Published in J Biol Chem on June 09, 2006
The epigenomics of cancer. Cell (2007) 30.91
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A (2008) 2.53
Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res (2009) 2.31
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest (2010) 2.00
Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncol (2009) 1.90
What is the malignant nature of human ductal carcinoma in situ? Nat Rev Cancer (2010) 1.86
Tumor microenvironment and progression. J Surg Oncol (2011) 1.54
Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A (2013) 1.31
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One (2010) 1.28
Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line. Mol Cancer Res (2009) 1.27
Regulation and Role of EZH2 in Cancer. Cancer Res Treat (2014) 1.27
Epigenomics and breast cancer. Pharmacogenomics (2008) 1.23
EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development. Mod Pathol (2011) 1.21
Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors. PLoS One (2010) 1.17
A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Res (2009) 1.15
HOX proteins and leukemia. Int J Clin Exp Pathol (2008) 1.14
Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. Oncogene (2009) 1.06
Molecular characterisation of cell line models for triple-negative breast cancers. BMC Genomics (2012) 1.03
Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients. Mol Med (2010) 1.03
Epigenetic regulation in estrogen receptor positive breast cancer--role in treatment response. J Mammary Gland Biol Neoplasia (2010) 1.02
Cancer as a manifestation of aberrant chromatin structure. Cancer J (2007) 1.01
Chromatin remodeling in mammary gland differentiation and breast tumorigenesis. Cold Spring Harb Perspect Biol (2010) 0.98
Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease. PLoS One (2012) 0.98
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res (2009) 0.97
A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma. Epigenetics (2013) 0.96
The dual roles of homeobox genes in vascularization and wound healing. Cell Adh Migr (2012) 0.92
Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer. Mol Cell Endocrinol (2013) 0.87
Seed in soil, with an epigenetic view. Biochim Biophys Acta (2008) 0.86
p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer. Mol Med (2008) 0.85
Germline DNA copy number aberrations identified as potential prognostic factors for breast cancer recurrence. PLoS One (2013) 0.85
Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer. J Cancer Res Clin Oncol (2009) 0.84
Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis. Breast Cancer Res (2012) 0.84
Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation. J Biol Chem (2012) 0.83
The role of epigenetic alterations in papillary thyroid carcinogenesis. J Thyroid Res (2011) 0.83
Wip1 phosphatase in breast cancer. Oncogene (2014) 0.83
Homeobox Gene Deregulation: Impact on the Hallmarks of Cancer. Cancer Hallm (2013) 0.82
Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes. PLoS One (2014) 0.80
Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers. PLoS One (2015) 0.79
Investigation of HOXA9 promoter methylation as a biomarker to distinguish oral cancer patients at low risk of neck metastasis. BMC Cancer (2014) 0.78
The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation. Chin J Cancer (2013) 0.77
Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer. Breast Cancer (Auckl) (2016) 0.77
Induced pluripotent stem cell technology for dissecting the cancer epigenome. Cancer Sci (2015) 0.77
A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues. Expert Opin Biol Ther (2014) 0.77
SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73. Cell Signal (2016) 0.75
BRCA1: linking HOX to breast cancer suppression. Breast Cancer Res (2010) 0.75
MK3 modulation affects BMI1-dependent and independent cell cycle check-points. PLoS One (2015) 0.75
Willing to Be Involved in Cancer. Genes (Basel) (2016) 0.75
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
Distinct sets of genetic alterations in melanoma. N Engl J Med (2005) 17.26
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell (2006) 16.05
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature (2012) 8.13
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res (2009) 5.68
A prediction-based resampling method for estimating the number of clusters in a dataset. Genome Biol (2002) 5.15
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol (2006) 4.71
Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst (2010) 4.57
A comparison study: applying segmentation to array CGH data for downstream analyses. Bioinformatics (2005) 4.57
Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst (2003) 3.65
Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. Cancer Cell (2007) 3.44
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34
Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene (2005) 2.99
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res (2007) 2.94
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol (2007) 2.64
The Human Epigenome Browser at Washington University. Nat Methods (2011) 2.62
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther (2006) 2.55
Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell (2007) 2.55
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A (2008) 2.53
Improving melanoma classification by integrating genetic and morphologic features. PLoS Med (2008) 2.52
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet (2005) 2.51
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov (2012) 2.51
High-resolution genomic and expression analyses of copy number alterations in breast tumors. Genes Chromosomes Cancer (2008) 2.46
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol (2006) 2.39
Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors. Cancer Res (2003) 2.34
Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res (2006) 2.18
High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization. Carcinogenesis (2004) 2.13
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol (2007) 2.07
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res (2003) 2.03
Bagging to improve the accuracy of a clustering procedure. Bioinformatics (2003) 1.91
Bladder cancer stage and outcome by array-based comparative genomic hybridization. Clin Cancer Res (2005) 1.85
Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. Hum Mol Genet (2004) 1.80
Gene expression and angiotropism in primary CNS lymphoma. Blood (2006) 1.79
Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth. Proc Natl Acad Sci U S A (2007) 1.78
Exploring long-range genome interactions using the WashU Epigenome Browser. Nat Methods (2013) 1.71
Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. Cancer Res (2003) 1.71
Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res (2005) 1.71
Shaping of tumor and drug-resistant genomes by instability and selection. Oncogene (2003) 1.70
Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism. Crit Care Med (2008) 1.69
Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol (2009) 1.69
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors. Cancer Res (2003) 1.67
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell (2004) 1.66
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer (2011) 1.58
High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays. Am J Pathol (2003) 1.57
Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models. Clin Cancer Res (2012) 1.55
Tumor microenvironment and progression. J Surg Oncol (2011) 1.54
Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma. Oncogene (2003) 1.52
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res (2008) 1.51
Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood (2007) 1.48
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet (2002) 1.48
p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila) (2011) 1.45
DNA motifs associated with aberrant CpG island methylation. Genomics (2006) 1.40
Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology (2008) 1.35
Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer. Cancer Res (2007) 1.34
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes. PLoS One (2011) 1.34
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res (2005) 1.33
Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods. Genome Res (2013) 1.31
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro Oncol (2011) 1.31
Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A (2013) 1.31
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest (2007) 1.30
Chromosomal instability in microsatellite-unstable and stable colon cancer. Clin Cancer Res (2006) 1.28
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem (2006) 1.27
3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis (2005) 1.26
Genetic variants associated with breast size also influence breast cancer risk. BMC Med Genet (2012) 1.26
Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol (2006) 1.24
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res (2010) 1.21
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers. Breast Cancer Res (2007) 1.15
p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Res (2005) 1.15
Genome-scale DNA methylation analysis. Epigenomics (2010) 1.15