Published in Nature on April 26, 2009
Molecular and cellular approaches for diversifying and extending optogenetics. Cell (2010) 8.43
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature (2010) 7.35
Neurophysiological and computational principles of cortical rhythms in cognition. Physiol Rev (2010) 5.24
Modulation of visual responses by behavioral state in mouse visual cortex. Neuron (2010) 4.84
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell (2011) 4.58
Mechanisms of gamma oscillations. Annu Rev Neurosci (2012) 4.58
How inhibition shapes cortical activity. Neuron (2011) 4.53
Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex. Neuron (2010) 4.42
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods (2011) 4.27
Shaping functional architecture by oscillatory alpha activity: gating by inhibition. Front Hum Neurosci (2010) 4.03
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Different origins of gamma rhythm and high-gamma activity in macaque visual cortex. PLoS Biol (2011) 3.92
Neural syntax: cell assemblies, synapsembles, and readers. Neuron (2010) 3.75
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
Cortical interneurons that specialize in disinhibitory control. Nature (2013) 3.56
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Spectral fingerprints of large-scale neuronal interactions. Nat Rev Neurosci (2012) 3.44
Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol (2010) 3.38
Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli. Neuron (2012) 3.36
Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci (2011) 3.17
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell (2012) 3.16
Control of sleep and wakefulness. Physiol Rev (2012) 3.06
The θ-γ neural code. Neuron (2013) 2.69
Remote control of neuronal signaling. Pharmacol Rev (2011) 2.66
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Natural neural projection dynamics underlying social behavior. Cell (2014) 2.54
Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature (2010) 2.51
Differences in gamma frequencies across visual cortex restrict their possible use in computation. Neuron (2010) 2.47
Neural synchrony in cortical networks: history, concept and current status. Front Integr Neurosci (2009) 2.42
On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. Nat Commun (2013) 2.39
Interneuron cell types are fit to function. Nature (2014) 2.34
New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits. Neuron (2011) 2.28
From maps to mechanisms through neuroimaging of schizophrenia. Nature (2010) 2.28
Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nat Neurosci (2011) 2.21
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol Psychiatry (2011) 2.20
Multi-array silicon probes with integrated optical fibers: light-assisted perturbation and recording of local neural circuits in the behaving animal. Eur J Neurosci (2010) 2.17
The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophr Res (2015) 2.14
Transient slow gamma synchrony underlies hippocampal memory replay. Neuron (2012) 2.11
Cortical enlightenment: are attentional gamma oscillations driven by ING or PING? Neuron (2009) 2.10
Development and plasticity of the primary visual cortex. Neuron (2012) 2.07
Two-photon single-cell optogenetic control of neuronal activity by sculpted light. Proc Natl Acad Sci U S A (2010) 1.97
Dissecting local circuits: parvalbumin interneurons underlie broad feedback control of olfactory bulb output. Neuron (2013) 1.95
Distinct behavioural and network correlates of two interneuron types in prefrontal cortex. Nature (2013) 1.91
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell (2011) 1.89
Alterations of cortical GABA neurons and network oscillations in schizophrenia. Curr Psychiatry Rep (2010) 1.87
Optogenetics: 10 years of microbial opsins in neuroscience. Nat Neurosci (2015) 1.85
Genetically targeted magnetic control of the nervous system. Nat Neurosci (2016) 1.79
Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome. Proc Natl Acad Sci U S A (2012) 1.79
Challenges and opportunities for next-generation intracortically based neural prostheses. IEEE Trans Biomed Eng (2011) 1.78
Circuit dynamics of adaptive and maladaptive behaviour. Nature (2014) 1.75
Equalizing excitation-inhibition ratios across visual cortical neurons. Nature (2014) 1.71
Scaling brain size, keeping timing: evolutionary preservation of brain rhythms. Neuron (2013) 1.68
The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron (2009) 1.66
A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci (2011) 1.66
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat Methods (2012) 1.65
Targeting cells with single vectors using multiple-feature Boolean logic. Nat Methods (2014) 1.65
Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala. Neuron (2014) 1.64
Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion. Nat Neurosci (2010) 1.63
Parvalbumin-expressing interneurons linearly control olfactory bulb output. Neuron (2013) 1.59
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice. Nat Biotechnol (2014) 1.58
A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion. Nature (2015) 1.58
Validating γ oscillations and delayed auditory responses as translational biomarkers of autism. Biol Psychiatry (2010) 1.58
NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia. Schizophr Bull (2012) 1.57
Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia. Neuropharmacology (2011) 1.57
GABAergic interneuron origin of schizophrenia pathophysiology. Neuropharmacology (2011) 1.55
Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Science (2015) 1.53
Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clin Neurophysiol (2013) 1.52
In Vivo Measurement of GABA Transmission in Healthy Subjects and Schizophrenia Patients. Am J Psychiatry (2015) 1.51
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. Neural Plast (2011) 1.51
Revisiting the role of neurons in neurovascular coupling. Front Neuroenergetics (2010) 1.48
Single-trial speech suppression of auditory cortex activity in humans. J Neurosci (2010) 1.48
Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal. J Neurosci (2015) 1.47
Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc Natl Acad Sci U S A (2013) 1.45
Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding. Neuron (2015) 1.45
Local and long-range functional connectivity is reduced in concert in autism spectrum disorders. Proc Natl Acad Sci U S A (2013) 1.44
Recurrent network activity drives striatal synaptogenesis. Nature (2012) 1.44
Parallel input channels to mouse primary visual cortex. J Neurosci (2010) 1.43
The development of neural synchrony and large-scale cortical networks during adolescence: relevance for the pathophysiology of schizophrenia and neurodevelopmental hypothesis. Schizophr Bull (2011) 1.43
Closed-loop and activity-guided optogenetic control. Neuron (2015) 1.42
Control of basal ganglia output by direct and indirect pathway projection neurons. J Neurosci (2013) 1.41
Optogenetic control of cells and circuits. Annu Rev Cell Dev Biol (2011) 1.40
Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia. Am J Psychiatry (2012) 1.40
Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex. Nat Neurosci (2013) 1.39
Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques. Cell (2016) 1.39
Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome. Mol Autism (2017) 1.38
Opto-current-clamp actuation of cortical neurons using a strategically designed channelrhodopsin. PLoS One (2010) 1.38
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med (2015) 1.37
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci (2010) 1.36
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nat Rev Neurosci (2013) 1.35
Rapid target-specific remodeling of fast-spiking inhibitory circuits after loss of dopamine. Neuron (2011) 1.34
Stimulus selectivity and spatial coherence of gamma components of the local field potential. J Neurosci (2011) 1.33
Sarm1-mediated axon degeneration requires both SAM and TIR interactions. J Neurosci (2013) 1.32
Inhibition-induced theta resonance in cortical circuits. Neuron (2013) 1.31
Basket cell dichotomy in microcircuit function. J Physiol (2011) 1.30
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature (2007) 12.76
Modulation of oscillatory neuronal synchronization by selective visual attention. Science (2001) 12.03
Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci (2005) 11.68
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature (1995) 7.75
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Modulation of neuronal interactions through neuronal synchronization. Science (2007) 7.20
Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat Neurosci (2000) 6.86
Perception's shadow: long-distance synchronization of human brain activity. Nature (1999) 6.82
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc Natl Acad Sci U S A (2007) 5.42
Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. Science (2006) 4.39
Fast and slow contrast adaptation in retinal circuitry. Neuron (2002) 4.10
Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. Neuron (2007) 3.67
Sequential structure of neocortical spontaneous activity in vivo. Proc Natl Acad Sci U S A (2006) 3.54
Integrator or coincidence detector? The role of the cortical neuron revisited. Trends Neurosci (1996) 3.54
Interneuron Diversity series: Rhythm and mood in perisomatic inhibition. Trends Neurosci (2003) 3.45
Reproducibility and variability in neural spike trains. Science (1997) 3.39
Gamma oscillations correlate with working memory load in humans. Cereb Cortex (2003) 3.37
Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Nat Neurosci (2000) 3.17
Gating of human theta oscillations by a working memory task. J Neurosci (2001) 3.12
Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex. Cereb Cortex (2004) 2.56
In vivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons. J Neurosci (2002) 2.38
Intracellular correlates of hippocampal theta rhythm in identified pyramidal cells, granule cells, and basket cells. Hippocampus (1995) 2.24
Excess of high frequency electroencephalogram oscillations in boys with autism. Biol Psychiatry (2007) 2.15
Neurochemical features and synaptic connections of large physiologically-identified GABAergic cells in the rat frontal cortex. Neuroscience (1998) 2.07
Inter- and intra-laminar connections of pyramidal cells in the neocortex. Neurosci Res (2005) 1.59
The hierarchical development of monkey visual cortical regions as revealed by the maturation of parvalbumin-immunoreactive neurons. Brain Res Dev Brain Res (1996) 1.30
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Targeting DNA double-strand breaks with TAL effector nucleases. Genetics (2010) 14.49
Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy. N Engl J Med (2010) 13.57
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Structural and molecular interrogation of intact biological systems. Nature (2013) 8.95
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods (2010) 8.86
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25
Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature (2007) 8.22
Optical deconstruction of parkinsonian neural circuitry. Science (2009) 7.80
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Optogenetics in neural systems. Neuron (2011) 7.56
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature (2010) 7.35
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84
A transcription activator-like effector toolbox for genome engineering. Nat Protoc (2012) 6.81
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev Neurosci (2007) 5.91
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48
Channelrhodopsin-2 and optical control of excitable cells. Nat Methods (2006) 5.46
Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature (2011) 5.41
Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012) 5.32
Astrocytes control breathing through pH-dependent release of ATP. Science (2010) 4.88
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Bi-stable neural state switches. Nat Neurosci (2008) 4.69
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69
Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Mechanisms for human genomic rearrangements. Pathogenetics (2008) 4.54
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci (2008) 4.52
A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34
Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods (2011) 4.27
Temporally precise in vivo control of intracellular signalling. Nature (2009) 4.14
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Dynamics of retrieval strategies for remote memories. Cell (2011) 4.04
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92
Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol (2011) 3.88
Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA (2005) 3.83
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun (2012) 3.60
Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med (2012) 3.53
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res (2013) 3.51
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Neuroscience. The brain activity map. Science (2013) 3.36
Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron (2012) 3.33
Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27
Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26
Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol (2011) 3.24
CLARITY for mapping the nervous system. Nat Methods (2013) 3.20
Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (2010) 3.15
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci (2012) 3.13
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell (2011) 3.03
Biological applications of gold nanoparticles. Chem Soc Rev (2008) 3.01
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature (2012) 2.98
An optogenetic toolbox designed for primates. Nat Neurosci (2011) 2.95
The microbial opsin family of optogenetic tools. Cell (2011) 2.94
Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92
GABA neurons of the VTA drive conditioned place aversion. Neuron (2012) 2.86
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83