Published in Nature on November 29, 2007
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How degrading: Cyp26s in hindbrain development. Dev Dyn (2008) 1.14
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling. Development (2010) 1.13
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Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells. Proc Natl Acad Sci U S A (2013) 1.11
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. Curr Opin Genet Dev (2010) 1.10
Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci (2009) 1.09
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Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev (2009) 1.08
Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci (2012) 1.07
Visualisation and quantification of morphogen gradient formation in the zebrafish. PLoS Biol (2009) 1.07
Theoretical and experimental approaches to understand morphogen gradients. Mol Syst Biol (2008) 1.04
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development (2011) 1.03
Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci (2010) 1.02
Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome. Dev Biol (2009) 1.02
Morphogen rules: design principles of gradient-mediated embryo patterning. Development (2015) 1.01
Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells. Cell Mol Life Sci (2010) 1.01
Dynamics and precision in retinoic acid morphogen gradients. Curr Opin Genet Dev (2012) 1.00
Spatiotemporal mechanisms of morphogen gradient interpretation. Curr Opin Genet Dev (2011) 1.00
Robust generation and decoding of morphogen gradients. Cold Spring Harb Perspect Biol (2009) 0.99
Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. Am J Pathol (2015) 0.98
Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet (2012) 0.98
Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS. Development (2011) 0.98
The transcriptional repressor REST/NRSF modulates hedgehog signaling. Dev Biol (2010) 0.97
G-protein-coupled receptors, Hedgehog signaling and primary cilia. Semin Cell Dev Biol (2014) 0.96
Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. Elife (2013) 0.96
The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development. PLoS One (2013) 0.93
Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube. Development (2013) 0.93
Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development (2013) 0.92
Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling. Cell Rep (2013) 0.91
A theoretical framework for the regulation of Shh morphogen-controlled gene expression. Development (2014) 0.91
Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response. PLoS One (2011) 0.91
A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices (2010) 0.90
Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking. Nat Cell Biol (2011) 0.90
Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity. PLoS Biol (2014) 0.89
Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Dev Biol (2009) 0.89
Stochastic nanoroughness modulates neuron-astrocyte interactions and function via mechanosensing cation channels. Proc Natl Acad Sci U S A (2014) 0.88
The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development (2010) 0.88
Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem (2013) 0.88
An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet (2013) 0.88
Discovery and assessment of conserved Pax6 target genes and enhancers. Genome Res (2011) 0.88
Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem Cells Dev (2012) 0.88
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. Nat Commun (2015) 0.87
Regulation of thalamic development by sonic hedgehog. Front Neurosci (2012) 0.87
Hedgehog signaling is required at multiple stages of zebrafish tooth development. BMC Dev Biol (2010) 0.87
Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development (2012) 0.87
An inducible transgene expression system for zebrafish and chick. Development (2013) 0.87
Transcriptional regulation of graded Hedgehog signaling. Semin Cell Dev Biol (2014) 0.86
Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol (2013) 0.86
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Classification of transient behaviours in a time-dependent toggle switch model. BMC Syst Biol (2014) 0.86
Forming and interpreting gradients in the early Xenopus embryo. Cold Spring Harb Perspect Biol (2009) 0.86
A gene regulatory motif that generates oscillatory or multiway switch outputs. J R Soc Interface (2012) 0.86
Getting the measure of positional information. PLoS Biol (2009) 0.86
Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation. Front Neurosci (2012) 0.86
Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. J Neurosci (2012) 0.85
Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. Elife (2015) 0.84
Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs. Dev Cell (2016) 0.83
Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance. Development (2014) 0.83
PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol (2013) 0.83
Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina. J Neurosci (2013) 0.83
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems. Neural Dev (2015) 0.83
From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate. Dev Biol (2014) 0.83
Homeoprotein signaling in the developing and adult nervous system. Neuron (2015) 0.83
Hedgehog activity controls opening of the primary mouth. Dev Biol (2014) 0.82
Polycomb repressive complex 1 activities determine the columnar organization of motor neurons. Genes Dev (2012) 0.82
Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci (2003) 5.65
Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem (2003) 3.40
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The interpretation of morphogen gradients. Development (2006) 3.28
The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell (2005) 2.67
Neural crest development is regulated by the transcription factor Sox9. Development (2003) 2.62
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell (2012) 2.54
Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells (2009) 2.51
Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron (2008) 2.44
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal (2009) 2.05
Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. J Neurosci (2005) 1.92
Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron (2012) 1.86
Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2008) 1.78
SOX9 induces and maintains neural stem cells. Nat Neurosci (2010) 1.74
The floor plate: multiple cells, multiple signals. Nat Rev Neurosci (2005) 1.71
Gli proteins and the control of spinal-cord patterning. EMBO Rep (2003) 1.68
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev (2005) 1.68
Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol (2011) 1.66
Morphogens and the control of cell proliferation and patterning in the spinal cord. Cell Cycle (2007) 1.63
Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci (2005) 1.59
Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol (2010) 1.58
Oncogenicity of the developmental transcription factor Sox9. Cancer Res (2012) 1.55
A fluorescent reporter of caspase activity for live imaging. Proc Natl Acad Sci U S A (2008) 1.55
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev (2010) 1.51
Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci (2008) 1.48
HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A (2007) 1.43
The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. Genes Dev (2006) 1.42
Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. Cold Spring Harb Perspect Biol (2009) 1.41
ANKH and susceptibility to and severity of ankylosing spondylitis. J Rheumatol (2011) 1.40
Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron (2012) 1.37
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol (2009) 1.36
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol (2011) 1.36
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development (2006) 1.35
Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A (2006) 1.30
Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci (2009) 1.26
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell (2012) 1.18
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell (2007) 1.18
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr Biol (2007) 1.18
Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy. Stem Cells (2005) 1.17
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci (2007) 1.17
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling. Development (2010) 1.13
Temporal dynamics of patterning by morphogen gradients. Curr Opin Genet Dev (2009) 1.08
Coffee (Coffea arabica L.) genes early expressed during infection by the rust fungus (Hemileia vastatrix). Mol Plant Pathol (2004) 1.07
Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol (2010) 1.07
Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development (2011) 1.07
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature (2009) 1.06
Concepts and mechanisms of generalized central nervous system arousal. Ann N Y Acad Sci (2008) 1.00
The role of the estrogen receptor alpha in the medial amygdala and ventromedial nucleus of the hypothalamus in social recognition, anxiety and aggression. Behav Brain Res (2010) 1.00
Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development. Dev Dyn (2009) 1.00
Primary cilia and graded Sonic Hedgehog signaling. Wiley Interdiscip Rev Dev Biol (2012) 0.98
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development (2009) 0.98
Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons. PLoS One (2012) 0.98
Developmental pattern formation: insights from physics and biology. Science (2012) 0.97
Long-term reparative effects of mesenchymal stem cell therapy following neonatal hyperoxia-induced lung injury. Pediatr Res (2012) 0.97
Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development (2011) 0.97
The antiviral response to gamma interferon. J Virol (2002) 0.96
SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. PLoS One (2010) 0.95
Epithelial organisation revealed by a network of cellular contacts. Nat Commun (2011) 0.95
Morphogen interpretation: the transcriptional logic of neural tube patterning. Curr Opin Genet Dev (2013) 0.95
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Mol Pharmacol (2003) 0.94
Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development (2011) 0.94
Genetic characterisation of the ethambutol resistance-determining region in Mycobacterium tuberculosis: prevalence and significance of embB306 mutations. Int J Antimicrob Agents (2008) 0.94
Glomus tumor of digital nerve: case report. J Hand Surg Am (2012) 0.94
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development (2012) 0.93
The generation and diversification of spinal motor neurons: signals and responses. Mech Dev (2004) 0.93
Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube. Development (2013) 0.93
An intuitive graphical visualization technique for the interrogation of transcriptome data. Nucleic Acids Res (2011) 0.92
Estrogen-induced sexual incentive motivation, proceptivity and receptivity depend on a functional estrogen receptor alpha in the ventromedial nucleus of the hypothalamus but not in the amygdala. Neuroendocrinology (2009) 0.89
Genetic diversity in Hemileia vastatrix based on RAPD markers. Mycologia (2006) 0.88
Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn (2005) 0.88
An inducible transgene expression system for zebrafish and chick. Development (2013) 0.87
Reflectance confocal microscopy use in one case of Pityriasis folliculorum: a Demodex folliculorum analysis and comparison to other diagnostic methods. Int J Dermatol (2013) 0.87
Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol (2013) 0.86
A gene regulatory motif that generates oscillatory or multiway switch outputs. J R Soc Interface (2012) 0.86
Murine mesenchymal and embryonic stem cells express a similar Hox gene profile. Biochem Biophys Res Commun (2005) 0.86
High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event. J Cancer Res Clin Oncol (2011) 0.86
Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling. Proc Natl Acad Sci U S A (2013) 0.85
Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A (2013) 0.84
Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube. PLoS Genet (2013) 0.83
An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates. PLoS One (2007) 0.83
PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol (2013) 0.83
Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome. Dis Model Mech (2013) 0.81
Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates. Stem Cells (2011) 0.80
All the embryo's a stage, and Olig2 in its time plays many parts. Neuron (2011) 0.80