Published in Mol Cell Biol on July 01, 1992
Ends-out, or replacement, gene targeting in Drosophila. Proc Natl Acad Sci U S A (2003) 5.55
Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol Cell Biol (1992) 4.19
Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol (1997) 2.23
Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy. Mol Cell Biol (1993) 2.12
The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells. EMBO J (2001) 2.07
P-element-induced interallelic gene conversion of insertions and deletions in Drosophila melanogaster. Mol Cell Biol (1993) 2.06
Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A (1995) 1.93
Hoxc13 mutant mice lack external hair. Genes Dev (1998) 1.84
DNA homology requirements for mitotic gap repair in Drosophila. Proc Natl Acad Sci U S A (1993) 1.66
Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol (1993) 1.64
Homology requirements for targeting heterologous sequences during P-induced gap repair in Drosophila melanogaster. Genetics (1997) 1.36
Targeting frequency for deletion vectors in embryonic stem cells. Mol Cell Biol (1994) 1.29
High-fidelity correction of mutations at multiple chromosomal positions by adeno-associated virus vectors. J Virol (1999) 1.24
Parameters determining the efficiency of gene targeting in the moss Physcomitrella patens. Nucleic Acids Res (2005) 1.21
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Homologous recombination is required for AAV-mediated gene targeting. Nucleic Acids Res (2006) 1.11
A mouse model of familial porphyria cutanea tarda. Proc Natl Acad Sci U S A (2001) 1.11
Parameters controlling the rate of gene targeting frequency in the protozoan parasite Leishmania. Nucleic Acids Res (1997) 1.09
Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci. Mol Cell Biol (1994) 1.03
Requirements for ectopic homologous recombination in mammalian somatic cells. Mol Cell Biol (1996) 0.95
Homology dependence of targeted recombination at the Chinese hamster APRT locus. Mol Cell Biol (1994) 0.91
Genetic stability of gene targeted immunoglobulin loci. I. Heavy chain isotype exchange induced by a universal gene replacement vector. Immunology (1996) 0.90
Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouse. Brain Res (2010) 0.90
Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer. J Virol (2001) 0.89
A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. Mamm Genome (2006) 0.86
Mechanisms involved in targeted gene replacement in mammalian cells. Genetics (2000) 0.84
X-inactivation analysis of embryonic lethality in Ocrl wt/-; Inpp5b-/- mice. Mamm Genome (2010) 0.83
Enhancement of gene targeting in human cells by intranuclear permeation of the Saccharomyces cerevisiae Rad52 protein. Nucleic Acids Res (2010) 0.82
Genetically modified mice-successes and failures of a widely used technology. Pflugers Arch (2010) 0.82
Cre recombinase mediated alterations of the mouse genome using embryonic stem cells. Methods Mol Biol (2008) 0.81
Gene-targeted embryonic stem cells: real-time PCR assay for estimation of the number of neomycin selection cassettes. Biol Proced Online (2011) 0.80
Testing predictions of the double-strand break repair model relating to crossing over in Mammalian cells. Genetics (2004) 0.79
Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. Genetics (2011) 0.79
Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein. Cardiol Res Pract (2012) 0.78
Nascent DNA synthesis during homologous recombination is synergistically promoted by the rad51 recombinase and DNA homology. Genetics (2014) 0.78
Screening of HaCaT clones for CCL20 gene knockout and preliminary exploration of gene-targeting vector transfection approaches in this cell line. Med Sci Monit Basic Res (2015) 0.77
In celebration of Dr. Mario R. Capecchi's Nobel Prize. Int J Biol Sci (2007) 0.75
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science (1990) 8.17
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature (1984) 6.54
Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc Natl Acad Sci U S A (1984) 6.48
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell (1991) 6.14
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature (1991) 5.98
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature (1991) 4.60
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature (1989) 4.46
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature (1990) 3.92
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell (1991) 3.53
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature (1986) 3.30
Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol Cell Biol (1991) 3.25
Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1988) 3.20
Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science (1989) 2.90
Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science (1991) 2.01
Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs. Proc Natl Acad Sci U S A (1989) 1.77
Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein. Proc Natl Acad Sci U S A (1990) 1.37
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci U S A (1990) 1.36
Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting. Proc Natl Acad Sci U S A (1989) 1.10
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell (1980) 8.30
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49
High frequency targeting of genes to specific sites in the mammalian genome. Cell (1986) 6.91
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58
N-formylmethionyl-sRNA as the initiator of protein synthesis. Proc Natl Acad Sci U S A (1966) 5.50
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature (1991) 4.60
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53
Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet (1997) 4.50
Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor. Science (1965) 4.34
Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol Cell Biol (1992) 4.19
Initiation of E. coli proteins. Proc Natl Acad Sci U S A (1966) 4.07
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature (1990) 3.92
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A (2000) 3.55
The new mouse genetics: altering the genome by gene targeting. Trends Genet (1989) 3.53
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature (1986) 3.30
Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol Cell Biol (1985) 3.00
