Published in Science on July 23, 1965
N-formylmethionyl-sRNA as the initiator of protein synthesis. Proc Natl Acad Sci U S A (1966) 5.50
Super-suppressors in Saccharomyces cerevisiae. Genetics (1967) 2.99
Suppressor system in Bacillus subtilis 168. J Bacteriol (1969) 2.75
Translation of the genetic message, ii. Effect of initiation factors on the binding of formyl-methionyl-trna to ribosomes. Proc Natl Acad Sci U S A (1967) 2.73
Suppression of radiation sensitivity and capsular polysaccharide synthesis in Escherichia coli K-12 by ochre suppressors. J Bacteriol (1967) 2.57
Mechanism of protein biosynthesis. Bacteriol Rev (1969) 2.57
Induction of capsular polysaccharide synthesis by rho-fluorophenylalanine in Escherichia coli wild type and strains with altered phenylalanyl soluble ribonucleic acid synthetase. J Bacteriol (1967) 2.54
Recessive lethals: a new class of nonsense suppressors in Escherichia coli. Proc Natl Acad Sci U S A (1969) 2.53
Binding of adenosine 3':5'-cyclic phosphate to G factor of Escherichia coli, and its effects on GTPase, RNase V, and protein synthesis. Proc Natl Acad Sci U S A (1970) 2.49
In vitro studies on the mechanism of suppression of a nonsense mutation. Proc Natl Acad Sci U S A (1965) 2.28
Studies of missense suppression of the tryptophan synthetase A-protein mutant A36. Proc Natl Acad Sci U S A (1966) 1.97
Role of guanosine 5'-triphosphate in the initiation of Peptide synthesis, I. Synthesis of formylmethionyl-puromycin. Proc Natl Acad Sci U S A (1967) 1.87
Effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information. J Bacteriol (1966) 1.68
TRNA methylases in tumors of animal and human origin. Proc Natl Acad Sci U S A (1966) 1.63
Genetic mapping and dominance of the amber suppressor, Su1 (supD), in Escherichia coli K-12. J Bacteriol (1970) 1.57
Suppressor gene Su3+ of E. coli, a structural gene for tyrosine TRNA. Proc Natl Acad Sci U S A (1968) 1.57
The conversion of amber suppressors to ochre suppressors. Proc Natl Acad Sci U S A (1968) 1.55
Translation of the genome of a ribonucleic acid bacteriophage. Bacteriol Rev (1972) 1.40
The release of polypeptide chains from ribosomes in cell-free amino acid-incorporating systems by specific combinations of bases in synthetic polyribonucleotides. Proc Natl Acad Sci U S A (1965) 1.35
The reconstitution of infective bacteriophage R17. Proc Natl Acad Sci U S A (1967) 1.31
Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J Bacteriol (2004) 1.29
The initiation of viral protein synthesis in e. Coli extracts. Proc Natl Acad Sci U S A (1966) 1.28
Single-locus modification of position-effect variegation in Drosophila melanogaster. I. White variegation. Genetics (1967) 1.18
Effect of mutation to streptomycin resistance on amber suppressor genes. J Bacteriol (1968) 1.14
Derepression of alkaline phosphatase in Escherichia coli by p-fluorophenylalanine. J Bacteriol (1967) 1.13
Control of translation of MS2 RNA cistrons by MS2 coat protein. Proc Natl Acad Sci U S A (1967) 1.12
In vitro synthesis of T4 lysozyme by suppression of amber mutations. Proc Natl Acad Sci U S A (1967) 1.11
Escherichia coli supH suppressor: temperature-sensitive missense suppression caused by an anticodon change in tRNASer2. J Bacteriol (1985) 1.08
Missense suppression of the tryptophan synthetase A-protein mutant A78. Proc Natl Acad Sci U S A (1966) 1.08
Suppression of amber and ochre rII mutants of bacteriophage T4 by streptomycin. J Bacteriol (1966) 1.06
Isolation and characterization of lambda transducing bacteriophages for the su1+ (supD minus) amber suppressor of Escherichia coli. J Bacteriol (1975) 1.05
A nucleotide change in the anticodon of an Escherichia coli serine transfer RNA results in supD-amber suppression. Nucleic Acids Res (1983) 1.04
Mutations to spectinomycin resistance which alleviate the restriction of an amber suppressor by streptomycin resistance. J Bacteriol (1969) 1.00
The effect of ribonuclease on polysomes and ribosomes of bacteria and animal cells. Biochem J (1968) 0.96
Cell-free protein synthesis directed by Q beta-RNA and by two specific fragments. Proc Natl Acad Sci U S A (1968) 0.86
The molecular basis of suppression in an ochre suppressor strain possessing altered ribosomes. Proc Natl Acad Sci U S A (1969) 0.84
Expression of a DNA replication gene cluster in bacteriophage T4: genetic linkage and the control of gene product interactions. Genetics (1984) 0.80
