A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy.

PubWeight™: 1.66‹?› | Rank: Top 3%

🔗 View Article (PMC 3308017)

Published in Nat Neurosci on August 21, 2011

Authors

Jeanne T Paz1, Astra S Bryant, Kathy Peng, Lief Fenno, Ofer Yizhar, Wayne N Frankel, Karl Deisseroth, John R Huguenard

Author Affiliations

1: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

Articles citing this

Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci (2012) 3.13

A corticothalamic switch: controlling the thalamus with dynamic synapses. Neuron (2015) 1.66

ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nat Neurosci (2014) 1.58

Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron (2017) 1.39

Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci (2015) 1.11

In vivo evaluation of the dentate gate theory in epilepsy. J Physiol (2015) 1.05

Optogenetics and epilepsy: past, present and future. Epilepsy Curr (2015) 1.04

Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice. J Neurosci (2012) 1.04

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell (2016) 1.02

Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS One (2012) 1.02

Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci (2015) 0.96

Optogenetically induced seizure and the longitudinal hippocampal network dynamics. PLoS One (2013) 0.96

Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy. Neurobiol Dis (2014) 0.95

Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome. J Biol Chem (2013) 0.90

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron (2015) 0.90

Cerebellar output controls generalized spike-and-wave discharge occurrence. Ann Neurol (2015) 0.88

Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development. J Neurosci (2015) 0.86

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice. Front Cell Neurosci (2013) 0.85

Effects of cortical feedback on the spatial properties of relay cells in the lateral geniculate nucleus. J Neurophysiol (2012) 0.85

Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy. Neurobiol Dis (2015) 0.82

Animal models of absence epilepsies: what do they model and do sex and sex hormones matter? Neurobiol Dis (2014) 0.82

Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy. PLoS Genet (2014) 0.81

Mechanisms underlying desynchronization of cholinergic-evoked thalamic network activity. J Neurosci (2014) 0.80

Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium. Epilepsy Curr (2013) 0.80

Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron (2016) 0.80

Control of absence seizures induced by the pathways connected to SRN in corticothalamic system. Cogn Neurodyn (2014) 0.79

Ionotropic glutamate receptor GluA4 and T-type calcium channel Cav 3.1 subunits control key aspects of synaptic transmission at the mouse L5B-POm giant synapse. Eur J Neurosci (2015) 0.79

Role of EphA/ephrin--a signaling in the development of topographic maps in mouse corticothalamic projections. J Comp Neurol (2013) 0.78

Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors. J Neurosci (2014) 0.78

Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat (2013) 0.78

Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder. J Psychiatry Neurosci (2012) 0.77

Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy. Neuroscientist (2015) 0.77

The Nucleus Reuniens of the Midline Thalamus Gates Prefrontal-Hippocampal Modulation of Ventral Tegmental Area Dopamine Neuron Activity. J Neurosci (2016) 0.77

Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome. Neurobiol Dis (2014) 0.77

T-type Ca2+ channels in absence epilepsy. Pflugers Arch (2014) 0.77

The role of T-type calcium channel genes in absence seizures. Front Neurol (2014) 0.77

Hidden in plain sight: spike-wave discharges in mouse inbred strains. Genes Brain Behav (2014) 0.77

SWDreader: a wavelet-based algorithm using spectral phase to characterize spike-wave morphological variation in genetic models of absence epilepsy. J Neurosci Methods (2014) 0.76

Attentional flexibility in the thalamus: now we're getting SOMwhere. Nat Neurosci (2015) 0.76

LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition. eNeuro (2016) 0.76

Two classes of excitatory synaptic responses in rat thalamic reticular neurons. J Neurophysiol (2016) 0.76

Spindle Activity Orchestrates Plasticity during Development and Sleep. Neural Plast (2016) 0.75

Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease. Neurobiol Aging (2016) 0.75

R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy. Epilepsy Curr (2012) 0.75