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
Characterization of three proteins involved in polypeptide chain termination. Cold Spring Harb Symp Quant Biol (1969) 2.84
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature (1992) 2.82
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A (2000) 2.71
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A (1998) 2.51
A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest (1995) 2.48
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest (1996) 2.47
Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature (1995) 2.40
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development (1993) 2.39
The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules. J Cell Biol (1997) 2.33
Active anaphylaxis in IgE-deficient mice. Nature (1994) 2.32
Maintenance of functional equivalence during paralogous Hox gene evolution. Nature (2000) 2.24
Altered enzymes in drug-resistant variants of mammalian tissue culture cells. Proc Natl Acad Sci U S A (1973) 2.24
Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet (2000) 2.18
Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins. J Mol Biol (1966) 2.18
Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol (1997) 2.16
Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol Cell Biol (2000) 2.15
Polypeptide chain termination in vitro: isolation of a release factor. Proc Natl Acad Sci U S A (1967) 2.08
A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A (1999) 2.05
Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature (1997) 2.03
A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J Clin Invest (1999) 1.96
The role of Hoxa-3 in mouse thymus and thyroid development. Development (1995) 1.93
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 1.93
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell (1975) 1.87
Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem (2000) 1.86
Hoxc13 mutant mice lack external hair. Genes Dev (1998) 1.84
Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev (2000) 1.81
Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev (1995) 1.80
Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver. Oncogene (1998) 1.78
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci U S A (1999) 1.77
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell (1982) 1.76
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development (1994) 1.73
Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. Dev Biol (2001) 1.71
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature (1994) 1.66
Selective degradation of abnormal proteins in mammalian tissue culture cells. Proc Natl Acad Sci U S A (1974) 1.66
Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J Biol Chem (2000) 1.64
Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol (1993) 1.64
Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev (1995) 1.61
A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. Development (1996) 1.60
The isolation of a suppressible nonsense mutant in mammalian cells. Cell (1977) 1.53
Post-transplant lymphoproliferative disease in children. Pediatr Transplant (2001) 1.51
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development (1993) 1.49
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest (1997) 1.48
Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol (1997) 1.47
Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development (2001) 1.46
Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev (1994) 1.45
Vigorimeter grip strength in CIDP: a responsive tool that rapidly measures the effect of IVIG--the ICE study. Eur J Neurol (2012) 1.45
Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harb Symp Quant Biol (1984) 1.43
Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Proc Natl Acad Sci U S A (1999) 1.42
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev (1994) 1.41
Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev Biol (1998) 1.41
Exploring the role of CT densitometry: a randomised study of augmentation therapy in alpha1-antitrypsin deficiency. Eur Respir J (2009) 1.41
Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. Mol Cell Biol (1985) 1.37
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci U S A (1990) 1.36
Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development (1993) 1.34
Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell (1991) 1.33
Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A (1997) 1.31
Normal limb development in conditional mutants of Fgf4. Development (2000) 1.31
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. Oncogene (1995) 1.30
Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol (1997) 1.28
Animal models of myasthenia gravis. Clin Immunol (2000) 1.25
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development (2000) 1.25
Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms. Technol Cancer Res Treat (2003) 1.24
Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol (1975) 1.24
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development (1996) 1.23
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development (1999) 1.23
A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Hum Mol Genet (2001) 1.23
Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice. J Exp Med (1997) 1.22
Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol (1996) 1.22
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. Cancer Res (1999) 1.19
Mouse decay-accelerating factor: selective and tissue-specific induction by estrogen of the gene encoding the glycosylphosphatidylinositol-anchored form. J Immunol (1996) 1.17
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development (1999) 1.16
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. Proc Natl Acad Sci U S A (1986) 1.15
Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. J Clin Invest (2000) 1.15
Resistance to apoptosis in HIV-infected CD4+ T lymphocytes is mediated by macrophages: role for Nef and immune activation in viral persistence. J Immunol (2000) 1.14
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science (1985) 1.12
Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays. Somat Cell Mol Genet (1986) 1.11
Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. EMBO J (1984) 1.11