Published in Nature on March 09, 2011
Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012) 5.32
Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science (2013) 4.50
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods (2011) 4.27
Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol (2012) 4.04
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49
Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci (2014) 3.18
Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron (2012) 2.91
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits. Nat Protoc (2011) 2.90
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron (2013) 2.74
GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits. Neuron (2013) 2.43
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science (2013) 2.21
A circuit mechanism for differentiating positive and negative associations. Nature (2015) 2.19
Sweet and bitter taste in the brain of awake behaving animals. Nature (2015) 2.14
Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nat Med (2016) 2.12
Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci (2011) 2.12
Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals. Nat Neurosci (2014) 2.01
Fast modulation of visual perception by basal forebrain cholinergic neurons. Nat Neurosci (2013) 1.99
From circuits to behaviour in the amygdala. Nature (2015) 1.97
Neural and cellular mechanisms of fear and extinction memory formation. Neurosci Biobehav Rev (2012) 1.94
Optogenetics: 10 years of microbial opsins in neuroscience. Nat Neurosci (2015) 1.85
Seeking a spotless mind: extinction, deconsolidation, and erasure of fear memory. Neuron (2011) 1.80
Circuit dynamics of adaptive and maladaptive behaviour. Nature (2014) 1.75
The many paths to fear. Nat Rev Neurosci (2012) 1.72
Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nat Commun (2013) 1.70
Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain. PLoS One (2013) 1.70
BLA to vHPC inputs modulate anxiety-related behaviors. Neuron (2013) 1.65
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat Methods (2012) 1.65
CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. Neuron (2015) 1.64
Biophysical constraints of optogenetic inhibition at presynaptic terminals. Nat Neurosci (2016) 1.62
Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses. Cell (2015) 1.58
Collateral pathways from the ventromedial hypothalamus mediate defensive behaviors. Neuron (2015) 1.58
Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making. Nat Neurosci (2012) 1.57
Neural basis of emotional decision making in trait anxiety. J Neurosci (2013) 1.57
Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior. Neuron (2014) 1.55
A thalamic input to the nucleus accumbens mediates opiate dependence. Nature (2016) 1.49
Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal. J Neurosci (2015) 1.47
Genetically encoded optical indicators for the analysis of neuronal circuits. Nat Rev Neurosci (2012) 1.46
Hypothalamic survival circuits: blueprints for purposive behaviors. Neuron (2013) 1.45
Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields. Nat Neurosci (2014) 1.43
Closed-loop and activity-guided optogenetic control. Neuron (2015) 1.42
Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics. Nat Protoc (2013) 1.35
The neural signatures of distinct psychopathic traits. Soc Neurosci (2012) 1.35
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci (2014) 1.34
Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear. Proc Natl Acad Sci U S A (2012) 1.33
Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB. J Neurosci (2014) 1.28
50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov (2013) 1.28
A framework for studying emotions across species. Cell (2014) 1.27
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One (2012) 1.24
β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature (2014) 1.21
State-dependent architecture of thalamic reticular subnetworks. Cell (2014) 1.21
The participation of cortical amygdala in innate, odour-driven behaviour. Nature (2014) 1.18
Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats. Proc Natl Acad Sci U S A (2013) 1.16
Optical neural interfaces. Annu Rev Biomed Eng (2014) 1.15
Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLoS One (2011) 1.13
Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Biol Psychiatry (2013) 1.12
Dissecting local circuits in vivo: integrated optogenetic and electrophysiology approaches for exploring inhibitory regulation of cortical activity. J Physiol Paris (2011) 1.12
Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling. Cell Rep (2014) 1.11
Orexin, stress, and anxiety/panic states. Prog Brain Res (2012) 1.11
Basomedial amygdala mediates top-down control of anxiety and fear. Nature (2015) 1.11
The biology of fear. Curr Biol (2013) 1.10
Distributed circuits underlying anxiety. Front Behav Neurosci (2014) 1.10
Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit. Am J Psychiatry (2012) 1.09
Illuminating circuitry relevant to psychiatric disorders with optogenetics. Curr Opin Neurobiol (2014) 1.09
Optogenetic modulation of neural circuits that underlie reward seeking. Biol Psychiatry (2011) 1.09
Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats. J Neurosci (2013) 1.09
Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell (2014) 1.08
Modeling the Spatiotemporal Dynamics of Light and Heat Propagation for In Vivo Optogenetics. Cell Rep (2015) 1.07
Hypervigilance for fear after basolateral amygdala damage in humans. Transl Psychiatry (2012) 1.06
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. Brain Res (2012) 1.06
Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory. J Neurosci (2013) 1.06
The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides. Cold Spring Harb Perspect Med (2012) 1.04
Resolving the neural circuits of anxiety. Nat Neurosci (2015) 1.04
Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. Neurosci Biobehav Rev (2011) 1.04
Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Front Mol Neurosci (2013) 1.04
Glucocorticoid actions on synapses, circuits, and behavior: implications for the energetics of stress. Front Neuroendocrinol (2013) 1.03
Controlling the elements: an optogenetic approach to understanding the neural circuits of fear. Biol Psychiatry (2011) 1.03
Inhibition of fear by learned safety signals: a mini-symposium review. J Neurosci (2012) 1.03
The central amygdala as an integrative hub for anxiety and alcohol use disorders. Biol Psychiatry (2014) 1.02
Regulating anxiety with extrasynaptic inhibition. Nat Neurosci (2015) 1.01
Tools for resolving functional activity and connectivity within intact neural circuits. Curr Biol (2014) 1.00
Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res (2013) 1.00
Optogenetics. Proc Natl Acad Sci U S A (2013) 0.99
Insights into cortical oscillations arising from optogenetic studies. Biol Psychiatry (2012) 0.98
