Published in Mol Cell on March 17, 2006
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr Opin Cell Biol (2008) 3.18
Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet (2009) 2.90
Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes. Nucleic Acids Res (2008) 2.70
Condensins: universal organizers of chromosomes with diverse functions. Genes Dev (2012) 2.40
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev (2010) 2.12
Clearing the way for mitosis: is cohesin a target? Nat Rev Mol Cell Biol (2009) 1.88
Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem (2008) 1.52
Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A (2010) 1.41
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
Human DNA polymerase iota protects cells against oxidative stress. EMBO J (2008) 1.31
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. Nucleic Acids Res (2007) 1.30
Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Nucleic Acids Res (2010) 1.17
Genetic advances in glioma: susceptibility genes and networks. Curr Opin Genet Dev (2010) 1.14
Condensin II alleviates DNA damage and is essential for tolerance of boron overload stress in Arabidopsis. Plant Cell (2011) 1.09
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood (2009) 1.08
Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle (2014) 1.05
RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) (2012) 1.00
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency. Proc Natl Acad Sci U S A (2012) 0.99
Quantitative analysis of chromosome condensation in fission yeast. Mol Cell Biol (2012) 0.96
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis. J Mol Histol (2006) 0.96
Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. PLoS One (2007) 0.95
Condensin: crafting the chromosome landscape. Chromosoma (2013) 0.94
Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? Breast Cancer Res (2011) 0.94
Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer. Mol Cell Proteomics (2012) 0.93
Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank. Breast Cancer Res (2014) 0.92
Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways. PLoS One (2012) 0.91
Negative regulation of condensin I by CK2-mediated phosphorylation. EMBO J (2006) 0.91
Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity. J Biol Chem (2010) 0.89
Chromatin maintenance by a molecular motor protein. Nucleus (2011) 0.86
Condensin recruitment to chromatin is inhibited by Chk2 kinase in response to DNA damage. Cell Cycle (2016) 0.84
Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. Mol Cell Biol (2013) 0.82
Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I. Chromosoma (2013) 0.82
Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. PLoS One (2011) 0.82
Radiation microbeams as spatial and temporal probes of subcellular and tissue response. Mutat Res (2010) 0.81
Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants. Genetics (2014) 0.81
Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. PLoS One (2009) 0.80
X-ray repair cross complementing protein 1 in base excision repair. Int J Mol Sci (2012) 0.80
Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Cell Rep (2014) 0.80
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. Mol Biol Cell (2007) 0.80
Comparative transcriptome profiling of an SV40-transformed human fibroblast (MRC5CVI) and its untransformed counterpart (MRC-5) in response to UVB irradiation. PLoS One (2013) 0.78
Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res (2015) 0.77
The Smc5-Smc6 heterodimer associates with DNA through several independent binding domains. Sci Rep (2015) 0.77
Genome maintenance in the context of 4D chromatin condensation. Cell Mol Life Sci (2016) 0.77
Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development. Elife (2016) 0.77
DNA damage to a single chromosome end delays anaphase onset. J Biol Chem (2014) 0.77
Condensin suppresses recombination and regulates double-strand break processing at the repetitive ribosomal DNA array to ensure proper chromosome segregation during meiosis in budding yeast. Mol Biol Cell (2014) 0.77
Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells. PLoS One (2015) 0.76
PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting. Prz Menopauzalny (2017) 0.75
p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates. PLoS One (2016) 0.75
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol (2007) 6.83
The cellular geography of aurora kinases. Nat Rev Mol Cell Biol (2003) 6.40
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
The dynamic kinetochore-microtubule interface. J Cell Sci (2004) 4.07
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell (2012) 3.27
The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell (2010) 3.26
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet (2007) 3.08
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma (2004) 2.94
Chk1 is required for spindle checkpoint function. Dev Cell (2007) 2.90
Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet (2009) 2.90
Hemodynamic changes in arteriovenous malformations after radiosurgery: transcranial Doppler evaluation. World Neurosurg (2011) 2.68
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64
Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes. Dev Cell (2003) 2.62
Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature (2002) 2.61
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J (2004) 2.60
A chromatin remodelling complex that loads cohesin onto human chromosomes. Nature (2002) 2.53
Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell (2008) 2.50
Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci (2003) 2.48
TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Nature (2002) 2.48
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature (2006) 2.47
A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A (2010) 2.36
Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Cell (2003) 2.20
Trashing the genome: the role of nucleases during apoptosis. Nat Rev Mol Cell Biol (2005) 2.19
Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J (2010) 2.17
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol (2006) 2.16
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet (2009) 2.14
Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem (2002) 2.13
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev (2009) 1.96
Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα. J Cell Biol (2012) 1.94
CENP-I is essential for centromere function in vertebrate cells. Dev Cell (2002) 1.94
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J (2004) 1.89
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature (2011) 1.84
Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells. Nucleic Acids Res (2009) 1.83
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J (2002) 1.82
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82
Condensin regulates the stiffness of vertebrate centromeres. Mol Biol Cell (2009) 1.81
MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity. J Cell Biol (2002) 1.81
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell (2006) 1.71
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc Natl Acad Sci U S A (2004) 1.70
Condensin: Architect of mitotic chromosomes. Chromosome Res (2009) 1.67
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Proc Natl Acad Sci U S A (2003) 1.62
Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. J Biol Chem (2002) 1.61
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J Cell Sci (2002) 1.61
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton (2004) 1.59
Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array. EMBO J (2002) 1.58
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol (2008) 1.54
Neovascularization precedes occlusion in moyamoya disease: angiographic findings in 172 pediatric patients. Eur Neurol (2014) 1.54
HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. EMBO J (2002) 1.50
Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem (2003) 1.50
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines. J Biol Chem (2005) 1.50
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res (2007) 1.48
Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes. Proc Natl Acad Sci U S A (2005) 1.47
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res (2004) 1.44
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell (2011) 1.43
Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J (2012) 1.41
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
Angiographic characteristics of unruptured middle cerebral artery aneurysms predicting perforator injuries. Br J Neurosurg (2011) 1.41
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
Contrasting roles of condensin I and condensin II in mitotic chromosome formation. J Cell Sci (2012) 1.35
The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol (2012) 1.33
The tiger genome and comparative analysis with lion and snow leopard genomes. Nat Commun (2013) 1.32
Sgt1 is required for human kinetochore assembly. EMBO Rep (2004) 1.30
Chromosome engineering allows the efficient isolation of vertebrate neocentromeres. Dev Cell (2013) 1.30
Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res (2010) 1.29
Cohesin mediates chromatin interactions that regulate mammalian β-globin expression. J Biol Chem (2011) 1.29
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell (2006) 1.26
Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology. Expert Opin Drug Deliv (2014) 1.26
CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. J Cell Sci (2002) 1.25
INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol (2009) 1.23
The chromosomal passenger complex: one for all and all for one. Cell (2007) 1.22
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A (2011) 1.21
Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. Mol Cell Biol (2003) 1.21
RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate. J Cell Sci (2003) 1.20
Efficiency of de novo centromere formation in human artificial chromosomes. Genomics (2002) 1.19
Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier. Mol Biol Cell (2009) 1.19
HP1: heterochromatin binding proteins working the genome. Epigenetics (2010) 1.16