Polypeptide chain termination in vitro: isolation of a release factor.

Release factors differing in specificity for terminator codons. Proc Natl Acad Sci U S A (1968) 4.18

Insights into translational termination from the structure of RF2 bound to the ribosome. Science (2008) 3.89

Bacterial ribosome. Bacteriol Rev (1970) 2.88

Mechanism of protein biosynthesis. Bacteriol Rev (1969) 2.57

Identical 3'-terminal octanucleotide sequence in 18S ribosomal ribonucleic acid from different eukaryotes. A proposed role for this sequence in the recognition of terminator codons. Biochem J (1974) 2.52

Peptide chain termination. 3. Stimulation of in vitro termination. Proc Natl Acad Sci U S A (1969) 1.97

Small, smaller, smallest: the origins and evolution of ancient dual symbioses in a Phloem-feeding insect. Genome Biol Evol (2013) 1.93

Localization and characterization of the gene encoding release factor RF3 in Escherichia coli. Proc Natl Acad Sci U S A (1994) 1.82

Novel E. coli mutants deficient in biosynthesis of 5-methylaminomethyl-2-thiouridine. Nucleic Acids Res (1984) 1.76

Peptide chain termination. V. The role of release factors in mRNA terminator codon recognition. Proc Natl Acad Sci U S A (1969) 1.68

Enzymatic hydrolysis of N-substituted aminoacyl-tRNA. Proc Natl Acad Sci U S A (1967) 1.53

Translation of the genome of a ribonucleic acid bacteriophage. Bacteriol Rev (1972) 1.40

The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits. RNA (2005) 1.29

Recognition of the amber UAG stop codon by release factor RF1. EMBO J (2010) 1.23

Analysis of ribosomes from viomycin-sensitive and -resistant strains of Mycobacterium smegmatis. J Bacteriol (1972) 1.20

Release factor RF-3 GTPase activity acts in disassembly of the ribosome termination complex. RNA (1998) 1.19

Suppression of premature termination codons as a therapeutic approach. Crit Rev Biochem Mol Biol (2012) 1.13

Studies on the formation of trensfer ribonucleic acid-ribosome complexes. V. On the function of a soluble transfer factor in protein synthesis. Proc Natl Acad Sci U S A (1968) 1.13

Structural aspects of translation termination on the ribosome. RNA (2011) 1.11

On the specificity and stability of an enzyme that hydrolyzes N-substituted aminoacyl-transfer RNA's. Proc Natl Acad Sci U S A (1968) 1.10

A primary role for release factor 3 in quality control during translation elongation in Escherichia coli. Cell (2011) 1.01

Crystal structures of 70S ribosomes bound to release factors RF1, RF2 and RF3. Curr Opin Struct Biol (2012) 0.94

tmRNA is essential in Shigella flexneri. PLoS One (2013) 0.93

Structural basis for translation termination by archaeal RF1 and GTP-bound EF1α complex. Nucleic Acids Res (2012) 0.93

Lack of peptide-release activity responding to codon UGA in Mycoplasma capricolum. Nucleic Acids Res (1993) 0.93

Kinetics of stop codon recognition by release factor 1. Biochemistry (2009) 0.92

Unique protein moieties for 30S and 50S ribosomes of Escherichia coli. J Bacteriol (1969) 0.89

Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1. Nucleic Acids Res (2012) 0.88

Crystal structure of the 70S ribosome bound with the Q253P mutant form of release factor RF2. Structure (2013) 0.87

Reprogramming the genetic code. EMBO J (2011) 0.87

The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G). Nucleic Acids Res (2008) 0.87

Peptide release promoted by methylated RF2 and ArfA in nonstop translation is achieved by an induced-fit mechanism. RNA (2015) 0.83

Histidine 197 in release factor 1 is essential for a site binding and peptide release. Biochemistry (2010) 0.79

Release of tRNA from ribosomes by a factor other than G factor. Proc Natl Acad Sci U S A (1970) 0.78

Trans-translation is essential in the human pathogen Legionella pneumophila. Sci Rep (2016) 0.75

Polypeptide synthesis in Escherichia coli. II. The polypeptide chain and S-RNA. J Mol Biol (1963) 7.21

CO-LINEARITY OF THE GENE WITH THE POLYPEPTIDE CHAIN. Nature (1964) 7.01

A strong suppressor specific for UGA. Nature (1967) 3.73

Catalysis of peptide bond formation by 50 S ribosomal subunits from Escherichia coli. J Mol Biol (1967) 2.35

Studies on amber suppressor tRNA. Cold Spring Harb Symp Quant Biol (1966) 1.78

BINDING OF TRANSFER RIBONUCLEIC ACID TO RIBOSOMES ENGAGED IN PROTEIN SYNTHESIS: NUMBER AND PROPERTIES OF RIBOSOMAL BINDING SITES. J Mol Biol (1965) 1.54

Studies on the mechanism of polypeptide chain termination in cell-free extracts of E. coli. Proc Natl Acad Sci U S A (1966) 1.47

Polypeptide chain termination using synthetic polynucleotides. J Mol Biol (1965) 1.41

Punctuation in the genetic code. Cold Spring Harb Symp Quant Biol (1966) 1.15

Polypeptide chain termination in cell-free extracts of E. coli. Cold Spring Harb Symp Quant Biol (1966) 1.12