Optogenetic excitation of central amygdala amplifies and narrows incentive motivation to pursue one reward above another. J Neurosci (2014) 0.97
Optogenetics through windows on the brain in the nonhuman primate. J Neurophysiol (2013) 0.97
Thy1-expressing neurons in the basolateral amygdala may mediate fear inhibition. J Neurosci (2013) 0.97
Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J Neurosci (2015) 0.97
Inhibition to excitation ratio regulates visual system responses and behavior in vivo. J Neurophysiol (2011) 0.96
Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proc Natl Acad Sci U S A (2012) 0.96
Establishing causality for dopamine in neural function and behavior with optogenetics. Brain Res (2012) 0.96
Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval. Neuron (2016) 0.95
Optic ataxia: from Balint's syndrome to the parietal reach region. Neuron (2014) 0.95
Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. J Neurosci (2015) 0.94
Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses. Neuron (2014) 0.94
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Front Behav Neurosci (2014) 0.94
Following the genes: a framework for animal modeling of psychiatric disorders. BMC Biol (2011) 0.94
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors. Neuropsychopharmacology (2014) 0.93
Optogenetic dissection of amygdala functioning. Front Behav Neurosci (2014) 0.93
Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry (2005) 58.92
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Molecular and cellular approaches for diversifying and extending optogenetics. Cell (2010) 8.43
The emotional brain, fear, and the amygdala. Cell Mol Neurobiol (2003) 5.56
Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology (2010) 5.07
The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology (2010) 4.82
Stress, memory and the amygdala. Nat Rev Neurosci (2009) 4.57
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci (2007) 4.46
New vistas on amygdala networks in conditioned fear. J Neurophysiol (2004) 4.44
Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34
Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29
Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry (2009) 2.67
The role of the central nucleus of the amygdala in mediating fear and anxiety in the primate. J Neurosci (2004) 2.54
Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature (2008) 2.47
Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat. J Comp Neurol (1978) 2.39
Brain stress systems in the amygdala and addiction. Brain Res (2009) 2.14
Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav Brain Res (2002) 1.97
Behavioral changes associated with ablation of the amygdaloid complex in monkeys. J Comp Physiol Psychol (1956) 1.94
A description of the amygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections. J Comp Neurol (1978) 1.83
Benzodiazepines: use, abuse, and consequences. Pharmacol Rev (1992) 1.74
Intra-amygdaloid projections of the lateral nucleus in the cat: PHA-L anterograde labeling combined with postembedding GABA and glutamate immunocytochemistry. J Comp Neurol (1994) 1.46
Cytoarchitecture of the central amygdaloid nucleus of the rat. J Comp Neurol (1982) 1.41
Controlling the brain with light. Sci Am (2010) 1.35
Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior. Genes Brain Behav (2007) 1.11
The neuropsychology of anxiety: reprise. Nebr Symp Motiv (1996) 1.09
Immunocytochemical localization of glutamate decarboxylase in the rat basolateral amygdaloid nucleus, with special reference to GABAergic innervation of amygdalostriatal projection neurons. J Comp Neurol (1988) 1.08
Neuropeptide Y conjugated to saporin alters anxiety-like behavior when injected into the central nucleus of the amygdala or basomedial hypothalamus in BALB/cJ mice. Peptides (2010) 0.97
Anxiety disorders: clinical presentation and epidemiology. Handb Exp Pharmacol (2005) 0.96
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79
Structural and molecular interrogation of intact biological systems. Nature (2013) 8.95
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25
Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature (2007) 8.22
Optical deconstruction of parkinsonian neural circuitry. Science (2009) 7.80
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Optogenetics in neural systems. Neuron (2011) 7.56
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature (2010) 7.35
The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev Neurosci (2007) 5.91
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48
Channelrhodopsin-2 and optical control of excitable cells. Nat Methods (2006) 5.46
Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012) 5.32
Astrocytes control breathing through pH-dependent release of ATP. Science (2010) 4.88
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69
Bi-stable neural state switches. Nat Neurosci (2008) 4.69
Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci (2008) 4.52
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34
Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods (2011) 4.27
Temporally precise in vivo control of intracellular signalling. Nature (2009) 4.14
Dynamics of retrieval strategies for remote memories. Cell (2011) 4.04
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med (2012) 3.53
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49
Neuroscience. The brain activity map. Science (2013) 3.36
Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron (2012) 3.33
Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27
Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26
CLARITY for mapping the nervous system. Nat Methods (2013) 3.20
Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (2010) 3.15
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci (2012) 3.13
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature (2012) 2.98
An optogenetic toolbox designed for primates. Nat Neurosci (2011) 2.95
The microbial opsin family of optogenetic tools. Cell (2011) 2.94
GABA neurons of the VTA drive conditioned place aversion. Neuron (2012) 2.86
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79
Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73
Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol (2008) 2.69
A causal link between prediction errors, dopamine neurons and learning. Nat Neurosci (2013) 2.68
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A (2011) 2.67
Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature (2013) 2.55
Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci (2010) 2.53
Structure-guided transformation of channelrhodopsin into a light-activated chloride channel. Science (2014) 2.50
Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci (2011) 2.37
Ube3a is required for experience-dependent maturation of the neocortex. Nat Neurosci (2009) 2.28
Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A (2009) 2.24