Published in Cell on April 07, 2006
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66
Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol (2010) 4.29
ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol (2008) 3.90
Complex archaea that bridge the gap between prokaryotes and eukaryotes. Nature (2015) 2.27
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell (2007) 2.21
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe (2007) 2.18
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. EMBO J (2007) 1.60
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Mol Biol Cell (2006) 1.42
Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Dev Cell (2008) 1.40
New component of ESCRT-I regulates endosomal sorting complex assembly. J Cell Biol (2006) 1.35
Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway. Mol Biol Cell (2006) 1.32
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A (2011) 1.22
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell (2008) 1.14
PalC, one of two Bro1 domain proteins in the fungal pH signalling pathway, localizes to cortical structures and binds Vps32. Traffic (2007) 1.11
Regulation of Tsg101 expression by the steadiness box: a role of Tsg101-associated ligase. Mol Biol Cell (2007) 1.10
The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure (2012) 1.09
Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure (2012) 1.06
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
Recombinant protein complex expression in E. coli. Curr Protoc Protein Sci (2008) 0.95
Reverse-topology membrane scission by the ESCRT proteins. Nat Rev Mol Cell Biol (2016) 0.90
Vesicle formation within endosomes: An ESCRT marks the spot. Commun Integr Biol (2012) 0.88
Wrapping up the bad news: HIV assembly and release. Retrovirology (2013) 0.88
The Arabidopsis Endosomal Sorting Complex Required for Transport III Regulates Internal Vesicle Formation of the Prevacuolar Compartment and Is Required for Plant Development. Plant Physiol (2014) 0.88
Artificial ubiquitylation is sufficient for sorting of a plasma membrane ATPase to the vacuolar lumen of Arabidopsis cells. Planta (2012) 0.87
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
A genomic-based approach combining in vivo selection in mice to identify a novel virulence gene in Leishmania. PLoS Negl Trop Dis (2008) 0.86
Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex. Structure (2012) 0.84
Where do they come from and where do they go: candidates for regulating extracellular vesicle formation in fungi. Int J Mol Sci (2013) 0.83
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells. Nucleic Acids Res (2014) 0.80
A unique N-terminal sequence in the Carnation Italian ringspot virus p36 replicase-associated protein interacts with the host cell ESCRT-I component Vps23. J Virol (2014) 0.78
Quantitative proteome analysis of temporally resolved phagosomes following uptake via key phagocytic receptors. Mol Cell Proteomics (2015) 0.77
Neuronal Functions of ESCRTs. Exp Neurobiol (2012) 0.77
ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion. Elife (2016) 0.76
Structural Stability of the coiled-coil domain of Tumor Susceptibility Gene (TSG)-101. Biochemistry (2017) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65
Maximum-likelihood density modification. Acta Crystallogr D Biol Crystallogr (2000) 20.67
Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell (2001) 12.00
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell (2001) 9.08
HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nat Med (2001) 8.38
Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol (2003) 8.13
The protein network of HIV budding. Cell (2003) 7.82
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell (2002) 7.32
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol (2001) 6.96
AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell (2003) 6.69
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell (1998) 6.07
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag). Proc Natl Acad Sci U S A (2001) 5.83
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431. J Cell Biol (1979) 5.62
Molecular architecture and functional model of the endocytic AP2 complex. Cell (2002) 5.44
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic (2000) 4.17
Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function. Proc Natl Acad Sci U S A (2002) 4.14
Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 4.04
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03
Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03
Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol (2000) 3.76
Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol (2003) 3.68
Using prime-and-switch phasing to reduce model bias in molecular replacement. Acta Crystallogr D Biol Crystallogr (2004) 3.56
Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci (2003) 3.37
Role of ESCRT-I in retroviral budding. J Virol (2003) 3.36
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol (2003) 3.07
A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli. Protein Expr Purif (2001) 2.97
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Dev Cell (2004) 2.86
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nat Struct Biol (2002) 2.66
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. J Cell Biol (2003) 2.38
Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2005) 2.36
Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A (2004) 2.28
Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome. J Cell Biol (2003) 2.17
Ubiquitin recognition by the human TSG101 protein. Mol Cell (2004) 2.17
The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem (2004) 1.92
Structure of the ESCRT-II endosomal trafficking complex. Nature (2004) 1.80
Defects in human immunodeficiency virus budding and endosomal sorting induced by TSG101 overexpression. J Virol (2003) 1.79
Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. Genes Dev (2004) 1.73
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Signaling through monoubiquitination. Curr Top Microbiol Immunol (2004) 1.66
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. J Biol Chem (2004) 1.57
