Published in Nat Methods on December 18, 2011
Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science (2013) 4.50
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Independent optical excitation of distinct neural populations. Nat Methods (2014) 3.53
Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26
Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci (2014) 3.18
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nat Neurosci (2013) 2.98
Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron (2012) 2.91
Structure-guided transformation of channelrhodopsin into a light-activated chloride channel. Science (2014) 2.50
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat Methods (2014) 2.41
The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding. Science (2013) 2.22
Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors. Cell (2015) 1.84
Circuit dynamics of adaptive and maladaptive behaviour. Nature (2014) 1.75
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons. Nat Commun (2014) 1.75
Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors. Nat Commun (2014) 1.73
Targeting neurons and photons for optogenetics. Nat Neurosci (2013) 1.73
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat Methods (2012) 1.65
Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission. Nat Neurosci (2012) 1.64
Biophysical constraints of optogenetic inhibition at presynaptic terminals. Nat Neurosci (2016) 1.62
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose. Cell Metab (2016) 1.60
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice. Nat Biotechnol (2014) 1.58
Two-photon optogenetics of dendritic spines and neural circuits. Nat Methods (2012) 1.56
The paraventricular thalamus controls a central amygdala fear circuit. Nature (2015) 1.52
A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices. Lab Chip (2013) 1.52
Genetically encoded optical indicators for the analysis of neuronal circuits. Nat Rev Neurosci (2012) 1.46
Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice. Neuron (2016) 1.45
Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields. Nat Neurosci (2014) 1.43
Closed-loop and activity-guided optogenetic control. Neuron (2015) 1.42
Optogenetics in Mice Performing a Visual Discrimination Task: Measurement and Suppression of Retinal Activation and the Resulting Behavioral Artifact. PLoS One (2015) 1.39
Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice. Nat Methods (2015) 1.33
Engineering of bacterial phytochromes for near-infrared imaging, sensing, and light-control in mammals. Chem Soc Rev (2013) 1.31
An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol (2014) 1.30
Enhanced Archaerhodopsin Fluorescent Protein Voltage Indicators. PLoS One (2013) 1.27
Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model. PLoS Comput Biol (2013) 1.25
Cardiac optogenetics. Am J Physiol Heart Circ Physiol (2013) 1.24
Optogenetic control of targeted peripheral axons in freely moving animals. PLoS One (2013) 1.19
Characterization of a highly efficient blue-shifted channelrhodopsin from the marine alga Platymonas subcordiformis. J Biol Chem (2013) 1.19
Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. J Neurosci (2013) 1.16
Optical neural interfaces. Annu Rev Biomed Eng (2014) 1.15
Effects of climbing fiber driven inhibition on Purkinje neuron spiking. J Neurosci (2012) 1.15
Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics. Methods Mol Biol (2014) 1.14
High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device. Nat Protoc (2012) 1.14
Saccade modulation by optical and electrical stimulation in the macaque frontal eye field. J Neurosci (2013) 1.07
Modeling the Spatiotemporal Dynamics of Light and Heat Propagation for In Vivo Optogenetics. Cell Rep (2015) 1.07
Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue. Proc Natl Acad Sci U S A (2013) 1.06
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. Brain Res (2012) 1.06
Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine. Proc Natl Acad Sci U S A (2012) 1.06
Specific expression of channelrhodopsin-2 in single neurons of Caenorhabditis elegans. PLoS One (2012) 1.04
All-Optical Interrogation of Neural Circuits. J Neurosci (2015) 1.04
Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2. Elife (2014) 1.04
Targeting Neural Circuits. Cell (2016) 1.03
Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS One (2012) 1.02
Recent advances in optogenetics and pharmacogenetics. Brain Res (2013) 1.02
Optogenetic dissection of medial prefrontal cortex circuitry. Front Syst Neurosci (2014) 1.01
A magnetic rotary optical fiber connector for optogenetic experiments in freely moving animals. J Neurosci Methods (2014) 1.00
Tools for resolving functional activity and connectivity within intact neural circuits. Curr Biol (2014) 1.00
Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res (2013) 1.00
Two-photon excitation in scattering media by spatiotemporally shaped beams and their application in optogenetic stimulation. Biomed Opt Express (2013) 0.98
Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proc Natl Acad Sci U S A (2015) 0.97