Super suppressors in Neurospora crassa I. Induction, genetic localization and relationship to a missense suppressor. Genetics (1972) 0.79
Suppression of two missense alleles of the TRP5 locus of Saccharomyces cerevisiae. Genetics (1974) 0.79
Problems in protein biosynthesis. J Gen Physiol (1966) 0.78
Genetic analysis of a gene required for the expression of allele-specific missense suppression in Saccharomyces cerevisiae. Genetics (1971) 0.77
Suppressor-induced structural changes in a missense L-ribulokinase of Escherichia coli. J Bacteriol (1976) 0.75
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell (1980) 8.30
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49
High frequency targeting of genes to specific sites in the mammalian genome. Cell (1986) 6.91
N-formylmethionyl-sRNA as the initiator of protein synthesis. Proc Natl Acad Sci U S A (1966) 5.50
Regulation of nitrogen fixation genes. Annu Rev Genet (1986) 4.79
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature (1991) 4.60
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53
Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet (1997) 4.50
Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol Cell Biol (1992) 4.19
Initiation of E. coli proteins. Proc Natl Acad Sci U S A (1966) 4.07
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature (1990) 3.92
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
The new mouse genetics: altering the genome by gene targeting. Trends Genet (1989) 3.53
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature (1986) 3.30
Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol Cell Biol (1985) 3.00
Characterization of three proteins involved in polypeptide chain termination. Cold Spring Harb Symp Quant Biol (1969) 2.84
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature (1992) 2.82
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A (2000) 2.71
A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest (1995) 2.48
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest (1996) 2.47
Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature (1995) 2.40
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development (1993) 2.39
Maintenance of functional equivalence during paralogous Hox gene evolution. Nature (2000) 2.24
Altered enzymes in drug-resistant variants of mammalian tissue culture cells. Proc Natl Acad Sci U S A (1973) 2.24
Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins. J Mol Biol (1966) 2.18
Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet (2000) 2.18
Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol (1997) 2.16
High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell Biol (1992) 2.14
Polypeptide chain termination in vitro: isolation of a release factor. Proc Natl Acad Sci U S A (1967) 2.08
The role of Hoxa-3 in mouse thymus and thyroid development. Development (1995) 1.93
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell (1975) 1.87
Hoxc13 mutant mice lack external hair. Genes Dev (1998) 1.84
Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev (1995) 1.80
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci U S A (1999) 1.77
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell (1982) 1.76
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development (1994) 1.73
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature (1994) 1.66
Selective degradation of abnormal proteins in mammalian tissue culture cells. Proc Natl Acad Sci U S A (1974) 1.66
Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol (1993) 1.64
A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. Development (1996) 1.60
Mutations affecting two different steps in transcription initiation at the phage lambda PRM promoter. Proc Natl Acad Sci U S A (1983) 1.58
Genetic characterization of a prm- mutant of bacteriophage lambda. Virology (1973) 1.54
The isolation of a suppressible nonsense mutant in mammalian cells. Cell (1977) 1.53
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development (1993) 1.49
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest (1997) 1.48
Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol (1997) 1.47
Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development (2001) 1.46
Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev (1994) 1.45
Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harb Symp Quant Biol (1984) 1.43
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev (1994) 1.41
Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev Biol (1998) 1.41
Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. Mol Cell Biol (1985) 1.37
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci U S A (1990) 1.36
DNA sequence analysis of prm-mutations of coliphage lambda. Gene (1980) 1.34
Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development (1993) 1.34
Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell (1991) 1.33
Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A (1997) 1.31
Normal limb development in conditional mutants of Fgf4. Development (2000) 1.31
Isolation and properties of rex - mutants of bacteriophage lambda. J Virol (1972) 1.30
Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol (1997) 1.28
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development (2000) 1.25
Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol (1975) 1.24
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development (1996) 1.23
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development (1999) 1.23
Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol (1996) 1.22
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development (1999) 1.16
Differential effects of mutations on discrete steps in transcription initiation at the lambda PRE promoter. Cell (1983) 1.16
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. Proc Natl Acad Sci U S A (1986) 1.15
Mutations in TrpI binding site II that differentially affect activation of the trpBA promoter of Pseudomonas aeruginosa. EMBO J (1991) 1.14
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science (1985) 1.12
Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays. Somat Cell Mol Genet (1986) 1.11
Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. EMBO J (1984) 1.11
Targeted gene replacement. Sci Am (1994) 1.10
RNA polymerases from Pseudomonas aeruginosa and Pseudomonas syringae respond to Escherichia coli activator proteins. J Bacteriol (1991) 1.10
Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development (1997) 1.08
Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. Mol Cell Biol (1987) 1.07
Interactions between Escherichia coli RNA polymerase and lambda repressor. Mutations in PRM affect repression of PR. J Mol Biol (1988) 1.07
Role of cII protein in stimulating transcription initiation at the lambda PRE promoter. Enhanced formation and stabilization of open complexes. J Mol Biol (1984) 1.06
The mouse Hoxc11 gene: genomic structure and expression pattern. Mech Dev (1998) 1.05
Polypetide chain termination. Purification of the release factors, R1 and R2, from Escherichia coli. J Biol Chem (1971) 1.05
Polarity in vitro. J Mol Biol (1967) 1.05
Kinetic analysis of mutations affecting the cII activation site at the PRE promoter of bacteriophage lambda. Proc Natl Acad Sci U S A (1984) 1.04
Activation of the trpBA promoter of Pseudomonas aeruginosa by TrpI protein in vitro. J Bacteriol (1991) 1.03
The rex gene of bacteriophage lambda is really two genes. Genetics (1982) 1.02
Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A (1998) 1.02
Effects of a single base-pair deletion in the bacteriophage lambda PRM promoter. Repression of PRM by repressor bound at OR2 and by RNA polymerase bound at PR. J Mol Biol (1993) 1.00
Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Mech Dev (1998) 0.99
Release factors mediating termination of complete proteins. Nature (1970) 0.98
Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol (2001) 0.98
Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. Development (1996) 0.98
Clustering of Prm- mutations of bacteriophage lambda in the region between 33 and 40 nucleotides from the cL transcription start point. Virology (1979) 0.98
Intact ribonucleic acid from defective particles of bacteriophage R17. J Mol Biol (1966) 0.96
Characterization of a doubly mutant derivative of the lambda PRM promoter. Effects of mutations on activation of PRM. J Mol Biol (1988) 0.94
Mutations that alter the DNA binding site for the bacteriophage lambda cII protein and affect the translation efficiency of the cII gene. J Mol Biol (1984) 0.93
Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. J Biol Chem (1975) 0.93
Direct and indirect effects of mutations in lambda PRM on open complex formation at the divergent PR promoter. J Mol Biol (1994) 0.92
Mouse genetics. YACs to the rescue. Nature (1993) 0.92
Nucleotide sequences of the trpI, trpB, and trpA genes of Pseudomonas syringae: positive control unique to fluorescent pseudomonads. Gene (1993) 0.91