Published in EMBO J on September 13, 2007
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Regulation of Cdc42 GTPase activity in the formation of hyphae in Candida albicans. Mol Biol Cell (2006) 1.20
Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Mol Cell Biol (2002) 1.19
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Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics (2001) 1.08
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The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint. EMBO J (2002) 1.01
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Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation. Mol Biol Cell (2003) 0.97
Extracellular signal-regulated kinase 1 interacts with and phosphorylates CdGAP at an important regulatory site. Mol Cell Biol (2005) 0.90
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The genetic landscape of a cell. Science (2010) 16.52
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Exploring genetic interactions and networks with yeast. Nat Rev Genet (2007) 5.67
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
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Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal (2010) 2.95
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin. J Cell Biol (2002) 2.17
Respiratory rhythm generation during gasping depends on persistent sodium current. Nat Neurosci (2006) 2.15
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
Systematic exploration of synergistic drug pairs. Mol Syst Biol (2011) 1.89
Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro. J Neurophysiol (2002) 1.88
Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci (2009) 1.88
The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol Cell Proteomics (2007) 1.70
The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. Curr Biol (2012) 1.65
Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J Neurosci (2009) 1.63
An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet (2011) 1.62
Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J Neurosci (2010) 1.62
Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro. J Neurosci (2008) 1.57
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat Methods (2008) 1.56
Global map of SUMO function revealed by protein-protein interaction and genetic networks. Mol Cell (2009) 1.55
Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation. Prog Brain Res (2007) 1.54
HysTag--a novel proteomic quantification tool applied to differential display analysis of membrane proteins from distinct areas of mouse brain. Mol Cell Proteomics (2003) 1.52
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Glycoproteomic reactor for human plasma. J Proteome Res (2009) 1.49
Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2. J Mol Cell Biol (2011) 1.48
Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro. J Neurosci (2008) 1.48
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Proteomics (2007) 1.43
A novel proteomics approach for the discovery of chromatin-associated protein networks. Mol Cell Proteomics (2008) 1.42
DRYGIN: a database of quantitative genetic interaction networks in yeast. Nucleic Acids Res (2009) 1.41
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem (2002) 1.41
Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity. Mol Cell Biol (2008) 1.38
Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol (2010) 1.36
Multiple rhythmic states in a model of the respiratory central pattern generator. J Neurophysiol (2009) 1.35
Bringing order to protein disorder through comparative genomics and genetic interactions. Genome Biol (2011) 1.34
Proteomic analysis of ubiquitinated proteins from human MCF-7 breast cancer cells by immunoaffinity purification and mass spectrometry. J Proteome Res (2005) 1.34
Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp. Biophys J (2008) 1.33
Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell (2009) 1.24
Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast. Mol Cell (2004) 1.24
Putting genetic interactions in context through a global modular decomposition. Genome Res (2011) 1.24
Lipidomics era: accomplishments and challenges. Mass Spectrom Rev (2010) 1.20
Defining the budding yeast chromatin-associated interactome. Mol Syst Biol (2010) 1.19
Respiratory rhythm generation in vivo. Physiology (Bethesda) (2014) 1.18
Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network. Biophys J (2002) 1.16
Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia. J Lipid Res (2010) 1.15
Proteome-wide discovery of evolutionary conserved sequences in disordered regions. Sci Signal (2012) 1.15
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Mol Biol Cell (2010) 1.14
Late-expiratory activity: emergence and interactions with the respiratory CpG. J Neurophysiol (2010) 1.11
The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11
SGAtools: one-stop analysis and visualization of array-based genetic interaction screens. Nucleic Acids Res (2013) 1.10
Q&A: epistasis. J Biol (2009) 1.10
Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol Cell (2011) 1.09
Kinetic properties and functional dynamics of sodium channels during repetitive spiking in a slow pacemaker neuron. J Neurosci (2010) 1.09
Nonsynonymous mutations within APOB in human familial hypobetalipoproteinemia: evidence for feedback inhibition of lipogenesis and postendoplasmic reticulum degradation of apolipoprotein B. J Biol Chem (2009) 1.07
The biologically relevant targets and binding affinity requirements for the function of the yeast actin-binding protein 1 Src-homology 3 domain vary with genetic context. Genetics (2007) 1.05
Exploring the yeast acetylome using functional genomics. Cell (2012) 1.05
Computational models and emergent properties of respiratory neural networks. Compr Physiol (2012) 1.04
Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda) (2012) 1.02
Mapping protein-protein interactions by mass spectrometry. Curr Opin Biotechnol (2006) 1.02
Biomarker assay translation from discovery to clinical studies in cancer drug development: quantification of emerging protein biomarkers. Adv Cancer Res (2007) 1.00
Proteomics in 2005/2006: developments, applications and challenges. Anal Chem (2007) 0.99
Linking the kinome and phosphorylome--a comprehensive review of approaches to find kinase targets. Mol Biosyst (2008) 0.99
TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro. J Neurosci (2010) 0.99
Proteomics: from gel based to gel free. Anal Chem (2005) 0.99
Phenotypic activation to discover biological pathways and kinase substrates. Cell Cycle (2006) 0.99
Protein complexes are central in the yeast genetic landscape. PLoS Comput Biol (2011) 0.99
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. J Cell Biol (2013) 0.98
Rare cell proteomic reactor applied to stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics study of human embryonic stem cell differentiation. Mol Cell Proteomics (2010) 0.98
Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. PLoS Biol (2009) 0.98
Structural-functional properties of identified excitatory and inhibitory interneurons within pre-Botzinger complex respiratory microcircuits. J Neurosci (2013) 0.96
Interacting oscillations in neural control of breathing: modeling and qualitative analysis. J Comput Neurosci (2010) 0.96
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci U S A (2009) 0.96
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A quantitative literature-curated gold standard for kinase-substrate pairs. Genome Biol (2011) 0.95
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A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling. Stem Cells (2015) 0.94
A picture is worth a thousand words: genomics to phenomics in the yeast Saccharomyces cerevisiae. FEBS Lett (2009) 0.94
Analytical aspects of proteomics: 2009-2010. Anal Chem (2011) 0.93
From cells to peptides: "one-stop" integrated proteomic processing using amphipols. J Proteome Res (2013) 0.93
Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol. J Physiol (2013) 0.93
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Advancements in top-down proteomics. Anal Chem (2011) 0.92
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. J Proteome Res (2007) 0.91
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci (2008) 0.91
Recent developments in mass spectrometry-based quantitative phosphoproteomics. Biochem Cell Biol (2008) 0.91
Isolation of somatic Na+ currents by selective inactivation of axonal channels with a voltage prepulse. J Neurosci (2010) 0.90
Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Mol Biol Cell (2009) 0.90