Published in Mol Cell Biol on October 29, 2007
Genome-scale CRISPR-Cas9 knockout screening in human cells. Science (2013) 12.36
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci (2010) 3.38
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem (2008) 2.19
Multiple faces of the SAGA complex. Curr Opin Cell Biol (2010) 1.67
Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators. Genetics (2011) 1.65
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A (2010) 1.54
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J (2008) 1.44
Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival. PLoS One (2010) 1.35
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. Mol Cell Biol (2008) 1.13
Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains. Mol Cell Biol (2010) 1.12
Histone modifiers in cancer: friends or foes? Genes Cancer (2011) 1.10
Genome recognition by MYC. Cold Spring Harb Perspect Med (2014) 1.10
The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol (2008) 1.09
Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression. J Biol Chem (2012) 1.03
ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep (2010) 1.00
Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One (2011) 0.96
Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function. Cell Rep (2012) 0.91
Activation of a poised RNAPII-dependent promoter requires both SAGA and mediator. Genetics (2010) 0.89
Sequence specificity incompletely defines the genome-wide occupancy of Myc. Genome Biol (2014) 0.89
Analysis of differential expression of Mediator subunit genes in Arabidopsis. Plant Signal Behav (2012) 0.88
MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harb Perspect Med (2014) 0.88
Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem (2014) 0.87
The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification. Nucleic Acids Res (2014) 0.85
Functions of SAGA in development and disease. Epigenomics (2014) 0.85
The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res (2009) 0.84
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits. Biochim Biophys Acta (2014) 0.79
The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter. Nucleic Acids Res (2014) 0.78
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex in Aspergillus nidulans. PLoS One (2013) 0.77
Arabidopsis HOOKLESS1 Regulates Responses to Pathogens and Abscisic Acid through Interaction with MED18 and Acetylation of WRKY33 and ABI5 Chromatin. Plant Cell (2016) 0.76
Purification of multiprotein histone acetyltransferase complexes. Methods Mol Biol (2012) 0.75
Chromatin targeting: A BET inhibitor workaround. Nat Chem Biol (2016) 0.75
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells. Int J Mol Sci (2017) 0.75
MYC-Master Regulator of the Cancer Epigenome and Transcriptome. Genes (Basel) (2017) 0.75
The role of chromatin during transcription. Cell (2007) 26.48
Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev (2000) 9.36
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell (2005) 8.92
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
Histone-like TAFs within the PCAF histone acetylase complex. Cell (1998) 5.26
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
Histone acetyltransferase complexes: one size doesn't fit all. Nat Rev Mol Cell Biol (2007) 5.12
Mediator and the mechanism of transcriptional activation. Trends Biochem Sci (2005) 4.79
A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae. Mol Cell (2004) 4.54
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol (1999) 3.90
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol (2000) 3.86
Global position and recruitment of HATs and HDACs in the yeast genome. Mol Cell (2004) 3.74
A transcription reinitiation intermediate that is stabilized by activator. Nature (2000) 3.65
Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett (2005) 3.57
The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4. Genes Dev (2001) 3.54
Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell (2005) 3.46
The diverse functions of histone acetyltransferase complexes. Trends Genet (2003) 3.35
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol Cell Biol (2001) 3.31
SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae. Genes Dev (1992) 3.31
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res (2004) 3.30
The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci (2005) 3.25
MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep (2003) 3.24
SAGA is an essential in vivo target of the yeast acidic activator Gal4p. Genes Dev (2001) 3.23
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev (2001) 3.15
The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. Genes Dev (1999) 3.15
Multiple tumor suppressor pathways negatively regulate telomerase. Cell (2003) 2.82
RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell (2006) 2.77
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Mol Cell (2007) 2.71
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71
A mechanism for coordinating chromatin modification and preinitiation complex assembly. Mol Cell (2006) 2.69
Independent recruitment in vivo by Gal4 of two complexes required for transcription. Mol Cell (2003) 2.48
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem (1999) 2.43
A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. J Biol Chem (1998) 2.40
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem (2001) 2.36
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci U S A (2001) 2.33
H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell (2007) 2.32
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet (2000) 2.20
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J (2004) 2.19
Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA. Mol Cell (2006) 2.16
Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. PLoS Biol (2006) 2.12
Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol (2004) 2.10
Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters. Mol Cell Biol (2000) 2.00
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A (2000) 1.99
In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev (2004) 1.99
Ras induces mediator complex exchange on C/EBP beta. Mol Cell (2004) 1.98
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway. Mol Cell Biol (2002) 1.98
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.97
Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol (2006) 1.91
