Published in Nature on October 11, 2007
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66
Membrane scission by the ESCRT-III complex. Nature (2009) 4.66
Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol (2010) 4.29
ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol (2008) 3.90
Functional reconstitution of ESCRT-III assembly and disassembly. Cell (2009) 3.52
Helical structures of ESCRT-III are disassembled by VPS4. Science (2008) 3.38
HIV-1 assembly, budding, and maturation. Cold Spring Harb Perspect Med (2012) 3.17
A role for the ESCRT system in cell division in archaea. Science (2008) 2.94
A unique cell division machinery in the Archaea. Proc Natl Acad Sci U S A (2008) 2.58
SAXS ensemble refinement of ESCRT-III CHMP3 conformational transitions. Structure (2011) 2.24
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol (2008) 2.18
Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol (2009) 1.98
ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A (2008) 1.91
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Microtubule-severing enzymes. Curr Opin Cell Biol (2009) 1.84
Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Cell (2014) 1.78
Computational model of membrane fission catalyzed by ESCRT-III. PLoS Comput Biol (2009) 1.78
Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol (2008) 1.78
Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell (2008) 1.71
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J (2010) 1.66
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell (2007) 1.63
Essential role of hIST1 in cytokinesis. Mol Biol Cell (2009) 1.62
Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell (2009) 1.57
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. Elife (2015) 1.51
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell (2009) 1.50
Multivesicular bodies mature from the trans-Golgi network/early endosome in Arabidopsis. Plant Cell (2011) 1.47
Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. Mol Biol Cell (2008) 1.46
Assembly of the AAA ATPase Vps4 on ESCRT-III. Mol Biol Cell (2010) 1.43
The ESCRT machinery at a glance. J Cell Sci (2009) 1.41
The ESCRT-related CHMP1A and B proteins mediate multivesicular body sorting of auxin carriers in Arabidopsis and are required for plant development. Plant Cell (2009) 1.39
Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations. Hum Mol Genet (2010) 1.35
Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components. Extremophiles (2008) 1.34
Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol (2008) 1.33
Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles. Mol Biol Cell (2010) 1.32
A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. J Cell Biol (2009) 1.30
Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell (2009) 1.27
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Distribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits. Science (2014) 1.19
Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast. J Cell Biol (2011) 1.17
Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. Biochem J (2009) 1.15
The ESCRT machinery: from the plasma membrane to endosomes and back again. Crit Rev Biochem Mol Biol (2014) 1.12
Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane. J Biol Chem (2011) 1.09
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition. J Biol Chem (2010) 1.08
Structure and function of the membrane deformation AAA ATPase Vps4. Biochim Biophys Acta (2011) 1.07
Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly. Mol Biol Cell (2010) 1.06
The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev Cell (2013) 1.05
Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation. J Cell Biol (2014) 1.05
Regulation of Vps4 during MVB sorting and cytokinesis. Traffic (2011) 1.04
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol (2013) 1.04
Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III. J Biol Chem (2008) 1.04
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol (2013) 1.04
Endocytic machinery protein SlaB is dispensable for polarity establishment but necessary for polarity maintenance in hyphal tip cells of Aspergillus nidulans. Eukaryot Cell (2010) 1.03
Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division. Mol Cell (2011) 1.03
An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. J Cell Biol (2013) 1.03
Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Nat Struct Mol Biol (2015) 1.03
Structural basis for ESCRT-III CHMP3 recruitment of AMSH. Structure (2011) 1.00
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem (2012) 0.99
Crenarchaeal CdvA forms double-helical filaments containing DNA and interacts with ESCRT-III-like CdvB. PLoS One (2011) 0.98
The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol (2013) 0.95
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
CC2D1A is a regulator of ESCRT-III CHMP4B. J Mol Biol (2012) 0.95
The Arabidopsis deubiquitinating enzyme AMSH3 interacts with ESCRT-III subunits and regulates their localization. Plant Cell (2011) 0.95
Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway. J Biol Chem (2012) 0.95
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization. J Biol Chem (2010) 0.92
Reverse-topology membrane scission by the ESCRT proteins. Nat Rev Mol Cell Biol (2016) 0.90
Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1. PLoS Genet (2012) 0.90
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. Mol Biol Cell (2012) 0.89
Assembly and disassembly of the ESCRT-III membrane scission complex. FEBS Lett (2011) 0.89
Wrapping up the bad news: HIV assembly and release. Retrovirology (2013) 0.88
Membrane Repair: Mechanisms and Pathophysiology. Physiol Rev (2015) 0.88
Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element. J Biol Chem (2013) 0.88
Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs. PLoS Pathog (2014) 0.87
A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5. J Biol Chem (2015) 0.87
Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B. Structure (2012) 0.85
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. Proc Natl Acad Sci U S A (2012) 0.84
Regulation of Vps4 ATPase activity by ESCRT-III. Biochem Soc Trans (2009) 0.84
Interactome of the plant-specific ESCRT-III component AtVPS2.2 in Arabidopsis thaliana. J Proteome Res (2011) 0.84
Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants. Curr Genet (2013) 0.84
Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains. J Biol Chem (2015) 0.83
Detection of protein-protein interactions through vesicle targeting. Genetics (2009) 0.83
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). J Biol Chem (2015) 0.83
Characterization of Aspergillus nidulans DidB Did2, a non-essential component of the multivesicular body pathway. Fungal Genet Biol (2010) 0.82
Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments. Elife (2015) 0.82
Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 α7 and α9 to stimulate ATP hydrolysis. J Biol Chem (2014) 0.82
Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7. Genetics (2015) 0.82
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol (2015) 0.82
Vfa1 binds to the N-terminal microtubule-interacting and trafficking (MIT) domain of Vps4 and stimulates its ATPase activity. J Biol Chem (2014) 0.81
Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition. Cell Cycle (2011) 0.81
Stable isotope labeling with amino acids in cell culture based mass spectrometry approach to detect transient protein interactions using substrate trapping. Anal Chem (2011) 0.81
A novel endosomal sorting complex required for transport (ESCRT) component in Arabidopsis thaliana controls cell expansion and development. J Biol Chem (2014) 0.80
Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III. J Cell Sci (2013) 0.80
Suppressor of K+ transport growth defect 1 (SKD1) interacts with RING-type ubiquitin ligase and sucrose non-fermenting 1-related protein kinase (SnRK1) in the halophyte ice plant. J Exp Bot (2013) 0.80
ESCRT requirements for EIAV budding. Retrovirology (2013) 0.80
Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons. PLoS One (2012) 0.79
GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes. PLoS One (2012) 0.79
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell (2006) 10.06
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell (2002) 7.32
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science (2007) 5.19
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev Cell (2002) 4.94
The ESCRT pathway. Dev Cell (2011) 4.47
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell (2008) 4.11
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat Cell Biol (2002) 3.94
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol (2008) 3.84
Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol (2003) 3.68
Functional reconstitution of ESCRT-III assembly and disassembly. Cell (2009) 3.52
ESCRTing proteins in the endocytic pathway. Trends Biochem Sci (2007) 3.48
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science (2010) 3.20
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol (2010) 3.15
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Dev Cell (2012) 2.96
A role for the ESCRT system in cell division in archaea. Science (2008) 2.94
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Dev Cell (2004) 2.86
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol Cell (2004) 2.83
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation. Dev Cell (2008) 2.74
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell (2011) 2.60
Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci (2003) 2.57
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol (2002) 2.52
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism. Mol Cell (2011) 2.50
Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell (2002) 2.48
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Mol Biol Cell (2002) 2.39
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Cell (2006) 2.38
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci (2002) 2.36
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell (2003) 2.19
Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J (2002) 2.09
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking. Proc Natl Acad Sci U S A (2005) 2.05
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA). Proc Natl Acad Sci U S A (2012) 2.04
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24. Structure (2008) 1.95
Ubiquitin and membrane protein turnover: from cradle to grave. Annu Rev Biochem (2012) 1.88
Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology. Prog Biophys Mol Biol (2004) 1.86
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell (2002) 1.84
Structure of the ESCRT-II endosomal trafficking complex. Nature (2004) 1.80
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol (2006) 1.79
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol Cell (2003) 1.78
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol Biol Cell (2004) 1.76
TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF. Nat Cell Biol (2006) 1.75
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol Biol Cell (2003) 1.72
Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. Mol Cell (2003) 1.70
Structural basis for activation and inhibition of class I phosphoinositide 3-kinases. Sci Signal (2011) 1.68
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J (2010) 1.66
TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell (2011) 1.63
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell (2007) 1.63
The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology. Curr Opin Cell Biol (2005) 1.61
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. EMBO J (2007) 1.60
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J (2004) 1.59
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. J Biol Chem (2004) 1.57
Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A (2002) 1.57
ESCRTs and human disease. Biochem Soc Trans (2009) 1.53
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol Biol Cell (2007) 1.52
Structural and functional organization of the ESCRT-I trafficking complex. Cell (2006) 1.51
Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. J Cell Biol (2006) 1.51
Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α. Structure (2011) 1.48
Lack of medication dose uniformity in commonly split tablets. J Am Pharm Assoc (Wash) (2002) 1.46
The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices. Cell (2012) 1.45
Balancing efficacy and safety in the use of oral sedation in dental outpatients. J Am Dent Assoc (2006) 1.42
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Mol Biol Cell (2008) 1.40
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. Mol Cell (2004) 1.39
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Sci Signal (2012) 1.38
ER-PM connections: sites of information transfer and inter-organelle communication. Curr Opin Cell Biol (2013) 1.36
New component of ESCRT-I regulates endosomal sorting complex assembly. J Cell Biol (2006) 1.35
Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. J Cell Biol (2008) 1.33
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. J Cell Biol (2002) 1.33
Application of USP-NF Standard to Pharmacy Compounding. Int J Pharm Compd (2013) 1.27
Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase. EMBO J (2003) 1.26
Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. EMBO J (2010) 1.26
Eisosome proteins assemble into a membrane scaffold. J Cell Biol (2011) 1.24