How deactivating an inhibitor causes absence epilepsy: validation of a noble lie. Epilepsy Curr (2013) 0.75

Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations. Neuron (2016) 0.75

From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease. Neuroscientist (2015) 0.75

NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy. Sci Rep (2017) 0.75

Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca(2+) Channels. Sleep (2016) 0.75

Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs. Sci Rep (2017) 0.75

Control of Absence Seizures by the Thalamic Feed-Forward Inhibition. Front Comput Neurosci (2017) 0.75

Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms. Cell Rep (2017) 0.75

Articles cited by this

Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A (2003) 15.17

Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79

Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci (2007) 7.65

Heterogeneity of release probability, facilitation, and depletion at central synapses. Neuron (1997) 6.30

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron (1995) 4.24

A family of AMPA-selective glutamate receptors. Science (1990) 3.85

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc Natl Acad Sci U S A (2004) 3.78

On the actions that one nerve cell can have on another: distinguishing "drivers" from "modulators". Proc Natl Acad Sci U S A (1998) 3.70

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61

Cellular mechanisms of a synchronized oscillation in the thalamus. Science (1993) 3.02

Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci (2002) 2.99

Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons. Neuron (2010) 2.79

Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J Comp Neurol (1992) 2.47

A molecular determinant for submillisecond desensitization in glutamate receptors. Science (1994) 2.43

Sleep, epilepsy and thalamic reticular inhibitory neurons. Trends Neurosci (2005) 2.36

Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci (1994) 2.07

Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J Neurophysiol (1998) 1.99

Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron (2009) 1.87

Corticothalamic projections from the cortical barrel field to the somatosensory thalamus in rats: a single-fibre study using biocytin as an anterograde tracer. Eur J Neurosci (1995) 1.84

Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. J Neurosci (2007) 1.77

Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J Neurosci (1995) 1.76

Differences in quantal amplitude reflect GluR4- subunit number at corticothalamic synapses on two populations of thalamic neurons. Proc Natl Acad Sci U S A (2001) 1.71

Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J Neurosci (2000) 1.69

Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. J Physiol (1995) 1.66

Organized growth of thalamocortical axons from the deep tier of terminations into layer IV of developing mouse barrel cortex. J Neurosci (1993) 1.59

Organization of the projections from barrel cortex to thalamus in mice studied with Phaseolus vulgaris-leucoagglutinin and HRP. Exp Brain Res (1987) 1.40

Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet (2008) 1.36

Corticothalamic interactions in the transfer of visual information. Philos Trans R Soc Lond B Biol Sci (2002) 1.35

Intracellular recordings in thalamic neurones during spontaneous spike and wave discharges in rats with absence epilepsy. J Physiol (1998) 1.32

The thalamic reticular nucleus of the adult rat: experimental anatomical studies. J Neurocytol (1985) 1.23

Cortical feedback controls the frequency and synchrony of oscillations in the visual thalamus. J Neurosci (2000) 1.21

Oscillatory synaptic interactions between ventroposterior and reticular neurons in mouse thalamus in vitro. J Neurophysiol (1994) 1.20

An electron microscopic study of the mode of termination of cortico-thalamic fibres within the sensory relay nuclei of the thalamus. Proc R Soc Lond B Biol Sci (1969) 1.18

Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus. Neuroscience (1999) 1.15

Predominance of corticothalamic synaptic inputs to thalamic reticular nucleus neurons in the rat. J Comp Neurol (1999) 1.14

Cellular interactions in the rat somatosensory thalamocortical system during normal and epileptic 5-9 Hz oscillations. J Physiol (2003) 1.13

Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. J Neurosci (2010) 1.11

Axonal trajectories between mouse somatosensory thalamus and cortex. J Comp Neurol (1987) 1.09

The axonal arborization of single thalamic reticular neurons in the somatosensory thalamus of the rat. Eur J Neurosci (1995) 1.09

Activity of ventral medial thalamic neurons during absence seizures and modulation of cortical paroxysms by the nigrothalamic pathway. J Neurosci (2007) 1.09

