interactions in cancer. Hum Mol Genet (2007) 1.12
IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas. Acta Neuropathol (2015) 1.11