Published in Nat Rev Neurosci on August 01, 2007
Molecular and cellular approaches for diversifying and extending optogenetics. Cell (2010) 8.43
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci (2010) 8.09
Highly selective receptive fields in mouse visual cortex. J Neurosci (2008) 6.43
High-throughput ethomics in large groups of Drosophila. Nat Methods (2009) 5.30
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci (2012) 4.87
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69
Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34
A disinhibitory microcircuit for associative fear learning in the auditory cortex. Nature (2011) 4.12
Neural syntax: cell assemblies, synapsembles, and readers. Neuron (2010) 3.75
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Circuits controlling vertebrate locomotion: moving in a new direction. Nat Rev Neurosci (2009) 3.58
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Motor control in a Drosophila taste circuit. Neuron (2009) 3.48
Basal forebrain activation enhances cortical coding of natural scenes. Nat Neurosci (2009) 3.21
Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature (2010) 3.13
What does the amygdala contribute to social cognition? Ann N Y Acad Sci (2010) 3.11
Rapid neocortical dynamics: cellular and network mechanisms. Neuron (2009) 3.06
The microbial opsin family of optogenetic tools. Cell (2011) 2.94
Electrophysiology in the age of light. Nature (2009) 2.90
Advances in light microscopy for neuroscience. Annu Rev Neurosci (2009) 2.88
Remote control of neuronal signaling. Pharmacol Rev (2011) 2.66
Designing customized cell signalling circuits. Nat Rev Mol Cell Biol (2010) 2.64
Measured motion: searching for simplicity in spinal locomotor networks. Curr Opin Neurobiol (2009) 2.40
Interneuron cell types are fit to function. Nature (2014) 2.34
Amygdala interneuron subtypes control fear learning through disinhibition. Nature (2014) 2.29
Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A (2009) 2.24
Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell (2012) 2.22
Balanced amplification: a new mechanism of selective amplification of neural activity patterns. Neuron (2009) 2.17
Multi-array silicon probes with integrated optical fibers: light-assisted perturbation and recording of local neural circuits in the behaving animal. Eur J Neurosci (2010) 2.17
Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci U S A (2008) 2.13
Automated light-based mapping of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice. Nat Methods (2009) 2.13
Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol (2008) 2.12
The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12
Cortical enlightenment: are attentional gamma oscillations driven by ING or PING? Neuron (2009) 2.10
Targeted electrode-based modulation of neural circuits for depression. J Clin Invest (2009) 2.03
Diverse visual features encoded in mouse lateral geniculate nucleus. J Neurosci (2013) 1.95
Experience-dependent modification of a central amygdala fear circuit. Nat Neurosci (2013) 1.88
Intracortical multiplication of thalamocortical signals in mouse auditory cortex. Nat Neurosci (2013) 1.84
Neuronal arithmetic. Nat Rev Neurosci (2010) 1.77
Prefrontal D1 dopamine signaling is required for temporal control. Proc Natl Acad Sci U S A (2012) 1.74
AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future. Neuron (2010) 1.68
Light-induced rescue of breathing after spinal cord injury. J Neurosci (2008) 1.68
What can mice tell us about how vision works? Trends Neurosci (2011) 1.65
Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion. Nat Neurosci (2010) 1.63
Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J Neurosci (2009) 1.58
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory. Neurosci Biobehav Rev (2010) 1.57
Neural circuits: Putting neurons on the map. Nature (2009) 1.53
Visual receptive field properties of neurons in the superficial superior colliculus of the mouse. J Neurosci (2010) 1.53
A new chamber for studying the behavior of Drosophila. PLoS One (2010) 1.49
Placing prediction into the fear circuit. Trends Neurosci (2011) 1.47
Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle. Biophys J (2010) 1.46
The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans. Nat Commun (2011) 1.45
Orderly recruitment of motor units under optical control in vivo. Nat Med (2010) 1.43
Linear transformation of thalamocortical input by intracortical excitation. Nat Neurosci (2013) 1.40
Optogenetic control of cells and circuits. Annu Rev Cell Dev Biol (2011) 1.40
Synapses and memory storage. Cold Spring Harb Perspect Biol (2012) 1.39
Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. Front Neural Circuits (2009) 1.39
In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice. J Physiol (2011) 1.38
Excitatory neuronal connectivity in the barrel cortex. Front Neuroanat (2012) 1.37
Rapid optical control of nociception with an ion-channel photoswitch. Nat Methods (2012) 1.33
Ion channels in microbes. Physiol Rev (2008) 1.33
Future developments in brain-machine interface research. Clinics (Sao Paulo) (2011) 1.33
Optogenetic disruption of sleep continuity impairs memory consolidation. Proc Natl Acad Sci U S A (2011) 1.32
Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics. Nat Neurosci (2011) 1.31
Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci U S A (2014) 1.30
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci (2010) 1.25
Understanding synapses: past, present, and future. Neuron (2008) 1.25
The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Res (2009) 1.25
Cardiac optogenetics. Am J Physiol Heart Circ Physiol (2013) 1.24
Courtship learning in Drosophila melanogaster: diverse plasticity of a reproductive behavior. Learn Mem (2009) 1.19
Genetic and optical targeting of neural circuits and behavior--zebrafish in the spotlight. Curr Opin Neurobiol (2009) 1.19
Targeted single-cell electroporation of mammalian neurons in vivo. Nat Protoc (2009) 1.16
Optical neural interfaces. Annu Rev Biomed Eng (2014) 1.15
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR. Proc Natl Acad Sci U S A (2009) 1.13
Closed-loop optogenetic intervention in mice. Nat Protoc (2013) 1.12
Visual tuning properties of genetically identified layer 2/3 neuronal types in the primary visual cortex of cre-transgenic mice. Front Syst Neurosci (2011) 1.12
Toward a neural basis for social behavior. Neuron (2013) 1.11
In-depth activation of channelrhodopsin 2-sensitized excitable cells with high spatial resolution using two-photon excitation with a near-infrared laser microbeam. Biophys J (2008) 1.10
Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron. J Neurophysiol (2012) 1.09
Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats. J Neurosci (2013) 1.09