Optogenetic control of cardiomyocytes via viral delivery. Methods Mol Biol (2014) 0.97
Cholinergic inputs from Basal forebrain add an excitatory bias to odor coding in the olfactory bulb. J Neurosci (2014) 0.96
Cardiac applications of optogenetics. Prog Biophys Mol Biol (2014) 0.95
Defining inhibitory neurone function in respiratory circuits: opportunities with optogenetics? J Physiol (2014) 0.95
OPTOGENETICS. Expanding the optogenetics toolkit. Science (2015) 0.94
Frequency-selective control of cortical and subcortical networks by central thalamus. Elife (2015) 0.93
In vivo optogenetic control of striatal and thalamic neurons in non-human primates. PLoS One (2012) 0.92
Optogenetic micro-electrocorticography for modulating and localizing cerebral cortex activity. J Neural Eng (2014) 0.92
Optogenetic Activation of Normalization in Alert Macaque Visual Cortex. Neuron (2015) 0.92
How might novel technologies such as optogenetics lead to better treatments in epilepsy? Adv Exp Med Biol (2014) 0.91
Optogenetic interrogations of the neural circuits underlying addiction. Curr Opin Neurobiol (2013) 0.91
Optogenetics enlightens neuroscience drug discovery. Nat Rev Drug Discov (2015) 0.90
Ion selectivity and competition in channelrhodopsins. Biophys J (2013) 0.89
Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. Neuron (2015) 0.89
A chemist and biologist talk to each other about caged neurotransmitters. Beilstein J Org Chem (2013) 0.88
Optical control of neuronal excitation and inhibition using a single opsin protein, ChR2. Sci Rep (2013) 0.88
rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo. PLoS One (2013) 0.88
A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices. J Neurosci (2016) 0.88
What optogenetic stimulation is telling us (and failing to tell us) about fast neurotransmitters and neuromodulators in brain circuits for wake-sleep regulation. Curr Opin Neurobiol (2014) 0.87
Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations. Neuroimage (2014) 0.87
Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study. J Physiol (2016) 0.87
Flash memory: photochemical imprinting of neuronal action potentials onto a microbial rhodopsin. J Am Chem Soc (2014) 0.87
When the electricity (and the lights) go out: transient changes in excitability. Nat Neurosci (2012) 0.87
State-dependent control of breathing by the retrotrapezoid nucleus. J Physiol (2015) 0.87
Integration of optogenetics with complementary methodologies in systems neuroscience. Nat Rev Neurosci (2017) 0.86
Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci (2014) 0.86
High-brightness organic light-emitting diodes for optogenetic control of Drosophila locomotor behaviour. Sci Rep (2016) 0.86
Imaging GFP-based reporters in neurons with multiwavelength optogenetic control. Biophys J (2014) 0.86
Dissecting inhibitory brain circuits with genetically-targeted technologies. Front Neural Circuits (2014) 0.85
Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex. J Neurosci (2015) 0.85
Optogenetic acidification of synaptic vesicles and lysosomes. Nat Neurosci (2015) 0.85
Programmable wireless light-emitting diode stimulator for chronic stimulation of optogenetic molecules in freely moving mice. Neurophotonics (2014) 0.85
Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics. J Neural Eng (2015) 0.85
Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis. J Neurosci (2015) 0.85
Algal photoreceptors: in vivo functions and potential applications. Planta (2013) 0.85
Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex. Front Synaptic Neurosci (2014) 0.85
ChR2 mutants at L132 and T159 with improved operational light sensitivity for vision restoration. PLoS One (2014) 0.85
Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Chem Biol (2015) 0.84
Optogenetic feedback control of neural activity. Elife (2015) 0.84
Delivery of continuously-varying stimuli using channelrhodopsin-2. Front Neural Circuits (2013) 0.84
Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins. PLoS One (2015) 0.84
Regulation of zebrafish sleep and arousal states: current and prospective approaches. Front Neural Circuits (2013) 0.84
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A (2003) 15.17
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Molecular and cellular approaches for diversifying and extending optogenetics. Cell (2010) 8.43
High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature (2010) 8.37
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25
Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Curr Biol (2005) 8.01
Optogenetics in neural systems. Neuron (2011) 7.56
A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J Neurosci (2008) 6.95
Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat Neurosci (2000) 6.86
The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84
Optogenetics. Nat Methods (2010) 6.49
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. PLoS One (2007) 5.98
Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin. Proc Natl Acad Sci U S A (2005) 5.95
Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron (2006) 5.65
Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature (2011) 5.41
