Published in FEBS Lett on June 26, 2007
Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem (2011) 1.30
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line. Biochem Pharmacol (2011) 1.01
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol (2012) 0.86
Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295. Biochemistry (2009) 0.86
RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. PLoS One (2013) 0.84
Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands. J Med Chem (2014) 0.77
A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ. Biochem J (2015) 0.76
Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders. Adv Pharmacol (2016) 0.75
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorg Med Chem (2014) 0.75
Protein Kinase C δ: a Gatekeeper of Immune Homeostasis. J Clin Immunol (2016) 0.75
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat Struct Mol Biol (2009) 3.37
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep (2009) 2.55
Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics (2004) 2.43
PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol (2010) 2.41
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol (2010) 2.24
Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect. Proteomics (2003) 2.17
Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol (2009) 2.15
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep (2008) 2.09
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol (2003) 1.90
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell (2013) 1.90
The late endosome is essential for mTORC1 signaling. Mol Biol Cell (2010) 1.79
PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J (2005) 1.75
The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. Biochem J (2008) 1.74
Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J (2003) 1.69
PKC epsilon controls the traffic of beta1 integrins in motile cells. EMBO J (2002) 1.67
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J (2006) 1.61
The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol (2008) 1.61
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell (2004) 1.57
PKC controls HGF-dependent c-Met traffic, signalling and cell migration. EMBO J (2004) 1.51
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J Cell Biol (2008) 1.48
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol (2002) 1.35
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells. PLoS One (2008) 1.31
mTORC2 targets AGC kinases through Sin1-dependent recruitment. Biochem J (2011) 1.18
Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell (2005) 1.16
Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met. J Biol Chem (2003) 1.13
Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer. Cancer Res (2006) 1.12
Protein kinase C intervention: the state of play. Curr Opin Cell Biol (2009) 1.11
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer (2008) 1.11
Laser capture microdissection and two-dimensional polyacrylamide gel electrophoresis: evaluation of tissue preparation and sample limitations. Am J Pathol (2002) 1.10
Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma. Proteomics (2006) 1.10
Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. Mol Cell Biol (2003) 1.08
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci Signal (2009) 1.08
A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse. Sci Signal (2011) 1.05
Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides. FEBS Lett (2002) 1.04
Spatially specific expression of Hoxb4 is dependent on the ubiquitous transcription factor NFY. Development (2002) 1.03
Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae. Biochem J (2002) 1.02
PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. PLoS One (2011) 1.00
PIKfyve negatively regulates exocytosis in neurosecretory cells. J Biol Chem (2007) 0.99
Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. PLoS One (2011) 0.99
The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors. J Biol Chem (2008) 0.99
Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta. Biochem J (2002) 0.98
Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ. J Biol Chem (2002) 0.97
PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Nat Cell Biol (2003) 0.97
PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly. Cell Signal (2006) 0.96
Approaches to define antigen receptor-induced serine kinase signal transduction pathways. J Biol Chem (2003) 0.95
Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1. J Biol Chem (2003) 0.95
Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry. Mol Cell Biol (2011) 0.94
Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. J Biol Chem (2010) 0.92
Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma. Proteomics (2006) 0.92
ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines. J Cell Sci (2013) 0.92
Control of MT1-MMP transport by atypical PKC during breast-cancer progression. Proc Natl Acad Sci U S A (2014) 0.91
Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). J Biol Chem (2003) 0.91
Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J (2003) 0.90
Protein kinase C epsilon in cell division: control of abscission. Cell Cycle (2009) 0.89
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J (2013) 0.88
Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. Mol Cell Biol (2003) 0.87
Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat Struct Mol Biol (2010) 0.87
Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration. J Cell Sci (2012) 0.86
Labeling and identification of LNCaP cell surface proteins: a pilot study. Prostate (2007) 0.85
Acute regulation of PDK1 by a complex interplay of molecular switches. Biochem Soc Trans (2014) 0.83
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha. Cell Signal (2006) 0.83
The tumour suppressor RASSF1A is a novel substrate of PKC. FEBS Lett (2008) 0.83
Identification of pro-interleukin 16 as a novel target of MAP kinases in activated T lymphocytes. Eur J Immunol (2004) 0.82
The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta. Biochem J (2006) 0.82
Protein kinase C - a family of protein kinases, allosteric effectors or both? Adv Enzyme Regul (2009) 0.81
Manipulating signal delivery - plasma-membrane ERK activation in aPKC-dependent migration. J Cell Sci (2010) 0.81
Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens. Clin Cancer Res (2004) 0.81
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis (2013) 0.80
Site recognition and substrate screens for PKN family proteins. Biochem J (2011) 0.80
A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif. Sci Signal (2013) 0.80
A high-content, cell-based screen identifies micropolyin, a new inhibitor of microtubule dynamics. Chem Biol Drug Des (2009) 0.79
Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations. Biochem J (2010) 0.78
Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae. J Cell Sci (2006) 0.78
PKCzetaII is a target for degradation through the tumour suppressor protein pVHL. FEBS Lett (2007) 0.78
Ceramide kinase profiling by mass spectrometry reveals a conserved phosphorylation pattern downstream of the catalytic site. J Proteome Res (2010) 0.77
Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid. Int J Cancer (2011) 0.77
PKCalpha reduces the lipid kinase activity of the p110alpha/p85alpha PI3K through the phosphorylation of the catalytic subunit. Biochem Biophys Res Commun (2005) 0.77
Identification of proteins regulated by interferon-alpha in resistant and sensitive malignant melanoma cell lines. Proteomics (2004) 0.76
Pseudokinase drug intervention: a potentially poisoned chalice. Biochem Soc Trans (2013) 0.76
The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. Protein Cell (2011) 0.76
Correction: HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer. PLoS Biol (2016) 0.75
Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts. Mol Cell Proteomics (2012) 0.75
Functional implications of assigned, assumed and assembled PKC structures. Biochem Soc Trans (2014) 0.75
Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun (2016) 0.75
Localised interventions in cellular processes. Biochim Biophys Acta (2013) 0.75