Analysis of Spt7 function in the Saccharomyces cerevisiae SAGA coactivator complex. Mol Cell Biol (2002) 1.87
New problems in RNA polymerase II transcription initiation: matching the diversity of core promoters with a variety of promoter recognition factors. J Biol Chem (2007) 1.86
Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions. Mol Cell (2006) 1.86
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol (2002) 1.80
The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding. Mol Cell Biol (2007) 1.75
Retracted Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell (2002) 1.75
Multi-protein complexes in eukaryotic gene transcription. Plant Mol Biol (2002) 1.73
Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins. Mol Cell Biol (1997) 1.69
SAGA unveiled. Trends Biochem Sci (2005) 1.67
The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. Mol Cell (2000) 1.65
SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. Proc Natl Acad Sci U S A (2002) 1.62
The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. Genes Dev (2001) 1.55
Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol (2005) 1.54
Interdependent recruitment of SAGA and Srb mediator by transcriptional activator Gcn4p. Mol Cell Biol (2005) 1.47
Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J Biol Chem (2006) 1.46
E2F transcriptional activation requires TRRAP and GCN5 cofactors. J Biol Chem (2001) 1.44
Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7. Mol Cell Biol (2001) 1.38
Positive and negative functions of the SAGA complex mediated through interaction of Spt8 with TBP and the N-terminal domain of TFIIA. Genes Dev (2004) 1.29
The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription. Mol Cell Biol (2005) 1.26
Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS. EMBO J (2004) 1.24
c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem (2003) 1.24
SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment. EMBO J (2006) 1.21
Targeting of Swi/Snf to the yeast GAL1 UAS G requires the Mediator, TAF IIs, and RNA polymerase II. EMBO J (2004) 1.20
TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol (2005) 1.17
The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol Cell (2003) 1.15
A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. Mol Cell Biol (2003) 1.15
Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator. Mol Cell Biol (2005) 1.10
Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator. Proc Natl Acad Sci U S A (2007) 1.10
ATP-dependent nucleosome remodeling and histone hyperacetylation synergistically facilitate transcription of chromatin. J Biol Chem (2001) 1.09
Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. PLoS One (2007) 1.08
Retracted An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. J Biol Chem (2005) 1.04
Independent recruitment of mediator and SAGA by the activator Met4. Mol Cell Biol (2006) 1.01
TATA-binding protein-free TAF-containing complex (TFTC) and p300 are both required for efficient transcriptional activation. J Biol Chem (2002) 1.01
Activation of the Gal1 gene of yeast by pairs of 'non-classical' activators. Curr Biol (2004) 0.83
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature (2013) 2.63
Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene (2006) 2.31
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem (2008) 2.19
Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development (2005) 1.84
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell (2006) 1.81
A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res (2008) 1.80
Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res (2011) 1.69
NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer. J Clin Invest (2006) 1.61
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol (2005) 1.54
The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Genes Dev (2010) 1.27
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc Natl Acad Sci U S A (2012) 1.26
c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem (2003) 1.24
Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenes Res (2010) 1.12
Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc. Anticancer Res (2010) 1.08
Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog. Stem Cells (2013) 1.00
Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun (2005) 0.98
Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli. Protein Expr Purif (2004) 0.96
The MGF expression of osteoblasts in response to mechanical overload. Arch Oral Biol (2006) 0.89
The effect of step-wise increased stretching on rat calvarial osteoblast collagen production. J Biomech (2004) 0.84
Max is acetylated by p300 at several nuclear localization residues. Biochem J (2007) 0.83
Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription. Genes Dev (2011) 0.82
Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis. PLoS One (2013) 0.80
Autonomously replicating plasmid transforms Sorangium cellulosum So ce90 and induces expression of green fluorescent protein. J Biosci Bioeng (2007) 0.77
Expression, purification, and characterization of a human recombinant 17beta-hydroxysteroid dehydrogenase type 1 in Escherichia coli. Mol Biotechnol (2010) 0.77
The stress reaction and its molecular events: splicing variants. Biochem Biophys Res Commun (2004) 0.77
Enhancing the antibacterial activity of biomimetic HA coatings by incorporation of norvancomycin. J Orthop Sci (2011) 0.76
Evaluation of the biocompatibility of acellular porcine dermis. Colloids Surf B Biointerfaces (2007) 0.76
Atomic force microscopy of actin. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) (2003) 0.76
Purification of multiprotein histone acetyltransferase complexes. Methods Mol Biol (2012) 0.75
Cloning, characterization and functional expression of a new beta-D-fructofuranosidase (Os beta fruct2) cDNA from Oryza sativa. Biotechnol Lett (2003) 0.75
[Variational structure and function of products from IGF-1 gene]. Sheng Li Ke Xue Jin Zhan (2008) 0.75
[IGF-1 alternative splice isoforms: mechano growth factor]. Sheng Li Ke Xue Jin Zhan (2005) 0.75
Preliminarily investigating the polymorphism of self-organized actin filament in vitro by atomic force microscope. Acta Biochim Biophys Sin (Shanghai) (2004) 0.75
[Effects of mechanical strain on the proliferation of pulmonary epithelial cells and reorganization of integrins]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) (2002) 0.75