Published in PLoS One on April 03, 2013
The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet (2013) 2.89
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO. PLoS One (2014) 1.03
Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases. J Mol Biol (2013) 0.94
Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med (2015) 0.94
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation. Biochem J (2014) 0.90
Cullin 3 as a novel target in diverse pathologies. Redox Biol (2013) 0.89
Structural basis of Keap1 interactions with Nrf2. Free Radic Biol Med (2015) 0.88
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases. Am J Physiol Cell Physiol (2015) 0.87
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. Biochem J (2015) 0.85
KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination. Oncogene (2015) 0.84
A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter. Pflugers Arch (2015) 0.82
Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene. Biol Open (2015) 0.82
New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases. Biochem Soc Trans (2014) 0.82
Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). J Biol Chem (2014) 0.81
Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase. Genetics (2015) 0.76
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells. Mol Cell Biol (2016) 0.75
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. Arch Biochem Biophys (2016) 0.75
KLHL3 knockout mice reveal the physiological role of KLHL3 and the pathophysiology of PHAII caused by mutant KLHL3. Mol Cell Biol (2017) 0.75
Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population. Dis Markers (2017) 0.75
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Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol (2005) 14.42
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29
Molecular mechanisms of human hypertension. Cell (2001) 11.17
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell (2000) 7.82
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell (2008) 6.07
K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science (2011) 5.40
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat Cell Biol (2003) 5.18
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature (2006) 4.96
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature (2003) 4.79
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature (2012) 4.26
Sequence and structural analysis of BTB domain proteins. Genome Biol (2005) 3.88
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells (2011) 3.76
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A (2003) 3.48
Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev (2005) 3.46
BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol Cell (2003) 3.43
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol (2006) 3.22
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J (2004) 3.07
Ubiquitin-dependent regulation of COPII coat size and function. Nature (2012) 2.88
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell (2009) 2.84
Crystal structure of the BTB domain from PLZF. Proc Natl Acad Sci U S A (1998) 2.84
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell (2007) 2.69
Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci (2007) 2.57
Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail. Structure (2001) 2.48
The cullin protein family. Genome Biol (2011) 2.43
A fully automatic evolutionary classification of protein folds: Dali Domain Dictionary version 3. Nucleic Acids Res (2001) 2.32
A family of LIC vectors for high-throughput cloning and purification of proteins. Methods Mol Biol (2009) 2.30
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem Res Toxicol (2005) 2.22
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell (2011) 2.16
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet (2012) 1.93
Structural regulation of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2011) 1.89
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Brain (2010) 1.76
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci U S A (2010) 1.72
Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates. Structure (2010) 1.63
Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes. Curr Opin Cell Biol (2007) 1.61
Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway. J Neurosci (2010) 1.61
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. J Biol Chem (2013) 1.46
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. Cancer Cell (2011) 1.40
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. Structure (2012) 1.37
RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter. Am J Physiol Renal Physiol (2010) 1.20
Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol (2011) 1.17
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochem J (2009) 1.09
Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol (2010) 1.04
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. Protein Sci (2006) 1.01
Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene. Genomics (2000) 0.99
Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. J Biol Chem (2012) 0.92
ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experiments. Nucleic Acids Res (2009) 0.92
Rabex-5 protein regulates the endocytic trafficking pathway of ubiquitinated neural cell adhesion molecule L1. J Biol Chem (2012) 0.92
Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43. J Cell Sci (2012) 0.89
Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. J Mol Biol (2010) 0.86
KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation. Cell Signal (2010) 0.83
Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. Biochem Biophys Res Commun (2011) 0.79
Sequence and structural analysis of BTB domain proteins. Genome Biol (2005) 3.88
A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell (2010) 3.05
The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet (2013) 2.89
Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A (2002) 2.39
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell (2003) 2.20
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Brain (2010) 1.76
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin. EMBO J (2004) 1.60
Crystal structure of saposin B reveals a dimeric shell for lipid binding. Proc Natl Acad Sci U S A (2002) 1.58
Lipopeptide detergents designed for the structural study of membrane proteins. Nat Biotechnol (2003) 1.52
The BACK domain in BTB-kelch proteins. Trends Biochem Sci (2004) 1.48
Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell (2008) 1.46
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. Structure (2012) 1.37
Crystal structures of saposins A and C. Protein Sci (2006) 1.17
Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C. Proc Natl Acad Sci U S A (2007) 1.16
Gauging a hydrocarbon ruler by an intrinsic exciton probe. Biochemistry (2007) 1.14
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. Structure (2010) 1.09
Structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone Cnidopus japonicus. J Biol Chem (2006) 1.08
Insertion of carrier proteins into hydrophilic loops of the Escherichia coli lactose permease. Biochim Biophys Acta (2002) 1.04
Mechanisms of antimicrobial peptide action: studies of indolicidin assembly at model membrane interfaces by in situ atomic force microscopy. J Struct Biol (2006) 1.03
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. Protein Sci (2006) 1.01
Refolding SDS-denatured proteins by the addition of amphipathic cosolvents. J Mol Biol (2007) 0.95
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
Direct visualization of saposin remodelling of lipid bilayers. J Mol Biol (2006) 0.94
Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B. Protein Expr Purif (2003) 0.92
A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A. J Lipid Res (2005) 0.92
Stability of the lactose permease in detergent solutions. Biochim Biophys Acta (2002) 0.91
Structure of saposin A lipoprotein discs. Proc Natl Acad Sci U S A (2012) 0.88
Structures of the human ceramide activator protein saposin D. Acta Crystallogr D Biol Crystallogr (2008) 0.87
Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering. J Biomol Screen (2010) 0.87
Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. J Mol Biol (2010) 0.86
Protecting role of cosolvents in protein denaturation by SDS: a structural study. BMC Struct Biol (2008) 0.82
Crystal structure of a self-assembling lipopeptide detergent at 1.20 A. Proc Natl Acad Sci U S A (2008) 0.80
Molecular models of lipopeptide detergents: large coiled-coils with hydrocarbon interiors. J Am Chem Soc (2005) 0.79
Detergent-mediated protein aggregation. Chem Phys Lipids (2013) 0.76