A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proc Natl Acad Sci U S A (2009) 1.05

Synaptic distribution of afferents from reticular nucleus in ventroposterior nucleus of cat thalamus. J Comp Neurol (1995) 1.05

Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle. J Neurophysiol (2009) 1.01

Differential synaptic distribution of AMPA receptor subunits in the ventral posterior and reticular thalamic nuclei of the rat. Neuroscience (2000) 0.99

Strong, reliable and precise synaptic connections between thalamic relay cells and neurones of the nucleus reticularis in juvenile rats. J Physiol (2003) 0.94

Endogenous perioxidatic activity in brain stem neurons as demonstrated by their staining with diaminobenzidine in normal squirrel monkeys. Brain Res (1976) 0.88

Corticothalamic networks, oscillations, and plasticity. Adv Neurol (1998) 0.84

Articles by these authors

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08

Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68

Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79

Structural and molecular interrogation of intact biological systems. Nature (2013) 8.95

Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76

Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature (2011) 8.25

Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature (2007) 8.22

Optical deconstruction of parkinsonian neural circuitry. Science (2009) 7.80

An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74

In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59

Optogenetics in neural systems. Neuron (2011) 7.56

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature (2010) 7.35

The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84

Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28

Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev Neurosci (2007) 5.91

Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48

Channelrhodopsin-2 and optical control of excitable cells. Nat Methods (2006) 5.46

Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature (2011) 5.41

Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012) 5.32

Astrocytes control breathing through pH-dependent release of ATP. Science (2010) 4.88

Ultrafast optogenetic control. Nat Neurosci (2010) 4.73

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc (2010) 4.69

Bi-stable neural state switches. Nat Neurosci (2008) 4.69

Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci (2008) 4.52

Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci (2012) 4.35

Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature (2010) 4.34

Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods (2011) 4.27

Temporally precise in vivo control of intracellular signalling. Nature (2009) 4.14

Dynamics of retrieval strategies for remote memories. Cell (2011) 4.04

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02

Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61

eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60

Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med (2012) 3.53

Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50

Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49

Neuroscience. The brain activity map. Science (2013) 3.36

Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron (2012) 3.33

The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30

Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27

Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26

CLARITY for mapping the nervous system. Nat Methods (2013) 3.20

Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (2010) 3.15

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci (2012) 3.13

High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13

A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature (2012) 2.98

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97

An optogenetic toolbox designed for primates. Nat Neurosci (2011) 2.95

The microbial opsin family of optogenetic tools. Cell (2011) 2.94

GABA neurons of the VTA drive conditioned place aversion. Neuron (2012) 2.86

Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84

Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83

Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73

Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol (2008) 2.69

A causal link between prediction errors, dopamine neurons and learning. Nat Neurosci (2013) 2.68

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A (2011) 2.67

Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature (2013) 2.55

Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci (2010) 2.53

Structure-guided transformation of channelrhodopsin into a light-activated chloride channel. Science (2014) 2.50

Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci (2011) 2.37

Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A (2009) 2.24

Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nat Neurosci (2011) 2.21

Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron (2013) 2.15

Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol (2008) 2.12

Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids. Nature (2004) 1.92

Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons. J Neurosci (2006) 1.90

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc Natl Acad Sci U S A (2010) 1.88

Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron (2009) 1.87

A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. J Neurosci (2002) 1.86

GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. Nat Neurosci (2011) 1.85

Leptin regulates the reward value of nutrient. Nat Neurosci (2011) 1.83

Challenges and opportunities for next-generation intracortically based neural prostheses. IEEE Trans Biomed Eng (2011) 1.78

Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats. J Neurosci (2006) 1.78

Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron (2006) 1.76

Gait analysis detects early changes in transgenic SOD1(G93A) mice. Muscle Nerve (2005) 1.75

Prefrontal D1 dopamine signaling is required for temporal control. Proc Natl Acad Sci U S A (2012) 1.74

Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J Neurophysiol (2005) 1.74