Published in Development on August 26, 2009
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science (2011) 2.69
Derivation of haploid embryonic stem cells from mouse embryos. Nature (2011) 2.66
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol (2013) 2.49
Extrinsic regulation of pluripotent stem cells. Nature (2010) 2.39
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
Control of ground-state pluripotency by allelic regulation of Nanog. Nature (2012) 2.25
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature (2014) 2.19
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell (2012) 2.15
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol (2011) 2.13
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Making the blastocyst: lessons from the mouse. J Clin Invest (2010) 1.85
Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Nat Cell Biol (2013) 1.81
Blimp1 expression predicts embryonic stem cell development in vitro. Curr Biol (2011) 1.76
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol (2014) 1.76
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis. Dev Cell (2015) 1.75
Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell (2013) 1.74
FGF signalling: diverse roles during early vertebrate embryogenesis. Development (2010) 1.60
Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state. Development (2010) 1.58
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development (2010) 1.51
Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. Elife (2013) 1.49
FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development (2012) 1.47
Human hypoblast formation is not dependent on FGF signalling. Dev Biol (2011) 1.46
Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS One (2014) 1.44
Totipotent embryonic stem cells arise in ground-state culture conditions. Cell Rep (2013) 1.43
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell (2013) 1.42
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
Establishment of trophoblast stem cells under defined culture conditions in mice. PLoS One (2014) 1.39
Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes. Mol Cell (2012) 1.36
Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo. Development (2011) 1.33
The PluriNetWork: an electronic representation of the network underlying pluripotency in mouse, and its applications. PLoS One (2010) 1.33
Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports (2013) 1.31
Current perspectives of the signaling pathways directing neural crest induction. Cell Mol Life Sci (2012) 1.30
Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines. PLoS One (2009) 1.29
Pluripotent stem cells: private obsession and public expectation. EMBO Mol Med (2010) 1.24
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J (2012) 1.23
The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos. Development (2012) 1.23
Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming. Cell Rep (2014) 1.23
Anatomy of a blastocyst: cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo. Genesis (2013) 1.21
The liberation of embryonic stem cells. PLoS Genet (2011) 1.20
microRNAs modulate iPS cell generation. RNA (2011) 1.19
Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming. Cell Stem Cell (2014) 1.19
A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. Sci Rep (2012) 1.18
A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst. Development (2010) 1.18
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
Accessing naïve human pluripotency. Curr Opin Genet Dev (2012) 1.13
GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell (2014) 1.12
Auxetic nuclei in embryonic stem cells exiting pluripotency. Nat Mater (2014) 1.11
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum Mol Genet (2012) 1.07
A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLoS Genet (2012) 1.05
Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development (2014) 1.05
Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell (2014) 1.04
Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development (2012) 1.04
Mapping the route from naive pluripotency to lineage specification. Philos Trans R Soc Lond B Biol Sci (2014) 1.01
HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet (2014) 1.00
Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harb Perspect Biol (2012) 1.00
Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol (2011) 1.00
Wnt pathway regulation of embryonic stem cell self-renewal. Cold Spring Harb Perspect Biol (2012) 0.99
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency. Proc Natl Acad Sci U S A (2012) 0.99
Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. Nat Commun (2015) 0.99
Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. Development (2011) 0.98
Derivation and characterization of mouse embryonic stem cells from permissive and nonpermissive strains. Nat Protoc (2014) 0.98
Signaling networks in human pluripotent stem cells. Curr Opin Cell Biol (2012) 0.97
The germ cell determinant Blimp1 is not required for derivation of pluripotent stem cells. Cell Stem Cell (2012) 0.97
Developmental plasticity is bound by pluripotency and the Fgf and Wnt signaling pathways. Cell Rep (2012) 0.97
Switching on pluripotency: a perspective on the biological requirement of Nanog. Philos Trans R Soc Lond B Biol Sci (2011) 0.97
Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst. Cell Rep (2015) 0.96
Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass. Stem Cell Reports (2016) 0.96
Tcf15 primes pluripotent cells for differentiation. Cell Rep (2013) 0.95
Induced pluripotent stem cells: what lies beyond the paradigm shift. Exp Biol Med (Maywood) (2010) 0.95
Medaka cleavage embryos are capable of generating ES-like cell cultures. Int J Biol Sci (2011) 0.94
Stemness as a cell default state. EMBO Rep (2012) 0.94
Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development. Development (2012) 0.92
Transcription factor heterogeneity and epiblast pluripotency. Philos Trans R Soc Lond B Biol Sci (2011) 0.92
The function of e-cadherin in stem cell pluripotency and self-renewal. Genes (Basel) (2011) 0.92
Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells. Stem Cells (2012) 0.91
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network. Cell Mol Life Sci (2015) 0.90
Modulation of pluripotency in the porcine embryo and iPS cells. PLoS One (2012) 0.90
Establishment of epigenetic patterns in development. Chromosoma (2012) 0.90
PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst. Stem Cells (2013) 0.90
Troika of the mouse blastocyst: lineage segregation and stem cells. Curr Stem Cell Res Ther (2012) 0.90
Neuronatin promotes neural lineage in ESCs via Ca(2+) signaling. Stem Cells (2010) 0.89
Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models. Bioessays (2011) 0.89
Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway. Stem Cells (2013) 0.89
The birth of embryonic pluripotency. Philos Trans R Soc Lond B Biol Sci (2014) 0.88
Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst. Development (2013) 0.88
Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol Reprod (2013) 0.88
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes Dev (2012) 0.87
Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Stem Cells (2013) 0.87
Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells. Sci Rep (2014) 0.87
Cell lineage allocation within the inner cell mass of the mouse blastocyst. Results Probl Cell Differ (2012) 0.87
The different shades of mammalian pluripotent stem cells. Hum Reprod Update (2010) 0.86
The molecular underpinnings of totipotency. Philos Trans R Soc Lond B Biol Sci (2014) 0.86
Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst. Nat Commun (2016) 0.85
Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell (1998) 19.05
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell (2003) 17.72
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature (1988) 13.21
Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature (2007) 11.72
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature (1988) 7.61
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15
Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature (1984) 6.54
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (2007) 5.62
Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52
Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development (2005) 4.89
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
Immunosurgery of mouse blastocyst. Proc Natl Acad Sci U S A (1975) 4.33
Preservation of hamster oocytes to assay the fertilizing capacity of human spermatozoa. J Reprod Fertil (1982) 4.26
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol (1999) 4.00
Defined conditions for neural commitment and differentiation. Methods Enzymol (2003) 3.99
Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol (1994) 3.88
Reactivation of the paternal X chromosome in early mouse embryos. Science (2004) 3.59
GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol (1996) 3.46
The origin and efficient derivation of embryonic stem cells in the mouse. Proc Natl Acad Sci U S A (1997) 3.39
Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci U S A (1998) 3.27
X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 3.25
Determining the stage of the estrous cycle in the mouse by the appearance of the vagina. Biol Reprod (1973) 3.14
Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn (2004) 3.13
Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development (2007) 2.71
Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell (1998) 2.64
Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med (2009) 2.26
A germ cell origin of embryonic stem cells? Development (2005) 2.09
Genesis of embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (2003) 1.97
Rapid loss of Oct-4 and pluripotency in cultured rodent blastocysts and derivative cell lines. Biol Reprod (2003) 1.91
Reflections on the biology of embryonic stem (ES) cells. Int J Dev Biol (1997) 1.58
Strain difference in establishment of mouse embryonic stem (ES) cell lines. Int J Dev Biol (1994) 1.55
Regeneration of endoderm from primitive ectoderm in the mouse embryo: fact or artifact? J Embryol Exp Morphol (1985) 1.53
Expression and function of FGF-4 in peri-implantation development in mouse embryos. Development (1994) 1.51
Parameters influencing derivation of embryonic stem cells from murine embryos. Genesis (2008) 1.43
Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK. Oncogene (2007) 1.42
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos. Nat Genet (2008) 1.39
Derivation and propagation of embryonic stem cells in serum- and feeder-free culture. Methods Mol Biol (2006) 1.19
Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Development (2000) 1.16
Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-3. Stem Cells (2007) 1.11
Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis. Mech Dev (1996) 1.01
msd is required for mesoderm induction in mice. Development (1994) 0.95
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47
Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol (2003) 9.41
Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol (2005) 9.12
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell (2009) 6.77
Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60
The transcriptional and epigenomic foundations of ground state pluripotency. Cell (2012) 5.87
An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell (2011) 5.75
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (2007) 5.62
Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49
Capturing pluripotency. Cell (2008) 5.08
Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol (2002) 5.00
Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene (2004) 4.40
Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38
Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 3.42
Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell (2009) 3.27
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07
Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03
Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A (2003) 2.86
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64
Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. Curr Biol (2002) 2.64
Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol (2013) 2.49
Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med (2009) 2.26
Genesis of embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (2003) 1.97
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Adherent neural stem (NS) cells from fetal and adult forebrain. Cereb Cortex (2006) 1.88
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol (2010) 1.86
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab (2009) 1.79
Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci (2008) 1.62
The origin and identity of embryonic stem cells. Development (2011) 1.60
Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. J Cell Sci (2002) 1.58
Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state. Development (2010) 1.58
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development (2010) 1.51
CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One (2009) 1.50
Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor. EMBO J (2013) 1.46
Human hypoblast formation is not dependent on FGF signalling. Dev Biol (2011) 1.46
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One (2012) 1.46
Parameters influencing derivation of embryonic stem cells from murine embryos. Genesis (2008) 1.43
The nature of embryonic stem cells. Annu Rev Cell Dev Biol (2014) 1.40
'No' to ban on stem-cell patents. Nature (2011) 1.39
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun (2012) 1.37
The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Neurobiol Dis (2012) 1.35
Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells (2012) 1.33
Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports (2013) 1.31
A PiggyBac-based recessive screening method to identify pluripotency regulators. PLoS One (2011) 1.30
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J (2013) 1.28
Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Stem Cells (2007) 1.23
The liberation of embryonic stem cells. PLoS Genet (2011) 1.20
Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation. Mol Cell Neurosci (2008) 1.20
Germline potential of parthenogenetic haploid mouse embryonic stem cells. Development (2012) 1.19
In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective. Drug Metab Dispos (2009) 1.15
Tripotential differentiation of adherently expandable neural stem (NS) cells. PLoS One (2007) 1.13
Interventional nephrology in Puerto Rico. Semin Dial (2006) 1.10
Rebuilding pluripotency from primordial germ cells. Stem Cell Reports (2013) 1.09
Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells. J Cell Sci (2011) 1.07
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development (2010) 1.07
A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLoS Genet (2012) 1.05
Stem cells: Fusion brings down barriers. Nature (2003) 1.05
Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. Glia (2011) 0.95
The mammalian germline as a pluripotency cycle. Development (2013) 0.93
Therapeutic bilateral lung lavage in a child with pulmonary alveolar proteinosis. Pediatr Crit Care Med (2010) 0.86
A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. PLoS One (2013) 0.86
Unequal segregation of parental chromosomes in embryonic stem cell hybrids. Mol Reprod Dev (2005) 0.85
Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans. Drug Metab Dispos (2014) 0.84
Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells. J Biomol Screen (2012) 0.83
Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci (2013) 0.83
Differentiation of human induced pluripotent stem cells into brown and white adipocytes: role of Pax3. Stem Cells (2014) 0.82
Neural stem cells engrafted in the adult brain fuse with endogenous neurons. Stem Cells Dev (2012) 0.82
Exploitation of adherent neural stem cells in basic and applied neurobiology. Regen Med (2006) 0.81
Tethered spheroids as an in vitro hepatocyte model for drug safety screening. Biomaterials (2011) 0.81
Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid. Neurosci Res (2011) 0.81
De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes. Curr Drug Metab (2012) 0.80
Free radical metabolism of raloxifene in human liver microsomes. Xenobiotica (2012) 0.79
Inter- and intramouse heterogeneity of radiation response for a growing paired organ. Radiat Res (2008) 0.78
Human embryonic stem cells. Science (2005) 0.77
A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry. Rapid Commun Mass Spectrom (2008) 0.77
Looking inwards: opening a window onto human development. Development (2015) 0.76
LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume. J Pharm Biomed Anal (2013) 0.76
Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes. Drug Metab Dispos (2013) 0.76
Galactosylated cellulosic sponge for multi-well drug safety testing. Biomaterials (2011) 0.76
Stem cells and regeneration: a special issue. Development (2013) 0.75
Human embryonic stem cells: prospects for human health - a 1-day international symposium held at the University of Sheffield. J Anat (2002) 0.75
Retraction. Nature (2014) 0.75
Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.75
An unusual tumor presentation. Int Surg (2007) 0.75
Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560. J Mass Spectrom (2006) 0.75
Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell (2015) 0.75