Translation of the genetic message, IV. UAA as a chain termination codon. Proc Natl Acad Sci U S A (1967) 0.99

Use of miniature transistor oscillators in dental research. Nature (1965) 0.90

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36

High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell (1980) 8.30

Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49

High frequency targeting of genes to specific sites in the mammalian genome. Cell (1986) 6.91

N-formylmethionyl-sRNA as the initiator of protein synthesis. Proc Natl Acad Sci U S A (1966) 5.50

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature (1991) 4.60

Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53

Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet (1997) 4.50

Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor. Science (1965) 4.34

Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol Cell Biol (1992) 4.19

Initiation of E. coli proteins. Proc Natl Acad Sci U S A (1966) 4.07

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature (1990) 3.92

Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59

The new mouse genetics: altering the genome by gene targeting. Trends Genet (1989) 3.53

Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature (1986) 3.30

Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol Cell Biol (1985) 3.00

Characterization of three proteins involved in polypeptide chain termination. Cold Spring Harb Symp Quant Biol (1969) 2.84

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature (1992) 2.82

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A (2000) 2.71

A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest (1995) 2.48

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest (1996) 2.47

Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature (1995) 2.40

Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development (1993) 2.39

Maintenance of functional equivalence during paralogous Hox gene evolution. Nature (2000) 2.24

Altered enzymes in drug-resistant variants of mammalian tissue culture cells. Proc Natl Acad Sci U S A (1973) 2.24

Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet (2000) 2.18

Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins. J Mol Biol (1966) 2.18

Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol (1997) 2.16

High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell Biol (1992) 2.14

The role of Hoxa-3 in mouse thymus and thyroid development. Development (1995) 1.93

Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell (1975) 1.87

Hoxc13 mutant mice lack external hair. Genes Dev (1998) 1.84

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev (1995) 1.80

Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci U S A (1999) 1.77

Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell (1982) 1.76

Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development (1994) 1.73

Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature (1994) 1.66

Selective degradation of abnormal proteins in mammalian tissue culture cells. Proc Natl Acad Sci U S A (1974) 1.66

Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol (1993) 1.64

A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. Development (1996) 1.60

The isolation of a suppressible nonsense mutant in mammalian cells. Cell (1977) 1.53

Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development (1993) 1.49

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest (1997) 1.48

Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol (1997) 1.47

Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development (2001) 1.46

Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev (1994) 1.45

Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harb Symp Quant Biol (1984) 1.43

Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev (1994) 1.41

Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev Biol (1998) 1.41

Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. Mol Cell Biol (1985) 1.37

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci U S A (1990) 1.36

Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development (1993) 1.34

Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell (1991) 1.33

Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A (1997) 1.31

Normal limb development in conditional mutants of Fgf4. Development (2000) 1.31

Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol (1997) 1.28

Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development (2000) 1.25

Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol (1975) 1.24

Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development (1996) 1.23

Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development (1999) 1.23

Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol (1996) 1.22

Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development (1999) 1.16

Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. Proc Natl Acad Sci U S A (1986) 1.15

Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science (1985) 1.12

Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays. Somat Cell Mol Genet (1986) 1.11

Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. EMBO J (1984) 1.11

Targeted gene replacement. Sci Am (1994) 1.10

Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development (1997) 1.08

Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. Mol Cell Biol (1987) 1.07

The mouse Hoxc11 gene: genomic structure and expression pattern. Mech Dev (1998) 1.05

Polarity in vitro. J Mol Biol (1967) 1.05

Polypetide chain termination. Purification of the release factors, R1 and R2, from Escherichia coli. J Biol Chem (1971) 1.05

Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A (1998) 1.02

Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Mech Dev (1998) 0.99

Release factors mediating termination of complete proteins. Nature (1970) 0.98

Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol (2001) 0.98

Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. Development (1996) 0.98

Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. J Biol Chem (1975) 0.93

Mouse genetics. YACs to the rescue. Nature (1993) 0.92

Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways. Development (2000) 0.88

Effect of cell cycle position on transformation by microinjection. Somat Cell Mol Genet (1985) 0.88

Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles. Mol Cell Biol (1999) 0.86

Protein synthesis directed by DNA phage messengers. Cold Spring Harb Symp Quant Biol (1966) 0.86

Fractionation of a suppressor sRNA. J Mol Biol (1966) 0.84

Targeting of genes to specific sites in the mammalian genome. Cold Spring Harb Symp Quant Biol (1986) 0.83

Recombinant DNA technique and sickle cell anemia research. Science (1997) 0.80

Hair defects in Hoxc13 mutant mice. J Investig Dermatol Symp Proc (1999) 0.80

A rapid assay for polypeptide chain termination. Biochem Biophys Res Commun (1967) 0.79

SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene (2012) 0.79

TAXI/UAS: A molecular switch to control expression of genes in vivo. Hum Gene Ther (1996) 0.78

Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences. Kaibogaku Zasshi (1999) 0.76

Lessons from angiotensin-converting enzyme-deficient mice. Curr Opin Nephrol Hypertens (1996) 0.75

Corticostriatal circuit defects in Hoxb8 mutant mice. Mol Psychiatry (2017) 0.75