Published in Biochemistry on December 08, 2007
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
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A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30
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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
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Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
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Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
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Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts. Genome Res (2008) 3.33
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest (2013) 3.25
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
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The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design. Microbiol Mol Biol Rev (2008) 3.16
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Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood (2007) 3.09
Quantum-sized carbon dots for bright and colorful photoluminescence. J Am Chem Soc (2006) 3.08
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Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron (2006) 2.88
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli. J Exp Med (2004) 2.81
Health effects of the 2003 Southern California wildfires on children. Am J Respir Crit Care Med (2006) 2.81
Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol (2003) 2.79
Heritability of alternative splicing in the human genome. Genome Res (2007) 2.76
Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell (2005) 2.75
Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica (2006) 2.75
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother (2012) 2.65
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A novel sRNA component of the carbon storage regulatory system of Escherichia coli. Mol Microbiol (2003) 2.63
Ancient pinnate leaf mimesis among lacewings. Proc Natl Acad Sci U S A (2010) 2.56
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell (2002) 2.51
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50
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A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44
Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol (2002) 2.43
c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41
Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol (2010) 2.40
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Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol (2009) 2.36
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer (2008) 2.35
Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. Opt Lett (2007) 2.34
In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol (2006) 2.33
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Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother (2011) 2.30
Comparative analysis of bat genomes provides insight into the evolution of flight and immunity. Science (2012) 2.29
Activator control of nucleosome occupancy in activation and repression of transcription. PLoS Biol (2008) 2.29
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature (2012) 2.26
The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25
The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period. Behav Neurosci (2010) 2.23
Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS One (2009) 2.21
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. J Bacteriol (2005) 2.16
Acute phase homocysteine related to severity and outcome of atherothrombotic stroke. Eur J Intern Med (2013) 2.13
c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res (2002) 2.11
Immune-related microRNAs are abundant in breast milk exosomes. Int J Biol Sci (2011) 2.11
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli. J Bacteriol (2002) 2.10
Hypertension control in community health centers across China: analysis of antihypertensive drug treatment patterns. Am J Hypertens (2013) 2.08
Gaussian Bare-Bones Differential Evolution. IEEE Trans Cybern (2013) 2.08
Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet (2007) 2.07
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07
Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res (2004) 2.07
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TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis (2010) 2.02