Published in J Biol Chem on October 06, 2010
STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol (2012) 2.90
Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation. Circ Res (2011) 1.47
Store-Operated Calcium Channels. Physiol Rev (2015) 1.46
Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr Top Membr (2013) 1.03
Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells. Cell Calcium (2011) 1.00
Stim and Orai proteins in neuronal Ca(2+) signaling and excitability. Front Cell Neurosci (2015) 0.99
The closing and opening of TRPC channels by Homer1 and STIM1. Acta Physiol (Oxf) (2011) 0.99
Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1). J Biol Chem (2014) 0.93
The TR (i)P to Ca²⁺ signaling just got STIMy: an update on STIM1 activated TRPC channels. Front Biosci (Landmark Ed) (2012) 0.91
Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Circ Res (2012) 0.90
TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes. J Biol Chem (2010) 0.88
Endoplasmic reticulum-plasma membrane junctions: structure, function and dynamics. J Physiol (2016) 0.84
The regulation of STIM1 by phosphorylation. Commun Integr Biol (2013) 0.82
Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator? Cells (2014) 0.82
Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction. Am J Physiol Cell Physiol (2016) 0.78
Impaired calcium entry into cells is associated with pathological signs of zinc deficiency. Adv Nutr (2013) 0.76
Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. Physiol Rep (2017) 0.75
Mitochondria control store-operated Ca(2+) entry through Na(+) and redox signals. EMBO J (2017) 0.75
Both Orai1 and TRPC1 are Involved in Excessive Store-Operated Calcium Entry in Striatal Neurons Expressing Mutant Huntingtin Exon 1. Front Physiol (2015) 0.75
Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes. Exp Neurobiol (2017) 0.75
MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma. Sci Rep (2017) 0.75
Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation. Sci Rep (2017) 0.75
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol (2005) 13.11
Store-operated calcium channels. Physiol Rev (2005) 11.95
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science (2006) 9.61
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J Cell Biol (2006) 6.88
Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol (2006) 6.31
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A (2007) 5.31
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J Biol Chem (2008) 4.20
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet (2006) 3.57
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry. J Biol Chem (2006) 3.39
STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Proc Natl Acad Sci U S A (2009) 2.67
Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem (2008) 2.32
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun (2009) 2.28
A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. Proc Natl Acad Sci U S A (2009) 1.57
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38
A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels. J Biol Chem (2009) 1.35
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 6.86
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron (2006) 5.48
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 5.22
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron (2006) 4.98
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11
Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci (2005) 2.96
Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron (2006) 2.79
The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci (2008) 2.73
Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. J Neurosci (2005) 2.69
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature (2003) 2.31
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
Integration of new neurons into functional neural networks. J Neurosci (2006) 2.18
Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci (2005) 2.17
Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr Opin Neurobiol (2005) 2.16
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell (2012) 2.14
Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci U S A (2008) 2.13
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11
Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology (2005) 2.10
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06
TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04
NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology (2002) 1.91
Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol (2006) 1.90
Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J Neurosci (2002) 1.88
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86
Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons. Proc Natl Acad Sci U S A (2006) 1.85
Homer proteins regulate sensitivity to cocaine. Neuron (2004) 1.83
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. J Neurosci (2003) 1.77
The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) (2008) 1.76
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology (2004) 1.72
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med (2013) 1.70
Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol (2008) 1.69
Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression. J Neurosci (2005) 1.64
Retracted Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism. Cell (2011) 1.62
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron (2010) 1.59
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accumbens. J Neurosci (2004) 1.57
Arc-dependent synapse-specific homeostatic plasticity. Proc Natl Acad Sci U S A (2010) 1.56
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci (2005) 1.55
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci (2010) 1.54
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene (2002) 1.54
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell (2011) 1.52
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci (2012) 1.49
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47
Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci (2009) 1.47
Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium (2007) 1.45
Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron (2007) 1.45
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
Homer as both a scaffold and transduction molecule. Sci STKE (2002) 1.44
TRPC channels as STIM1-regulated SOCs. Channels (Austin) (2009) 1.43
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3. J Biol Chem (2008) 1.43
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am J Physiol Gastrointest Liver Physiol (2003) 1.42
Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J Neurosci (2002) 1.40
The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol (2008) 1.40
Mitochondria and calcium in health and disease. Cell Calcium (2008) 1.39
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Homer proteins: implications for neuropsychiatric disorders. Curr Opin Neurobiol (2006) 1.38
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37