Published in Genes Dev on May 15, 2003
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69
Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature (2005) 4.16
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet (2004) 3.21
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell (2009) 2.74
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci U S A (2004) 2.53
Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31
Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol (2005) 2.21
Stem cells of the skin epithelium. Proc Natl Acad Sci U S A (2003) 2.20
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10
The basement membrane of hair follicle stem cells is a muscle cell niche. Cell (2011) 1.88
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. J R Soc Interface (2007) 1.68
The R-spondin protein family. Genome Biol (2012) 1.62
Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin. Oncogene (2007) 1.53
Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol (2007) 1.52
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing. Biol Cell (2005) 1.43
Vitamin D receptor is essential for normal keratinocyte stem cell function. Proc Natl Acad Sci U S A (2007) 1.42
Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A (2005) 1.41
Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling. Semin Cell Dev Biol (2012) 1.41
Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol (2006) 1.39
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31
Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A (2013) 1.31
Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29
Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int (2010) 1.27
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat Med (2014) 1.22
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A. Cancer Cell (2011) 1.22
Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol (2012) 1.22
Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis. J Clin Pathol (2005) 1.15
WNTS and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci (2007) 1.11
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest (2010) 1.08
Signaling circuitries controlling stem cell fate: to be or not to be. Curr Opin Cell Biol (2011) 1.06
Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency. Int J Biochem Cell Biol (2007) 1.02
Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol (2013) 1.02
Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis. Dev Dyn (2010) 1.00
Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development. Dev Biol (2007) 1.00
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC. Development (2007) 0.99
Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling. Am J Pathol (2004) 0.98
Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study. J Theor Biol (2010) 0.98
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of beta-catenin. J Cell Sci (2009) 0.98
Wnt5a as an effector of TGFβ in mammary development and cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
Cyclic expression of lhx2 regulates hair formation. PLoS Genet (2010) 0.95
The potential role of endogenous stem cells in regeneration of the inner ear. Hear Res (2007) 0.95
Wnt signaling in breast organogenesis. Organogenesis (2008) 0.94
Hairless is a nuclear receptor corepressor essential for skin function. Nucl Recept Signal (2009) 0.93
Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics (2004) 0.93
Mouse models of estrogen receptor-positive breast cancer. J Carcinog (2011) 0.91
Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling. Cell Commun Signal (2005) 0.90
Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Mol Cell Biol (2007) 0.89
Differential expression of a BMP4 reporter allele in anterior fungiform versus posterior circumvallate taste buds of mice. BMC Neurosci (2010) 0.87
Transcriptional profiling of putative human epithelial stem cells. BMC Genomics (2008) 0.87
Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging. Stem Cells Int (2016) 0.86
Regulation of trachebronchial tissue-specific stem cell pool size. Stem Cells (2013) 0.86
The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes. Mol Endocrinol (2014) 0.83
Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis. PLoS One (2013) 0.83
Development of anticancer agents targeting the Wnt/β-catenin signaling. Am J Cancer Res (2015) 0.83
Nothing but skin and bone. J Clin Invest (2006) 0.82
Investigating tonic Wnt signaling throughout the adult CNS and in the hippocampal neurogenic niche of BatGal and ins-TopGal mice. Cell Mol Neurobiol (2012) 0.82
The effects of aging on the expression of Wnt pathway genes in mouse tissues. Age (Dordr) (2014) 0.81
Distinct transcriptional networks in quiescent myoblasts: a role for Wnt signaling in reversible vs. irreversible arrest. PLoS One (2013) 0.81
The role of the Wnt signaling pathway in cancer stem cells: prospects for drug development. Res Rep Biochem (2014) 0.80
De Novo Transcriptome Assembly and Differential Gene Expression Profiling of Three Capra hircus Skin Types during Anagen of the Hair Growth Cycle. Int J Genomics (2013) 0.79
Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. PLoS Genet (2014) 0.79
Rho GTPases in embryonic development. Small GTPases (2014) 0.79
Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling. PLoS One (2012) 0.79
Wnt signaling induces epithelial differentiation during cutaneous wound healing. Organogenesis (2015) 0.78
Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy. Biomed Res Int (2015) 0.77
Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. FASEB J (2016) 0.77
Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling. PLoS One (2015) 0.76
Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicol Appl Pharmacol (2013) 0.76
Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling. Evid Based Complement Alternat Med (2016) 0.76
An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia. Medicine (Baltimore) (2016) 0.75
Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure. Sci Rep (2016) 0.75
Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer (2009) 0.75
Modelling western dietary habits in the mouse: easier said than done. Hepatobiliary Surg Nutr (2017) 0.75
Role of Wnt5a in the differentiation of human embryonic stem cells into endometrium-like cells. Int J Clin Exp Pathol (2015) 0.75