Limb-state information encoded by peripheral and central somatosensory neurons: implications for an afferent interface. IEEE Trans Neural Syst Rehabil Eng (2011) 1.08
Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory. J Neurosci (2013) 1.06
Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. Int Rev Neurobiol (2010) 1.05
Optogenetics, sex, and violence in the brain: implications for psychiatry. Biol Psychiatry (2011) 1.04
Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PLoS One (2014) 1.04
Photosensory functions of channelrhodopsins in native algal cells. Photochem Photobiol (2009) 1.03
Closed-loop, open-source electrophysiology. Front Neurosci (2010) 1.03
SU-8 force sensing pillar arrays for biological measurements. Lab Chip (2009) 1.03
Controlling the elements: an optogenetic approach to understanding the neural circuits of fear. Biol Psychiatry (2011) 1.03
Virtual active touch using randomly patterned intracortical microstimulation. IEEE Trans Neural Syst Rehabil Eng (2011) 1.03
Cholinergic circuit modulation through differential recruitment of neocortical interneuron types during behaviour. J Physiol (2014) 1.01
Tracking stem cell differentiation in the setting of automated optogenetic stimulation. Stem Cells (2011) 1.01
Light scattering properties vary across different regions of the adult mouse brain. PLoS One (2013) 1.00
Movement, technology and discovery in the zebrafish. Curr Opin Neurobiol (2010) 1.00
Photons and neurons. Hear Res (2014) 0.98
Large-scale recording of neurons by movable silicon probes in behaving rodents. J Vis Exp (2012) 0.98
Optophysiological analysis of associational circuits in the olfactory cortex. Front Neural Circuits (2012) 0.97
Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. PLoS One (2012) 0.97
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79
Structural and molecular interrogation of intact biological systems. Nature (2013) 8.95
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25
Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature (2007) 8.22
Optical deconstruction of parkinsonian neural circuitry. Science (2009) 7.80
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Optogenetics in neural systems. Neuron (2011) 7.56
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature (2010) 7.35
The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48
Channelrhodopsin-2 and optical control of excitable cells. Nat Methods (2006) 5.46
Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature (2011) 5.41
Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012) 5.32
Astrocytes control breathing through pH-dependent release of ATP. Science (2010) 4.88
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Bi-stable neural state switches. Nat Neurosci (2008) 4.69
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69
Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci (2008) 4.52
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34
Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods (2011) 4.27
Temporally precise in vivo control of intracellular signalling. Nature (2009) 4.14
Dynamics of retrieval strategies for remote memories. Cell (2011) 4.04
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron (2004) 3.61
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med (2012) 3.53
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49
Transgenic mice with a reduced core body temperature have an increased life span. Science (2006) 3.37
Neuroscience. The brain activity map. Science (2013) 3.36
Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron (2012) 3.33
Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27
Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26
CLARITY for mapping the nervous system. Nat Methods (2013) 3.20
Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (2010) 3.15
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci (2012) 3.13
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A (2005) 3.05
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature (2012) 2.98
An optogenetic toolbox designed for primates. Nat Neurosci (2011) 2.95
The microbial opsin family of optogenetic tools. Cell (2011) 2.94
GABA neurons of the VTA drive conditioned place aversion. Neuron (2012) 2.86
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83
Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73
Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol (2008) 2.69
A causal link between prediction errors, dopamine neurons and learning. Nat Neurosci (2013) 2.68
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A (2011) 2.67
Frequency-dependent kinetics and prevalence of kiss-and-run and reuse at hippocampal synapses studied with novel quenching methods. Neuron (2006) 2.65
Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature (2013) 2.55
Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci (2010) 2.53
Structure-guided transformation of channelrhodopsin into a light-activated chloride channel. Science (2014) 2.50
The hypocretins: setting the arousal threshold. Nat Rev Neurosci (2002) 2.42
Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci (2011) 2.37
Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A (2009) 2.24
Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nat Neurosci (2011) 2.21
Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron (2013) 2.15
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci (2004) 2.13
Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol (2008) 2.12
Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc Natl Acad Sci U S A (2010) 1.88
GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. Nat Neurosci (2011) 1.85
Leptin regulates the reward value of nutrient. Nat Neurosci (2011) 1.83
Challenges and opportunities for next-generation intracortically based neural prostheses. IEEE Trans Biomed Eng (2011) 1.78
Prefrontal D1 dopamine signaling is required for temporal control. Proc Natl Acad Sci U S A (2012) 1.74
A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron (2013) 1.66
A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci (2011) 1.66
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat Methods (2012) 1.65
Optogenetic inhibition of cocaine seeking in rats. Addict Biol (2012) 1.64
Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J Neurosci (2009) 1.58
Two-photon optogenetics of dendritic spines and neural circuits. Nat Methods (2012) 1.56
Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion. J Neurochem (2006) 1.55
Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J Neurosci (2011) 1.51
Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue. J Neural Eng (2009) 1.48
Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. J Neurosci (2010) 1.45
Orderly recruitment of motor units under optical control in vivo. Nat Med (2010) 1.43