Published in Mol Biol Cell on August 29, 2007
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi. Mol Biol Cell (2008) 1.43
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (2009) 1.35
Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma. World J Gastroenterol (2012) 1.16
Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility. Am J Hum Genet (2012) 0.99
Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients. PLoS One (2009) 0.96
Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am J Physiol Endocrinol Metab (2008) 0.94
Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin. Traffic (2014) 0.93
Distinct yet overlapping roles of Rab GTPases on synaptic vesicles. Small GTPases (2011) 0.93
Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils. J Biol Chem (2010) 0.93
Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors. J Leukoc Biol (2013) 0.91
Involvement of vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes. Traffic (2009) 0.91
Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis. Mol Cell Biol (2013) 0.88
Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion. J Biol Chem (2011) 0.87
Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. J Chem Neuroanat (2011) 0.86
Loss of Rab27 function results in abnormal lung epithelium structure in mice. Am J Physiol Cell Physiol (2010) 0.85
The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Mol Biol Cell (2012) 0.84
Rab GTPases, membrane trafficking and diseases. Curr Drug Targets (2011) 0.83
EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells. J Biol Chem (2013) 0.83
Two Rabs for exosome release. Nat Cell Biol (2010) 0.81
Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors. Dis Markers (2014) 0.81
A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells. PLoS One (2012) 0.81
Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site. PLoS One (2012) 0.80
Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts. PLoS One (2012) 0.79
Differential regulation of Rab GTPase expression in monocyte-derived dendritic cells upon lipopolysaccharide activation: a correlation to maturation-dependent functional properties. PLoS One (2013) 0.79
Role of Rab27 in synaptic transmission at the squid giant synapse. Proc Natl Acad Sci U S A (2008) 0.78
Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet (2015) 0.76
Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37. Sci Rep (2016) 0.76
Expression of Secretogranin III in Chicken Endocrine Cells: Its Relevance to the Secretory Granule Properties of Peptide Prohormone Processing and Bioactive Amine Content. J Histochem Cytochem (2015) 0.75
Long Noncoding RNA and mRNA Expression Profiles in the Thyroid Gland of Two Phenotypically Extreme Pig Breeds Using Ribo-Zero RNA Sequencing. Genes (Basel) (2016) 0.75
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling. Oncotarget (2017) 0.75
Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci U S A (2006) 6.83
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat Genet (2000) 5.11
A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Natl Acad Sci U S A (2000) 3.07
Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol (2001) 2.76
Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol (2001) 2.74
Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. J Biochem (2005) 2.22
Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J Cell Biol (2001) 1.95
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol (2002) 1.87
Rab27a: A key to melanosome transport in human melanocytes. J Cell Biol (2001) 1.86
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest (2005) 1.75
Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol (2005) 1.66
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron (1995) 1.57
The roles of Rab27 and its effectors in the regulated secretory pathways. Cell Struct Funct (2003) 1.52
Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker. Transgenic Res (1999) 1.33
The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J Cell Sci (2004) 1.30
Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology (2002) 1.30
Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochem Biophys Res Commun (2004) 1.29
Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc Natl Acad Sci U S A (2003) 1.20
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet (2001) 1.15
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
Further cytophysiologic evidence for the dentity of the cells that produce adrenocorticotrophic hormone. Endocrinology (1970) 1.08
Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Mol Biol Cell (2006) 0.99
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci (2007) 4.34
Innate versus learned odour processing in the mouse olfactory bulb. Nature (2007) 4.19
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol (2010) 2.98
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci (2006) 2.87
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest (2007) 2.45
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci (2002) 2.25
Transurethral incision of congenital obstructive lesions in the posterior urethra in boys and its effect on urinary incontinence and urodynamic study. BJU Int (2011) 2.25
Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell (2005) 2.21
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell (2003) 2.11
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron (2005) 2.11
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol (2002) 1.87
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell (2007) 1.82
Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion. Proc Natl Acad Sci U S A (2013) 1.82
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation (2004) 1.80
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest (2005) 1.75
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice. Hum Mol Genet (2002) 1.73
The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. J Immunol (2002) 1.71
Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol (2005) 1.66
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63
Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A (2007) 1.58
