Published in Lab Chip on January 04, 2008
The trip of the tip: understanding the growth cone machinery. Nat Rev Mol Cell Biol (2009) 3.38
Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices. Lab Chip (2010) 1.19
An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip (2009) 1.18
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors. Integr Biol (Camb) (2010) 1.09
Microfluidics and multielectrode array-compatible organotypic slice culture method. J Neurosci Methods (2008) 1.07
Direct biophotolithographic method for generating substrates with multiple overlapping biomolecular patterns and gradients. Langmuir (2009) 1.05
New perspectives on neuronal development via microfluidic environments. Trends Neurosci (2012) 1.04
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol (2011) 0.97
Microfluidic devices for cell cultivation and proliferation. Biomicrofluidics (2013) 0.90
Microfluidic investigation of BDNF-enhanced neural stem cell chemotaxis in CXCL12 gradients. Small (2012) 0.88
Gradient lithography of engineered proteins to fabricate 2D and 3D cell culture microenvironments. Biomed Microdevices (2009) 0.87
Integration of shallow gradients of Shh and Netrin-1 guides commissural axons. PLoS Biol (2015) 0.86
Superimposed topographic and chemical cues synergistically guide neurite outgrowth. Lab Chip (2013) 0.86
Less than 5 Netrin-1 molecules initiate attraction but 200 Sema3A molecules are necessary for repulsion. Sci Rep (2012) 0.86
Highly permeable silicon membranes for shear free chemotaxis and rapid cell labeling. Lab Chip (2014) 0.85
Probing dynamic cell-substrate interactions using photochemically generated surface-immobilized gradients: application to selectin-mediated leukocyte rolling. Integr Biol (Camb) (2011) 0.84
High-content neurite development study using optically patterned substrates. PLoS One (2012) 0.83
A mechanism for the polarity formation of chemoreceptors at the growth cone membrane for gradient amplification during directional sensing. PLoS One (2010) 0.83
Pulsing cells: how fast is too fast? HFSP J (2008) 0.83
An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments. Integr Biol (Camb) (2010) 0.83
Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities. Small (2014) 0.82
Sequentially pulsed fluid delivery to establish soluble gradients within a scalable microfluidic chamber array. Biomicrofluidics (2013) 0.82
Models at the single cell level. Wiley Interdiscip Rev Syst Biol Med (2010) 0.81
Microfluidic transwell inserts for generation of tissue culture-friendly gradients in well plates. Lab Chip (2013) 0.81
Amplification and temporal filtering during gradient sensing by nerve growth cones probed with a microfluidic assay. Biophys J (2012) 0.80
A mathematical model explains saturating axon guidance responses to molecular gradients. Elife (2016) 0.78
Microfluidic approaches for the fabrication of gradient crosslinked networks based on poly(ethylene glycol) and hyperbranched polymers for manipulation of cell interactions. J Biomed Mater Res A (2010) 0.78
Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons. Neural Dev (2015) 0.78
Spatial and temporal sensing limits of microtubule polarization in neuronal growth cones by intracellular gradients and forces. Biophys J (2012) 0.78
Substrate-bound protein gradients to study haptotaxis. Front Bioeng Biotechnol (2015) 0.77
Synergistic effects of 3D ECM and chemogradients on neurite outgrowth and guidance: a simple modeling and microfluidic framework. PLoS One (2014) 0.77
Semaphorin 3C Released from a Biocompatible Hydrogel Guides and Promotes Axonal Growth of Rodent and Human Dopaminergic Neurons. Tissue Eng Part A (2016) 0.77
Small-molecule axon-polarization studies enabled by a shear-free microfluidic gradient generator. Lab Chip (2014) 0.77
Ordered, random, monotonic and non-monotonic digital nanodot gradients. PLoS One (2014) 0.76
Pioneering studies on the mechanisms of neuronal morphogenesis. Dev Neurobiol (2011) 0.75
An open-chamber flow-focusing device for focal stimulation of micropatterned cells. Biomicrofluidics (2016) 0.75
Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic device for cell seeding, coherent growth, and solute delivery. Biomed Microdevices (2013) 0.75
Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy. J Vis Exp (2013) 0.75
Spatial manipulation with microfluidics. Front Bioeng Biotechnol (2015) 0.75
A microfluidic live cell assay to study anthrax toxin induced cell lethality assisted by conditioned medium. Sci Rep (2015) 0.75
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci (2006) 6.48
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron (2007) 5.31
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell (2010) 3.71
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Information transduction capacity of noisy biochemical signaling networks. Science (2011) 2.95
A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods (2005) 2.91
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol (2011) 2.59
Dynamic properties of network motifs contribute to biological network organization. PLoS Biol (2005) 2.58
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
GABA sets the tempo for activity-dependent adult neurogenesis. Trends Neurosci (2006) 2.23
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance. Neuron (2004) 2.13
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
Development of neural stem cell in the adult brain. Curr Opin Neurobiol (2008) 2.02
Microengineered platforms for cell mechanobiology. Annu Rev Biomed Eng (2009) 2.02
Focal adhesion kinase in netrin-1 signaling. Nat Neurosci (2004) 1.99
Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (2005) 1.79
Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol (2008) 1.79
