Itching for insight.

Targeted treatment of pruritus: a look into the future. Br J Dermatol (2011) 0.83

Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94

A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29

TRPM8 is required for cold sensation in mice. Neuron (2007) 5.25

Trp ion channels and temperature sensation. Annu Rev Neurosci (2006) 4.35

The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89

A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85

Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (2005) 3.63

Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54

The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol (2005) 3.53

Opposite thermosensor in fruitfly and mouse. Nature (2003) 3.04

An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91

High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci (2006) 2.83

The role of Drosophila Piezo in mechanical nociception. Nature (2012) 2.72

Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26

Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci (2007) 2.19

More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci (2006) 2.17

Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13

From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98

Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron (2009) 1.93

Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J Neurosci (2008) 1.92

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75

Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72

Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71

TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nat Commun (2013) 1.60

A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry (2006) 1.51

Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol (2011) 1.50

TRPV1 is activated by both acidic and basic pH. J Neurosci (2009) 1.37

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proc Natl Acad Sci U S A (2013) 1.34

Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci U S A (2009) 1.33

Inflammatory signals enhance piezo2-mediated mechanosensitive currents. Cell Rep (2012) 1.32

Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci (2006) 1.32

TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. PLoS One (2009) 1.30

Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci (2004) 1.07

TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nat Commun (2011) 1.03

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A (2011) 0.93

Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations. PLoS One (2013) 0.90

Neuroscience: Salty sensations. Nature (2013) 0.87

A hot new channel. Nat Neurosci (2012) 0.84

Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. J Med Chem (2014) 0.81

Channeling pain. Nat Med (2006) 0.80

Why does morphine make you itch? Cell (2011) 0.78

Scratching the surface: a role of pain-sensing TRPA1 in itch. Nat Neurosci (2011) 0.78

Channels: flies feel your pain. Nat Chem Biol (2010) 0.75

Editorial Note to: Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization. Neuron (2017) 0.75