Published in Chest on October 09, 2007
Non-Eosinophilic Neutrophilic Asthma (ANNE) | NCT03479138
Microbiome and Exacerbations in Neutrophilic Asthma (AsmaEx) | NCT04260282
Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review. J Thorac Dis (2014) 1.95
IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med (2010) 1.91
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med (2012) 1.75
Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol (2015) 1.70
Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol (2012) 1.45
Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma. J Clin Invest (2011) 1.27
Receptor for advanced glycation end products and its involvement in inflammatory diseases. Int J Inflam (2013) 1.22
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax (2010) 1.19
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One (2012) 1.07
Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation. BMC Pulm Med (2013) 0.99
Refractory asthma: mechanisms, targets, and therapy. Allergy (2014) 0.99
Asthma and chronic obstructive pulmonary disease. Curr Opin Allergy Clin Immunol (2009) 0.97
Apolipoprotein A-I attenuates ovalbumin-induced neutrophilic airway inflammation via a granulocyte colony-stimulating factor-dependent mechanism. Am J Respir Cell Mol Biol (2012) 0.96
Outcome of occupational asthma after removal from exposure: A follow-up study. Can Respir J (2010) 0.95
Nox enzymes in allergic airway inflammation. Biochim Biophys Acta (2011) 0.91
Lower airway disease in asthmatics with and without rhinitis. Lung (2008) 0.90
Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1. Clin Exp Allergy (2012) 0.89
Characterizing asthma from a drop of blood using neutrophil chemotaxis. Proc Natl Acad Sci U S A (2014) 0.89
Epidemiology of the origins of airflow limitation in asthma. Proc Am Thorac Soc (2009) 0.88
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87
Strategies for molecular classification of asthma using bipartite network analysis of cytokine expression. Curr Allergy Asthma Rep (2012) 0.86
Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma. Respir Res (2013) 0.85
ATP-binding cassette transporter 1 attenuates ovalbumin-induced neutrophilic airway inflammation. Am J Respir Cell Mol Biol (2014) 0.84
Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups. Pharmacogenomics J (2014) 0.83
Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int J Chron Obstruct Pulmon Dis (2010) 0.81
The association between systemic inflammatory cellular levels and lung function: a population-based study. PLoS One (2011) 0.80
The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions. Br J Clin Pharmacol (2015) 0.80
A comparison of the clinical and induced sputum characteristics of early- and late-onset asthma. Lung (2012) 0.78
Expression of surface markers on the blood cells during the delayed asthmatic response to allergen challenge. Allergy Rhinol (Providence) (2014) 0.78
Extracellular Vesicles, a Key Mediator to Link Environmental Microbiota to Airway Immunity. Allergy Asthma Immunol Res (2017) 0.77
High mobility group box 1: a novel mediator of Th2-type response-induced airway inflammation of acute allergic asthma. J Thorac Dis (2015) 0.76
Breathing Better Through Bugs: Asthma and the Microbiome. Yale J Biol Med (2016) 0.75
Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics. Asia Pac Allergy (2011) 0.75
Biomarkers in the Management of Difficult Asthma. Curr Top Med Chem (2016) 0.75
Airway remodeling in asthma: what really matters. Cell Tissue Res (2017) 0.75
The microbiome in asthma. Curr Opin Pediatr (2016) 0.75
Risk factors for persistent airflow limitation: Analysis of 306 patients with asthma. Pak J Med Sci (2015) 0.75
AIMAR survey on complex forms of bronchial asthma and COPD, their management and perception of critical issues. Multidiscip Respir Med (2014) 0.75
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57
Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 8.36
Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med (2014) 4.95
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med (2009) 4.83
Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med (2006) 4.83
Asthma control during the year after bronchial thermoplasty. N Engl J Med (2007) 4.79
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest (2006) 3.59
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med (2011) 3.58
Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med (2014) 3.50
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
Refining the definition of hypereosinophilic syndrome. J Allergy Clin Immunol (2010) 2.74
Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol (2012) 2.68
Prevalence, pathogenesis, and causes of chronic cough. Lancet (2008) 2.60
The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med (2007) 2.44
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax (2007) 2.37
Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest (2010) 2.29
Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol (2002) 2.28
Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels. FASEB J (2013) 2.16
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 2.13
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med (2003) 1.98
The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95
TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2002) 1.92
Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol (2008) 1.92
IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med (2010) 1.91
Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol (2005) 1.87
Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. Am J Respir Crit Care Med (2006) 1.86
Severe asthma in adults: what are the important questions? J Allergy Clin Immunol (2007) 1.85
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med (2012) 1.85
The influence of age on induced sputum differential cell counts in normal subjects. Chest (2004) 1.82
Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest (2010) 1.73
Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol (2007) 1.71
Eosinophilic airway inflammation in COPD. Int J Chron Obstruct Pulmon Dis (2006) 1.61
Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med (2006) 1.53
Detection of cough signals in continuous audio recordings using hidden Markov models. IEEE Trans Biomed Eng (2006) 1.53
Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2004) 1.52
Peptic ulceration, Helicobacter pylori seropositivity and chronic obstructive pulmonary disease. Respirology (2013) 1.45
Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol (2013) 1.45
A comparison of the validity of different diagnostic tests in adults with asthma. Chest (2002) 1.36
An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines. Chest (2006) 1.33
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J (2006) 1.30
Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study. Am J Respir Crit Care Med (2002) 1.27
Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulm Med (2011) 1.24
Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol (2008) 1.23
Cough frequency, cough sensitivity and health status in patients with chronic cough. Respir Med (2005) 1.22
Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. J Allergy Clin Immunol (2010) 1.21
Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? Thorax (2013) 1.20
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax (2010) 1.19
Inflammometry: the current state of play. Thorax (2012) 1.14
Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J Leukoc Biol (2005) 1.14
An automated system for 24-h monitoring of cough frequency: the leicester cough monitor. IEEE Trans Biomed Eng (2007) 1.14
IL-4-expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR 3 and CCR 4. J Allergy Clin Immunol (2005) 1.13
The chemokine CXCL16 is highly and constitutively expressed by human bronchial epithelial cells. Exp Lung Res (2009) 1.12
Eosinophils as diagnostic tools in chronic lung disease. Expert Rev Respir Med (2013) 1.12
Aminoglycoside suppression of nonsense mutations in severe hemophilia. Blood (2005) 1.10
Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. PLoS One (2011) 1.05