Published in FASEB J on November 18, 2013
Adrenal cortex expression quantitative trait loci in a German Holstein × Charolais cross. BMC Genet (2016) 1.40
Letters to the Editor: Genetic polymorphism and soluble urokinase plasminogen activator receptor regulation. FASEB J (2015) 1.06
Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.80
Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells. Physiol Rep (2016) 0.77
Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma. Eur Respir J (2016) 0.75
Response. FASEB J (2015) 0.75
The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro. PLoS One (2016) 0.75
Genetics and Genomics of Longitudinal Lung Function Patterns in Asthmatics. Am J Respir Crit Care Med (2016) 0.75
Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study. Circ Cardiovasc Genet (2016) 0.75
Computational analysis of multimorbidity between asthma, eczema and rhinitis. PLoS One (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
Population structure and eigenanalysis. PLoS Genet (2006) 37.21
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54
Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics (2011) 12.98
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res (2011) 11.03
WGAViewer: software for genomic annotation of whole genome association studies. Genome Res (2008) 7.15
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35
uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol (2002) 6.24
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem (1991) 2.68
suPAR: the molecular crystal ball. Dis Markers (2009) 2.55
Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell (2001) 2.21
Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet (2012) 2.09
Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. J Intern Med (2010) 2.07
Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis. Blood (2010) 1.73
Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection. Blood (2000) 1.69
The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett (2009) 1.68
Soluble urokinase plasminogen activator receptor (suPAR) for assessment of disease severity in ventilator-associated pneumonia and sepsis. J Infect (2011) 1.62
Mechanisms in COPD: differences from asthma. Chest (2000) 1.60
The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator. J Biol Chem (1991) 1.52
The role of the epithelium in airway remodeling in asthma. Proc Am Thorac Soc (2009) 1.52
Remodeling in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 1.51
Bradykinin receptor ligands: therapeutic perspectives. Nat Rev Drug Discov (2004) 1.44
Sputum cathelicidin, urokinase plasminogen activation system components, and cytokines discriminate cystic fibrosis, COPD, and asthma inflammation. Chest (2005) 1.44
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J (2006) 1.42
Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem (2006) 1.37
Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am J Respir Crit Care Med (2007) 1.36
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med (2009) 1.35
Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor. Curr Pharm Des (2003) 1.35
Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors. Stem Cells (2008) 1.30
Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression. J Cell Physiol (1999) 1.30
Human plasma kallikrein releases neutrophil elastase during blood coagulation. J Clin Invest (1983) 1.22
Role of plasma kallikrein in diabetes and metabolism. Thromb Haemost (2013) 1.22
Soluble urokinase plasminogen activator receptor is a marker of dysmetabolism in HIV-infected patients receiving highly active antiretroviral therapy. J Med Virol (2008) 1.18
Cell-surface acceleration of urokinase-catalyzed receptor cleavage. Eur J Biochem (1997) 1.16
High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation. Blood (1998) 1.14
Analysis of the invasion-metastasis mechanism in pancreatic cancer: involvement of plasmin(ogen) cascade proteins in the invasion of pancreatic cancer cells. Int J Oncol (2006) 1.08
Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices. Blood (2001) 1.06
Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells. BMC Cancer (2010) 1.05
Plasma suPAR levels are associated with mortality, admission time, and Charlson Comorbidity Index in the acutely admitted medical patient: a prospective observational study. Crit Care (2012) 1.05
Getting biological about the genetics of diabetes. Nat Med (2010) 1.05
PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. J Allergy Clin Immunol (2009) 1.04
uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium. Thorax (2011) 1.01
Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor. Thromb Haemost (2002) 1.01
Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator. Semin Thromb Hemost (1991) 1.01
Cellular expression of plasma prekallikrein in human tissues. Biol Chem (2007) 0.96
Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J Immunol (2004) 0.93
A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen. Thromb Res (1983) 0.92
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. J Biol Chem (2009) 0.92
PLAUR polymorphisms and lung function in UK smokers. BMC Med Genet (2009) 0.91
The urokinase receptor and the regulation of cell proliferation. Thromb Haemost (2005) 0.90
Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR). Biol Chem (2006) 0.89
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Hypertension (2013) 0.86
Urokinase receptor orchestrates the plasminogen system in airway epithelial cell function. Lung (2013) 0.86
Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells. BMC Mol Biol (2009) 0.85
Activation of the plasma kallikrein/kinin system on cells: a revised hypothesis. Thromb Haemost (1999) 0.85
The role of the urokinase receptor in epilepsy, in disorders of language, cognition, communication and behavior, and in the central nervous system. Curr Pharm Des (2011) 0.79