Evaluation of oral keratinocyte progenitor and T-lymphocite cells response during early healing after augmentation of keratinized gingiva with a 3D collagen matrix - a pilot study. BMC Oral Health (2016) 0.75
MAD2B acts as a negative regulatory partner of TCF4 on proliferation in human dermal papilla cells. Sci Rep (2017) 0.75
The Co-Expression Pattern of p63 and HDAC1: A Potential Way to Disclose Stem Cells in Interfollicular Epidermis. Int J Mol Sci (2017) 0.75
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30
A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51
A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40
Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02
Sticky business: orchestrating cellular signals at adherens junctions. Cell (2003) 4.91
Links between signal transduction, transcription and adhesion in epithelial bud development. Nature (2003) 4.88
Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
Dynamics between stem cells, niche, and progeny in the hair follicle. Cell (2011) 4.14
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev Cell (2002) 4.01
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79
Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat Cell Biol (2003) 3.77
Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol (2004) 3.70
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67
Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature (2011) 3.64
Interferon-γ links ultraviolet radiation to melanomagenesis in mice. Nature (2011) 3.56
Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell (2007) 3.55
Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51
A role for skin gammadelta T cells in wound repair. Science (2002) 3.51
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16
In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol (2003) 3.08
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol (2008) 3.07
GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev (2003) 2.97
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell (2008) 2.94
Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell (2011) 2.80
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79
Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat Rev Mol Cell Biol (2004) 2.79
Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
Catenins: keeping cells from getting their signals crossed. Dev Cell (2006) 2.70
Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (2002) 2.69
p120-catenin mediates inflammatory responses in the skin. Cell (2006) 2.66
ACF7: an essential integrator of microtubule dynamics. Cell (2003) 2.66
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol Cell (2012) 2.66
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev (2011) 2.63
The hair cycle. J Cell Sci (2006) 2.58
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
RNAi screens in mice identify physiological regulators of oncogenic growth. Nature (2013) 2.46
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41
Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell (2011) 2.36
Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell (2012) 2.35
Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26
Stem cells of the skin epithelium. Proc Natl Acad Sci U S A (2003) 2.20
Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. J Cell Biol (2007) 2.16
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 2.14
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A (2011) 2.08
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07
Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility. J Clin Invest (2009) 2.06
Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med (2010) 2.01
Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell (2012) 1.99
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99
A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91
A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell (2011) 1.83
Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A (2006) 1.77
Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell (2009) 1.77
Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. Dev Cell (2013) 1.70
A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol (2004) 1.63
Isolation and culture of epithelial stem cells. Methods Mol Biol (2009) 1.63
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development (2010) 1.55
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science (2014) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47
Structure and transcription of the human m3 muscarinic receptor gene. Am J Respir Cell Mol Biol (2002) 1.47
Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci (2006) 1.42
Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A (2008) 1.40
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol (2006) 1.38
Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol (2011) 1.37
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A (2008) 1.37
A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev Cell (2003) 1.35
SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev (2014) 1.34
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol (2006) 1.33
Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment. Cell Stem Cell (2011) 1.33
AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol (2008) 1.33
What does the concept of the stem cell niche really mean today? BMC Biol (2012) 1.32
p63: revving up epithelial stem-cell potential. Nat Cell Biol (2007) 1.32
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature (2013) 1.29
Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat Cell Biol (2011) 1.28
The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A (2002) 1.27
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A (2013) 1.26
Mice cloned from skin cells. Proc Natl Acad Sci U S A (2007) 1.23
Coordinating cytoskeletal tracks to polarize cellular movements. J Cell Biol (2004) 1.20
Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol (2005) 1.20
MicroRNAs and their roles in mammalian stem cells. J Cell Sci (2011) 1.19
A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells. J Cell Biol (2002) 1.19
Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction. Development (2012) 1.17
Spectraplakins: master orchestrators of cytoskeletal dynamics. J Cell Biol (2012) 1.16
Nfatc1 orchestrates aging in hair follicle stem cells. Proc Natl Acad Sci U S A (2013) 1.14