Published in Proc Natl Acad Sci U S A on September 17, 2012
Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell (2013) 1.67
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell (2013) 1.42
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J (2012) 1.23
Molecular control of induced pluripotency. Cell Stem Cell (2014) 1.22
Anatomy of a blastocyst: cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo. Genesis (2013) 1.21
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J (2013) 1.16
Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. Cell Res (2012) 1.12
SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. EMBO J (2013) 1.09
Network plasticity of pluripotency transcription factors in embryonic stem cells. Nat Cell Biol (2015) 1.03
Mapping the route from naive pluripotency to lineage specification. Philos Trans R Soc Lond B Biol Sci (2014) 1.01
Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog. Stem Cells (2013) 1.00
Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97
A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Mol Cell (2014) 0.94
The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states. Curr Opin Genet Dev (2013) 0.93
A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells. Mol Syst Biol (2013) 0.89
Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency. Cell Regen (Lond) (2015) 0.87
The extended pluripotency protein interactome and its links to reprogramming. Curr Opin Genet Dev (2014) 0.86
A model-based analysis of culture-dependent phenotypes of mESCs. PLoS One (2014) 0.85
Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1. PLoS One (2013) 0.84
Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions. PLoS One (2014) 0.83
ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4. Oncogene (2015) 0.79
Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells. Stem Cells Int (2015) 0.78
Induced Pluripotent Stem Cells: Generation Strategy and Epigenetic Mystery behind Reprogramming. Stem Cells Int (2016) 0.77
Cell Fate Specification Based on Tristability in the Inner Cell Mass of Mouse Blastocysts. Biophys J (2016) 0.77
The role of Nanog expression in tamoxifen-resistant breast cancer cells. Onco Targets Ther (2015) 0.76
Reprogramming Roadblocks Are System Dependent. Stem Cell Reports (2015) 0.75
Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α. J Biol Chem (2016) 0.75
MBD3 inhibits formation of liver cancer stem cells. Oncotarget (2016) 0.75
Retracted Regulatory factors of induced pluripotency: current status. Stem Cell Investig (2014) 0.75
Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer. BMC Cancer (2016) 0.75
A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Nucleic Acids Res (2017) 0.75
Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen. BMC Bioinformatics (2015) 0.75
Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible? PLoS One (2017) 0.75
An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells. NPJ Syst Biol Appl (2017) 0.75
Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches. Stem Cells Int (2017) 0.75
New factors in mammalian DNA repair-the chromatin connection. Oncogene (2017) 0.75
NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression. Stem Cell Reports (2017) 0.75
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
A protein interaction network for pluripotency of embryonic stem cells. Nature (2006) 9.63
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc (2007) 7.01
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature (2009) 5.46
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell (2009) 3.55
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2010) 2.25
Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells (2008) 2.20
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol (2008) 1.95
Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol (2010) 1.86
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72
Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res (2011) 1.69
The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol (2008) 1.41
Zfp143 regulates Nanog through modulation of Oct4 binding. Stem Cells (2008) 1.27
A protein roadmap to pluripotency and faithful reprogramming. Cells Tissues Organs (2008) 0.86
Regulation of the Nanog gene by both positive and negative cis-regulatory elements in embryonal carcinoma cells and embryonic stem cells. Mol Reprod Dev (2009) 0.84
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
A stem cell molecular signature. Science (2002) 14.47
Dissecting self-renewal in stem cells with RNA interference. Nature (2006) 11.66
Stem cells and their niches. Science (2006) 7.86
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci (2006) 4.49
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04
shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell (2007) 3.40
Systems biology of stem cell fate and cellular reprogramming. Nat Rev Mol Cell Biol (2009) 2.93
Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell (2013) 2.71
Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature (2009) 2.70
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature (2013) 2.63
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.55
A genomewide functional network for the laboratory mouse. PLoS Comput Biol (2008) 2.25
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol (2011) 2.22
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem (2008) 2.19
Affinity adsorption of lysozyme with Reactive Red 120 modified magnetic chitosan microspheres. Food Chem (2013) 2.04
Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc (2009) 1.94
Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood (2011) 1.86
Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol (2010) 1.86
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol Cell Biol (2007) 1.78
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. Blood (2011) 1.76
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell (2012) 1.71
Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res (2011) 1.69
Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev (2008) 1.68
Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat Cell Biol (2012) 1.56
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A (2002) 1.53
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nat Cell Biol (2013) 1.45
Stem cells: interactive niches. Nature (2003) 1.42
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat Commun (2013) 1.39
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev (2009) 1.39
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun (2012) 1.37
Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36
Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2006) 1.35
Diversification of stem cell molecular repertoire by alternative splicing. Proc Natl Acad Sci U S A (2005) 1.27
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells (2011) 1.22
Epigenetic roles of MLL oncoproteins are dependent on NF-κB. Cancer Cell (2013) 1.20
Statistical mechanics of pluripotency. Cell (2013) 1.16
A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover. Blood (2002) 1.13
Stem cells and reprogramming: breaking the epigenetic barrier? Trends Pharmacol Sci (2011) 1.12
Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci (2012) 1.10
ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells. Database (Oxford) (2013) 1.10
Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol (2006) 1.09
Epigenetic reprogramming induces the expansion of cord blood stem cells. J Clin Invest (2014) 1.09
Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc. Anticancer Res (2010) 1.08
Toward a complete in silico, multi-layered embryonic stem cell regulatory network. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06
Delivery of short hairpin RNAs--triggers of gene silencing--into mouse embryonic stem cells. Nat Methods (2006) 1.05
GATE: software for the analysis and visualization of high-dimensional time series expression data. Bioinformatics (2009) 1.05
Crystal orientation tuning of LiFePO4 nanoplates for high rate lithium battery cathode materials. Nano Lett (2012) 1.05
Magnetic nanoscaled Fe3O4/CeO2 composite as an efficient Fenton-like heterogeneous catalyst for degradation of 4-chlorophenol. Environ Sci Technol (2012) 1.04
Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog. Stem Cells (2013) 1.00
Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun (2005) 0.98
A heterogeneous Fenton-like system with nanoparticulate zero-valent iron for removal of 4-chloro-3-methyl phenol. J Hazard Mater (2010) 0.97
Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells (2011) 0.97
Switching on pluripotency: a perspective on the biological requirement of Nanog. Philos Trans R Soc Lond B Biol Sci (2011) 0.97
Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development (2011) 0.96
Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli. Protein Expr Purif (2004) 0.96
"Tie-ing" down the hematopoietic niche. Cell (2004) 0.95
Removal of Pb2+, Ag+, Cs+ and Sr2+ from aqueous solution by brewery's waste biomass. J Hazard Mater (2007) 0.94
NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells. Cancer Res (2012) 0.93
Reprogramming cell fates: insights from combinatorial approaches. Ann N Y Acad Sci (2012) 0.93
A new paradigm for the closed-loop intraoperative administration of analgesics in humans. IEEE Trans Biomed Eng (2002) 0.93
Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders. Curr Opin Cardiol (2011) 0.92
Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Nat Protoc (2012) 0.91
SVM classifier to predict genes important for self-renewal and pluripotency of mouse embryonic stem cells. BMC Syst Biol (2010) 0.90
Genomic editing tools to model human diseases with isogenic pluripotent stem cells. Stem Cells Dev (2014) 0.89
Toxic effects of amoxicillin on the photosystem II of Synechocystis sp. characterized by a variety of in vivo chlorophyll fluorescence tests. Aquat Toxicol (2008) 0.88
Delayed differentiation in embryonic stem cells and mesodermal progenitors in the absence of CtBP2. Mech Dev (2009) 0.86
Patterning pluripotency in embryonic stem cells. Stem Cells (2013) 0.86
Nitrogen-enriched hierarchically porous carbons prepared from polybenzoxazine for high-performance supercapacitors. ACS Appl Mater Interfaces (2014) 0.86
Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. Proc Natl Acad Sci U S A (2011) 0.86
Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors. PLoS One (2012) 0.86
Exploration of self-renewal and pluripotency in ES cells using RNAi. Methods Enzymol (2010) 0.85
SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics (2013) 0.85
Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes. Mol Med Rep (2013) 0.85
Cadmium sorption by EPSs produced by anaerobic sludge under sulfate-reducing conditions. J Hazard Mater (2006) 0.84
Comparison of polyurethane foam and biodegradable polymer as carriers in moving bed biofilm reactor for treating wastewater with a low C/N ratio. Chemosphere (2011) 0.84
Linking incomplete reprogramming to the improved pluripotency of murine embryonal carcinoma cell-derived pluripotent stem cells. PLoS One (2010) 0.84
Denitrification performance and biofilm characteristics using biodegradable polymers PCL as carriers and carbon source. Chemosphere (2013) 0.83