Published in J Mol Biol on October 28, 1966
Translation of virus mRNA: synthesis of bacteriophage Q beta proteins in a cell-free extract from wheat embryo. J Virol (1973) 2.09
Rapid inhibition of polypeptide chain extension by streptomycin. Proc Natl Acad Sci U S A (1968) 1.87
Studies on the mode of action of diphtheria toxin. VII. Toxin-stimulated hydrolysis of nicotinamide adenine dinucleotide in mammalian cell extracts. J Exp Med (1969) 1.83
Identification and characterization of the in vitro synthesized gene products of bacteriophage M13. J Virol (1975) 1.75
Aurintricarboxylic acid: inhibitor of initiation of protein synthesis. Proc Natl Acad Sci U S A (1971) 1.71
Translation of the genome of a ribonucleic acid bacteriophage. Bacteriol Rev (1972) 1.40
Self-assembly of biological structures. Bacteriol Rev (1969) 1.35
Translation of the genetic message, iii. Formylmethionine as initiator of proteins programed by polycistronic messenger RNA. Proc Natl Acad Sci U S A (1967) 1.30
A mutant of Escherichia coli with temperature-sensitive streptomycin protein. Proc Natl Acad Sci U S A (1970) 1.20
Reinitiation of translation from the triplet next to the amber termination codon in the absence of ribosome-releasing factor. Proc Natl Acad Sci U S A (1981) 1.18
Control of translation of MS2 RNA cistrons by MS2 coat protein. Proc Natl Acad Sci U S A (1967) 1.12
In vitro synthesis of deoxynucleotide kinase programmed by bacteriophage "T4-RNA. Proc Natl Acad Sci U S A (1971) 1.11
In vitro synthesis of T4 lysozyme by suppression of amber mutations. Proc Natl Acad Sci U S A (1967) 1.11
Specific cleavage of bacteriophage R17 RNA by an endonuclease isolated from E. coli MRE-600. Proc Natl Acad Sci U S A (1968) 1.09
The chain growth rate of T4 lysozyme in vitro. Proc Natl Acad Sci U S A (1970) 1.05
Chemical identification of specific immunoglobulins as the product of a cell-free system from plasmocytoma tumors. Proc Natl Acad Sci U S A (1968) 1.01
The effect of ribonuclease on polysomes and ribosomes of bacteria and animal cells. Biochem J (1968) 0.96
DNA-directed synthesis in vitro of T4 phage-specific enzymes. Proc Natl Acad Sci U S A (1972) 0.95
Control of translation by the conformation of messenger RNA. Proc Natl Acad Sci U S A (1971) 0.95
Aurintricarboxylic acid, a preferential inhibitor of initiation of protein synthesis. J Bacteriol (1971) 0.94
Studies of newly synthesized ribosomal ribonucleic acid of Escherichia coli. Biochem J (1969) 0.91
Cell-free protein synthesis directed by Q beta-RNA and by two specific fragments. Proc Natl Acad Sci U S A (1968) 0.86
Effect of benzo[a]pyrene-diolepoxide on infectivity and in vitro translation of phage MS2 RNA. Proc Natl Acad Sci U S A (1979) 0.82
Effect of infection with ribonucleic acid bacteriophage R23 on the inducible synthesis of beta-galactosidase in Escherichia coli. J Virol (1968) 0.82
Isolation of 30S and 50S active ribosomal subunits of Bacillus subtilis, Marburg strain. J Bacteriol (1975) 0.82
Yeast protein synthesis. Preparation and analysis of a highly active cell-free system. Biochem J (1974) 0.79
Efficacy of translation in the rickettsia Coxiella burnetii. J Bacteriol (1981) 0.77
Properties of the ribonucleic acid bacteriophage ZIK-1 coat protein and its synthesis in an Escherichia coli cell-free system. Biochem J (1972) 0.75
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell (1980) 8.30
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49
High frequency targeting of genes to specific sites in the mammalian genome. Cell (1986) 6.91
N-formylmethionyl-sRNA as the initiator of protein synthesis. Proc Natl Acad Sci U S A (1966) 5.50
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature (1991) 4.60
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53
Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet (1997) 4.50
Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor. Science (1965) 4.34
Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol Cell Biol (1992) 4.19
Initiation of E. coli proteins. Proc Natl Acad Sci U S A (1966) 4.07
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature (1990) 3.92
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
The new mouse genetics: altering the genome by gene targeting. Trends Genet (1989) 3.53
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature (1986) 3.30
Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol Cell Biol (1985) 3.00
Characterization of three proteins involved in polypeptide chain termination. Cold Spring Harb Symp Quant Biol (1969) 2.84
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature (1992) 2.82
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A (2000) 2.71
A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest (1995) 2.48
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest (1996) 2.47
Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature (1995) 2.40
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development (1993) 2.39
Maintenance of functional equivalence during paralogous Hox gene evolution. Nature (2000) 2.24
Altered enzymes in drug-resistant variants of mammalian tissue culture cells. Proc Natl Acad Sci U S A (1973) 2.24
Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet (2000) 2.18
Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol (1997) 2.16
High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell Biol (1992) 2.14
Polypeptide chain termination in vitro: isolation of a release factor. Proc Natl Acad Sci U S A (1967) 2.08
The role of Hoxa-3 in mouse thymus and thyroid development. Development (1995) 1.93
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell (1975) 1.87
Hoxc13 mutant mice lack external hair. Genes Dev (1998) 1.84
Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev (1995) 1.80
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci U S A (1999) 1.77
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell (1982) 1.76
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development (1994) 1.73
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature (1994) 1.66
Selective degradation of abnormal proteins in mammalian tissue culture cells. Proc Natl Acad Sci U S A (1974) 1.66
Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol (1993) 1.64
A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. Development (1996) 1.60
The isolation of a suppressible nonsense mutant in mammalian cells. Cell (1977) 1.53
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development (1993) 1.49
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest (1997) 1.48
Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol (1997) 1.47
Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development (2001) 1.46
Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev (1994) 1.45
Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harb Symp Quant Biol (1984) 1.43
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev (1994) 1.41
Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev Biol (1998) 1.41
Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. Mol Cell Biol (1985) 1.37
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci U S A (1990) 1.36
Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development (1993) 1.34
Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell (1991) 1.33
Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A (1997) 1.31
Normal limb development in conditional mutants of Fgf4. Development (2000) 1.31
Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol (1997) 1.28
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development (2000) 1.25
Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol (1975) 1.24
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development (1996) 1.23
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development (1999) 1.23
Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol (1996) 1.22
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development (1999) 1.16
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. Proc Natl Acad Sci U S A (1986) 1.15
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science (1985) 1.12
Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays. Somat Cell Mol Genet (1986) 1.11
Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. EMBO J (1984) 1.11
Targeted gene replacement. Sci Am (1994) 1.10
Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development (1997) 1.08
Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. Mol Cell Biol (1987) 1.07
The mouse Hoxc11 gene: genomic structure and expression pattern. Mech Dev (1998) 1.05
Polarity in vitro. J Mol Biol (1967) 1.05
Polypetide chain termination. Purification of the release factors, R1 and R2, from Escherichia coli. J Biol Chem (1971) 1.05
Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A (1998) 1.02
Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Mech Dev (1998) 0.99
Release factors mediating termination of complete proteins. Nature (1970) 0.98
Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol (2001) 0.98
Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. Development (1996) 0.98
Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. J Biol Chem (1975) 0.93
Mouse genetics. YACs to the rescue. Nature (1993) 0.92
Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways. Development (2000) 0.88
Effect of cell cycle position on transformation by microinjection. Somat Cell Mol Genet (1985) 0.88
Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles. Mol Cell Biol (1999) 0.86
Protein synthesis directed by DNA phage messengers. Cold Spring Harb Symp Quant Biol (1966) 0.86
Fractionation of a suppressor sRNA. J Mol Biol (1966) 0.84
Targeting of genes to specific sites in the mammalian genome. Cold Spring Harb Symp Quant Biol (1986) 0.83
Recombinant DNA technique and sickle cell anemia research. Science (1997) 0.80
Hair defects in Hoxc13 mutant mice. J Investig Dermatol Symp Proc (1999) 0.80
A rapid assay for polypeptide chain termination. Biochem Biophys Res Commun (1967) 0.79
SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene (2012) 0.79
TAXI/UAS: A molecular switch to control expression of genes in vivo. Hum Gene Ther (1996) 0.78
Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences. Kaibogaku Zasshi (1999) 0.76
Lessons from angiotensin-converting enzyme-deficient mice. Curr Opin Nephrol Hypertens (1996) 0.75
Corticostriatal circuit defects in Hoxb8 mutant mice. Mol Psychiatry (2017) 0.75