Role of HIV-1 Gag domains in viral assembly. Biochim Biophys Acta (2003) 1.53
The HIV-TSG101 interface: recent advances in a budding field. Trends Microbiol (2003) 1.48
TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence. Cancer Res (2000) 1.43
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery. Trends Pharmacol Sci (2005) 1.43
Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. J Biol Chem (2004) 1.28
An ESCRT into the endosome. Mol Cell (2002) 1.03
Polycistronic expression and purification of the ESCRT-II endosomal trafficking complex. Methods Enzymol (2005) 0.83
Two-wavelength MAD phasing: in search of the optimal choice of wavelengths. Acta Crystallogr D Biol Crystallogr (1999) 0.79
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell (2002) 7.32
Ubiquitin-binding domains. Biochem J (2006) 5.32
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev Cell (2002) 4.94
Membrane scission by the ESCRT-III complex. Nature (2009) 4.66
The ESCRT pathway. Dev Cell (2011) 4.47
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell (2008) 4.11
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature (2010) 4.05
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat Cell Biol (2002) 3.94
Retromer. Curr Opin Cell Biol (2008) 3.89
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol (2003) 3.68
Functional reconstitution of ESCRT-III assembly and disassembly. Cell (2009) 3.52
ESCRTing proteins in the endocytic pathway. Trends Biochem Sci (2007) 3.48
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4. Nature (2007) 3.47
Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature (2005) 3.22
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Dev Cell (2012) 2.96
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol Cell (2004) 2.83
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation. Dev Cell (2008) 2.74
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J (2003) 2.73
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71
ATP control of dynamic P1 ParA-DNA interactions: a key role for the nucleoid in plasmid partition. Mol Microbiol (2010) 2.65
Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell (2011) 2.60
Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation. Anal Biochem (2013) 2.57
Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci (2003) 2.57
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol (2002) 2.52
Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell (2002) 2.48
Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell (2002) 2.45
Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. Proc Natl Acad Sci U S A (2011) 2.45
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Mol Biol Cell (2002) 2.39
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Cell (2006) 2.38
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci (2002) 2.36
Structural basis for endosomal targeting by the Bro1 domain. Dev Cell (2005) 2.28
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell (2007) 2.21
Crystal structure and allosteric activation of protein kinase C βII. Cell (2011) 2.19
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell (2003) 2.19
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol (2008) 2.18
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature (2002) 2.09
Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1. Nat Rev Microbiol (2007) 2.08
The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A (2008) 2.06
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking. Proc Natl Acad Sci U S A (2005) 2.05
Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J Cell Biol (2006) 2.04
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science (2013) 2.00
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24. Structure (2008) 1.95
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. EMBO J (2009) 1.88
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol (2009) 1.88
Ubiquitin and membrane protein turnover: from cradle to grave. Annu Rev Biochem (2012) 1.88
Structure of a lipid droplet protein; the PAT family member TIP47. Structure (2004) 1.85
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell (2002) 1.84
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Proc Natl Acad Sci U S A (2009) 1.82
Structure of the ESCRT-II endosomal trafficking complex. Nature (2004) 1.80
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell (2004) 1.79
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol (2006) 1.79
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol Biol Cell (2004) 1.76
TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF. Nat Cell Biol (2006) 1.75
Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nat Struct Biol (2003) 1.73
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol Biol Cell (2003) 1.72
Interaction of yeast RNA-binding proteins Nrd1 and Nab3 with RNA polymerase II terminator elements. RNA (2007) 1.72
Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature (2011) 1.70
Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol (2007) 1.69
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J (2010) 1.66
Molecular architecture of a eukaryotic DNA transposase. Nat Struct Mol Biol (2005) 1.64
TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell (2011) 1.63
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell (2007) 1.63
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J (2004) 1.61
The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology. Curr Opin Cell Biol (2005) 1.61
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. EMBO J (2007) 1.60
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J (2004) 1.59
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A (2002) 1.57
Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41. J Biol Chem (2002) 1.57
ESCRTs and human disease. Biochem Soc Trans (2009) 1.53
Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc (2010) 1.53
Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Mol Microbiol (2005) 1.53
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes. J Biol Chem (2003) 1.52
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol Biol Cell (2007) 1.52