An expanded palette of genetically encoded Ca²⁺ indicators. Science (2011) 5.05
Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys J (2009) 4.75
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Bi-stable neural state switches. Nat Neurosci (2008) 4.69
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci (2008) 4.52
Dynamics of retrieval strategies for remote memories. Cell (2011) 4.04
Kinetic evaluation of photosensitivity in genetically engineered neurons expressing green algae light-gated channels. Neurosci Res (2005) 3.85
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Single-cell optogenetic excitation drives homeostatic synaptic depression. Neuron (2010) 3.15
Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (2010) 3.15
Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function. J Mol Biol (2007) 2.88
A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Front Syst Neurosci (2011) 2.72
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A (2011) 2.67
Ultra light-sensitive and fast neuronal activation with the Ca²+-permeable channelrhodopsin CatCh. Nat Neurosci (2011) 2.37
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron (2011) 2.14
A user's guide to channelrhodopsin variants: features, limitations and future developments. Exp Physiol (2010) 1.84
Molecular determinants differentiating photocurrent properties of two channelrhodopsins from chlamydomonas. J Biol Chem (2008) 1.83
Network synchrony in the nucleus accumbens in vivo. J Neurosci (2001) 1.46
New channelrhodopsin with a red-shifted spectrum and rapid kinetics from Mesostigma viride. MBio (2011) 1.40
Opto-current-clamp actuation of cortical neurons using a strategically designed channelrhodopsin. PLoS One (2010) 1.38
Controlling the brain with light. Sci Am (2010) 1.35
Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses. Science (1982) 1.30
Effects on capacitance by overexpression of membrane proteins. Biochem Biophys Res Commun (2008) 1.22
Evolution of the channelrhodopsin photocycle model. Chemphyschem (2010) 1.17
Photocurrent attenuation by a single polar-to-nonpolar point mutation of channelrhodopsin-2. Photochem Photobiol Sci (2009) 1.16
Optogenetic analysis of synaptic transmission in the central nervous system of the nematode Caenorhabditis elegans. Nat Commun (2011) 1.11
Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. J Biol Chem (2010) 1.01
Spiking patterns of neocortical L5 pyramidal neurons in vitro change with temperature. Front Cell Neurosci (2011) 0.99
Voltage- and temperature-dependent gating of heterologously expressed channelrhodopsin-2. J Neurosci Methods (2010) 0.96
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79
Structural and molecular interrogation of intact biological systems. Nature (2013) 8.95
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25
Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature (2007) 8.22
Optical deconstruction of parkinsonian neural circuitry. Science (2009) 7.80
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Optogenetics in neural systems. Neuron (2011) 7.56
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature (2010) 7.35
The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev Neurosci (2007) 5.91
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48
Channelrhodopsin-2 and optical control of excitable cells. Nat Methods (2006) 5.46
Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature (2011) 5.41
Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012) 5.32
Astrocytes control breathing through pH-dependent release of ATP. Science (2010) 4.88
Ultrafast optogenetic control. Nat Neurosci (2010) 4.73
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69
Bi-stable neural state switches. Nat Neurosci (2008) 4.69
Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci (2008) 4.52
Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35
Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34
Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29
Temporally precise in vivo control of intracellular signalling. Nature (2009) 4.14
Dynamics of retrieval strategies for remote memories. Cell (2011) 4.04
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med (2012) 3.53
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49
Neuroscience. The brain activity map. Science (2013) 3.36
Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron (2012) 3.33
Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27
Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26
CLARITY for mapping the nervous system. Nat Methods (2013) 3.20
Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (2010) 3.15
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci (2012) 3.13
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature (2012) 2.98
An optogenetic toolbox designed for primates. Nat Neurosci (2011) 2.95
The microbial opsin family of optogenetic tools. Cell (2011) 2.94
GABA neurons of the VTA drive conditioned place aversion. Neuron (2012) 2.86
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79
Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73
Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol (2008) 2.69