p63: revving up epithelial stem-cell potential.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMID 17603506)

Published in Nat Cell Biol on July 01, 2007

Authors

Cédric Blanpain, Elaine Fuchs

Articles citing this

3D In vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells. Stem Cell Reports (2014) 2.42

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75

Tracheal Basal cells: a facultative progenitor cell pool. Am J Pathol (2010) 1.53

Context-dependent differentiation of multipotential keratin 14-expressing tracheal basal cells. Am J Respir Cell Mol Biol (2010) 1.20

The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205. J Biol Chem (2012) 1.19

Mechanisms regulating epidermal stem cells. EMBO J (2012) 1.07

p63 regulates olfactory stem cell self-renewal and differentiation. Neuron (2011) 1.06

Epigenetic regulation of skin: focus on the Polycomb complex. Cell Mol Life Sci (2012) 0.99

Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha. Development (2010) 0.96

p63 expression correlates with sensitivity to the Eg5 inhibitor ZD4877 in bladder cancer cells. Cancer Biol Ther (2012) 0.96

The lectin KM+ induces corneal epithelial wound healing in rabbits. Int J Exp Pathol (2009) 0.94

Epigenetic regulation of epidermal differentiation. Cold Spring Harb Perspect Med (2014) 0.91

An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models. J Exp Clin Cancer Res (2011) 0.91

Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90

Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol (2008) 0.90

Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia (2013) 0.87

Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest (2012) 0.84

Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells. Proc Natl Acad Sci U S A (2008) 0.83

OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation. Cell Death Dis (2014) 0.83

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Cancer Lett (2015) 0.81

New technique for culturing corneal epithelial cells of normal mice. Mol Vis (2009) 0.80

Restoration of the rabbit corneal surface after total epithelial debridement and complete limbal excision. Braz J Med Biol Res (2012) 0.78

p63 expression in adamantinoma. Virchows Arch (2011) 0.78

Fucoidan promotes the reconstruction of skin equivalents. Korean J Physiol Pharmacol (2014) 0.77

Dynamic Change in p63 Protein Expression during Implantation of Urothelial Cancer Clusters. Neoplasia (2015) 0.77

Maintenance of the corneal epithelium is carried out by germinative cells of its basal stratum and not by presumed stem cells of the limbus. Braz J Med Biol Res (2014) 0.76

The Antigenic Determinant That Defines Thymic Nurse Cells Is Expressed by Thymic Epithelial Progenitor Cells. Front Cell Dev Biol (2014) 0.76

Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS One (2013) 0.75

Daughters of the Enamel Organ: Development, Fate, and Function of the Stratum Intermedium, Stellate Reticulum, and Outer Enamel Epithelium. Stem Cells Dev (2016) 0.75

Spatiotemporal Expression of p63 in Mouse Epidermal Commitment. Int J Mol Sci (2015) 0.75

Articles by these authors

(truncated to the top 100)

Defining the epithelial stem cell niche in skin. Science (2003) 14.93

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79

Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95

Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67

Distinct stem cells contribute to mammary gland development and maintenance. Nature (2011) 6.32

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30

A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51

A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40

Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02

Defining the mode of tumour growth by clonal analysis. Nature (2012) 5.02

Sticky business: orchestrating cellular signals at adherens junctions. Cell (2003) 4.91

Links between signal transduction, transcription and adhesion in epithelial bud development. Nature (2003) 4.88

Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29

Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27

Dynamics between stem cells, niche, and progeny in the hair follicle. Cell (2011) 4.14

Epithelial stem cells: turning over new leaves. Cell (2007) 4.10

Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev Cell (2002) 4.01

Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med (2003) 3.91

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90

Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88

NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79

Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat Cell Biol (2003) 3.77

Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol (2004) 3.70

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67

Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature (2011) 3.64

Interferon-γ links ultraviolet radiation to melanomagenesis in mice. Nature (2011) 3.56

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell (2007) 3.55

Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51

A role for skin gammadelta T cells in wound repair. Science (2002) 3.51

Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature (2012) 3.44

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature (2011) 3.25

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16

In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol (2003) 3.08

Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell (2008) 3.07

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol (2008) 3.07

Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06

GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev (2003) 2.97

Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97

ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell (2008) 2.94

Stem cells in the skin: waste not, Wnt not. Genes Dev (2003) 2.80

Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell (2011) 2.80

Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79

Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat Rev Mol Cell Biol (2004) 2.79

Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78

Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73

Catenins: keeping cells from getting their signals crossed. Dev Cell (2006) 2.70

Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (2002) 2.69

p120-catenin mediates inflammatory responses in the skin. Cell (2006) 2.66

ACF7: an essential integrator of microtubule dynamics. Cell (2003) 2.66

DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol Cell (2012) 2.66

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev (2011) 2.63

The hair cycle. J Cell Sci (2006) 2.58

DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol (2010) 2.48

RNAi screens in mice identify physiological regulators of oncogenic growth. Nature (2013) 2.46

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41

Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell (2011) 2.36

Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell (2012) 2.35

Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26

Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A (2011) 2.24

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol (2009) 2.24

Stem cells of the skin epithelium. Proc Natl Acad Sci U S A (2003) 2.20

Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. J Cell Biol (2007) 2.16

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 2.14

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A (2011) 2.08

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility. J Clin Invest (2009) 2.06

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med (2010) 2.01

Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell (2012) 1.99

Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99

A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91

Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol (2012) 1.89

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell (2011) 1.83

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A (2006) 1.77

Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell (2009) 1.77

Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. Dev Cell (2013) 1.70

A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol (2004) 1.63

Isolation and culture of epithelial stem cells. Methods Mol Biol (2009) 1.63

DNA damage response in adult stem cells: pathways and consequences. Nat Rev Mol Cell Biol (2011) 1.57

Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. J Cell Biol (2011) 1.56

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development (2010) 1.55

Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science (2014) 1.53

Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51

The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47

Structure and transcription of the human m3 muscarinic receptor gene. Am J Respir Cell Mol Biol (2002) 1.47

Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors. J Biol Chem (2002) 1.44

Mesp1: a key regulator of cardiovascular lineage commitment. Circ Res (2010) 1.43

Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci (2006) 1.42

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A (2008) 1.40

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol (2006) 1.38

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol (2011) 1.37

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A (2008) 1.37

The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregation. Stem Cells (2008) 1.37

A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev Cell (2003) 1.35

SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev (2014) 1.34