The urokinase receptor in hematopoietic stem cells mobilization. Curr Pharm Des (2011) 0.78
Localization of urokinase type plasminogen activator to focal adhesions requires ligation of vitronectin integrin receptors. Cell Adhes Commun (2000) 0.78
Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction. Clin Sci (Lond) (2010) 0.78
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57
Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 8.36
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52
Disordered microbial communities in asthmatic airways. PLoS One (2010) 6.35
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95
Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med (2006) 4.83
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Development, validity and responsiveness of the Clinical COPD Questionnaire. Health Qual Life Outcomes (2003) 4.41
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses. BMC Biol (2014) 4.39
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
What is intermediate care? BMJ (2004) 3.24
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17
Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab (2010) 3.15
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study. Chest (2007) 2.96
Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet (2006) 2.96
Acute effects of ozone on mortality from the "air pollution and health: a European approach" project. Am J Respir Crit Care Med (2004) 2.89
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Lung function decline in male heavy smokers relates to baseline airflow obstruction severity. Chest (2012) 2.77
Refining the definition of hypereosinophilic syndrome. J Allergy Clin Immunol (2010) 2.74
Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol (2012) 2.68
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet (2001) 2.61
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med (2003) 2.45
The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med (2007) 2.44
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet (2007) 2.41
Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol (2011) 2.39
Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J Allergy Clin Immunol (2011) 2.38
Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. J Allergy Clin Immunol (2009) 2.37
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax (2007) 2.37
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30
Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 2.28
Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol (2002) 2.28
Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project. Environ Health Perspect (2005) 2.25
Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome). Am J Hum Genet (2007) 2.22
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21
CT-quantified emphysema in male heavy smokers: association with lung function decline. Thorax (2011) 2.20
Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol (2007) 2.18
The role of bacteria in the pathogenesis and progression of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 2.17
Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16
Common and different genetic background for rheumatoid arthritis and coeliac disease. Hum Mol Genet (2009) 2.15
Clinical control of asthma associates with measures of airway inflammation. Thorax (2012) 2.15
Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 2.10
Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet (2012) 2.09
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Predictors of 1-year mortality in patients discharged from hospital following acute exacerbation of chronic obstructive pulmonary disease. Age Ageing (2005) 2.07
Cigarette smoke-induced emphysema: A role for the B cell? Am J Respir Crit Care Med (2006) 2.05
Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. Am J Respir Crit Care Med (2009) 2.04
Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet (2004) 2.03
The Asthma-COPD Overlap Syndrome. N Engl J Med (2015) 1.99
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med (2003) 1.98
Blood pressure in 12-year-old children is associated with fatty acid composition of human milk: the prevention and incidence of asthma and mite allergy birth cohort. Hypertension (2012) 1.97
The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95
Bronchial responsiveness to adenosine 5'-monophosphate (AMP) and methacholine differ in their relationship with airway allergy and baseline FEV(1). Am J Respir Crit Care Med (2002) 1.92
TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2002) 1.92
Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol (2008) 1.92
IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med (2010) 1.91
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88
Small airway disease in asthma and COPD: clinical implications. Chest (2011) 1.86
Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet (2006) 1.84
A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med (2005) 1.82
The influence of age on induced sputum differential cell counts in normal subjects. Chest (2004) 1.82
Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. J Allergy Clin Immunol (2009) 1.82
Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease. Hum Mol Genet (2005) 1.81
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med (2014) 1.80
A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo. Chest (2007) 1.79
A sequence variant on 17q21 is associated with age at onset and severity of asthma. Eur J Hum Genet (2010) 1.74
A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med (2013) 1.73
A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines. Genome Res (2013) 1.72
Where do people die? An international comparison of the percentage of deaths occurring in hospital and residential aged care settings in 45 populations, using published and available statistics. Int J Public Health (2012) 1.72
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Am J Hum Genet (2007) 1.72