Syncope upon swallowing caused by an esophageal hiatal hernia compressing the left atrium: a case report. Echocardiography (2004) 1.55
High-efficiency CAG-FLPe deleter mice in C57BL/6J background. Exp Anim (2006) 1.53
A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem (2006) 1.52
Modular genetic control of sexually dimorphic behaviors. Cell (2012) 1.50
Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. FEBS Lett (2002) 1.50
GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci (2007) 1.41
Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J Neurosci (2007) 1.41
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. J Cell Biol (2007) 1.38
Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis (2004) 1.37
Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia. Circulation (2003) 1.35
Complementary expression and neurite outgrowth activity of netrin-G subfamily members. Mech Dev (2002) 1.35
Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient mice. Arterioscler Thromb Vasc Biol (2006) 1.35
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. J Biol Chem (2005) 1.34
Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. J Neurosci (2007) 1.33
Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a. Structure (2008) 1.33
Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet (2013) 1.32
Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology (2002) 1.30
Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochem Biophys Res Commun (2004) 1.29
Glial protein S100B modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci U S A (2002) 1.27
NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex. Mol Cell Neurosci (2002) 1.26
Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. J Biol Chem (2003) 1.26
Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents. Stroke (2006) 1.26
Docking is not a prerequisite but a temporal constraint for fusion of secretory granules. Traffic (2008) 1.26
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem (2005) 1.25
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiol Dis (2006) 1.23
Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. FEMS Immunol Med Microbiol (2002) 1.22
Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. Mol Cell Biol (2002) 1.22
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res (2007) 1.21
Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice. J Comp Neurol (2005) 1.21
Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc Natl Acad Sci U S A (2003) 1.20
A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol Psychiatry (2005) 1.20
Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem (2006) 1.19
Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice. Oncogene (2004) 1.19
Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. J Biol Chem (2004) 1.18
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice. Development (2004) 1.18
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. J Neurosci (2011) 1.17
Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice. Invest Ophthalmol Vis Sci (2003) 1.14
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PLoS One (2006) 1.14
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum Mol Genet (2004) 1.12
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. J Neurosci (2008) 1.11
Primary retroperitoneal mature cystic teratoma presenting as an adrenal tumor in an adult. Int J Urol (2010) 1.10
Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice. Front Behav Neurosci (2013) 1.10
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol (2007) 1.08
S100B is increased in Parkinson's disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway. Brain (2012) 1.07
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Hum Mol Genet (2009) 1.07
Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab (2006) 1.07
Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet (2006) 1.06
DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death. J Neurosci (2009) 1.04
Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules. J Comp Neurol (2004) 1.04
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J (2003) 1.04
Umbilical laparoendoscopic single-site technique for complete excision of urachal remnant. J Laparoendosc Adv Surg Tech A (2012) 1.02
Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice. J Neurochem (2007) 1.01
Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. J Neurosci (2008) 1.01
Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. J Biol Chem (2010) 1.01
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol (2013) 1.00
Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. J Biol Chem (2003) 1.00
Transgenic mice expressing a pH and Cl- sensing yellow-fluorescent protein under the control of a potassium channel promoter. Eur J Neurosci (2002) 0.99
Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Mol Biol Cell (2006) 0.99
Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system. Brain Res Dev Brain Res (2004) 0.98
Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory. J Neurosci (2008) 0.98
Cytoplasmic transport signal is involved in phogrin targeting and localization to secretory granules. Traffic (2005) 0.97
GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67. Biochem Biophys Res Commun (2008) 0.97
A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain. Biochem Biophys Res Commun (2003) 0.97
Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiency. Am J Transplant (2005) 0.97
Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release. J Neurochem (2007) 0.96
NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling. J Neurosci (2011) 0.96
Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses. Mol Brain (2013) 0.95
Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes. Eur J Neurosci (2007) 0.95
Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Genes Cells (2006) 0.95
Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions. Biochem Biophys Res Commun (2002) 0.95
Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia (2007) 0.95
Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function in excitatory cortical neurons. J Neurosci (2002) 0.94
Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol (2004) 0.94