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond) (2010) 1.78
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells (2008) 1.68
Modeling the cell's guidance system. Sci STKE (2002) 1.68
BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol (2007) 1.66
Adult neural stem cells in the mammalian central nervous system. Cell Res (2009) 1.64
TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron (2013) 1.64
DNA methylation presents distinct binding sites for human transcription factors. Elife (2013) 1.63
Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci (2008) 1.55
Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients. Biomaterials (2009) 1.53
A theoretical model to predict both horizontal displacement and vertical displacement for electromagnetic induction-based deep displacement sensors. Sensors (Basel) (2011) 1.53
Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics (2003) 1.53
Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol (2007) 1.52
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor. Radiology (2012) 1.51
Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. J Biol Chem (2013) 1.48
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev (2003) 1.46
Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Curr Opin Neurobiol (2005) 1.45
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43
Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. Stem Cells Dev (2015) 1.42
Diverse sensitivity thresholds in dynamic signaling responses by social amoebae. Sci Signal (2012) 1.41
Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy. Adv Funct Mater (2009) 1.39
The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol Cell Biol (2002) 1.36
mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons. Neuron (2013) 1.35
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation. Biophys J (2005) 1.34
Multiple signaling pathways regulate yeast cell death during the response to mating pheromones. Mol Biol Cell (2006) 1.29
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Axonal protective effects of the myelin-associated glycoprotein. J Neurosci (2009) 1.29
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol (2012) 1.29
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol (2008) 1.27
Negative autoregulation by FAS mediates robust fetal erythropoiesis. PLoS Biol (2007) 1.25
Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip (2009) 1.25
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules. Proc Natl Acad Sci U S A (2011) 1.24
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip (2010) 1.20
beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones. Mol Brain (2008) 1.19
Synergistically enhanced osteogenic differentiation of human mesenchymal stem cells by culture on nanostructured surfaces with induction media. Biomacromolecules (2010) 1.18
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires. Nat Nanotechnol (2010) 1.18
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal (2013) 1.17
Cell motility of neural stem cells is reduced after SPIO-labeling, which is mitigated after exocytosis. Magn Reson Med (2012) 1.16
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Robust and sensitive control of a quorum-sensing circuit by two interlocked feedback loops. Mol Syst Biol (2008) 1.14
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nat Neurosci (2013) 1.13
Matched-case comparison of neoadjuvant chemotherapy in patients with FIGO stage IB1-IIB cervical cancer to establish selection criteria. Eur J Cancer (2012) 1.10
The systems biology of glycosylation. Chembiochem (2004) 1.09
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. Nat Genet (2013) 1.09
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci Signal (2012) 1.08
Systems biology. How information theory handles cell signaling and uncertainty. Science (2012) 1.08
Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb) (2012) 1.08
Biomimetic nanopatterns as enabling tools for analysis and control of live cells. Adv Mater (2010) 1.07
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem (2009) 1.07
Time-dependent involvement of adult-born dentate granule cells in behavior. Behav Brain Res (2011) 1.06
Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb) (2012) 1.04
Modelling cell polarization driven by synthetic spatially graded Rac activation. PLoS Comput Biol (2012) 1.03
Changes in prevalence and clinical characteristics of cervical cancer in the People's Republic of China: a study of 10,012 cases from a nationwide working group. Oncologist (2013) 1.01
ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis. PLoS One (2009) 0.99
Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system. Mol Syst Biol (2008) 0.98
Dynamic localization of G-actin during membrane protrusion in neuronal motility. Curr Biol (2013) 0.98
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol (2011) 0.97
NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1). J Neurochem (2011) 0.97
Knockdown of ANLN by lentivirus inhibits cell growth and migration in human breast cancer. Mol Cell Biochem (2014) 0.96
Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol (2012) 0.94
2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett (2008) 0.94
Cryptanalysis and Enhancement of Anonymity Preserving Remote User Mutual Authentication and Session Key Agreement Scheme for E-Health Care Systems. J Med Syst (2015) 0.94
Adult neurogenesis as a cellular model to study schizophrenia. Cell Cycle (2010) 0.94
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med (2012) 0.94
The nuclear protein expression levels of SNAI1 and ZEB1 are involved in the progression and lymph node metastasis of cervical cancer via the epithelial-mesenchymal transition pathway. Hum Pathol (2013) 0.94
Use of ureteral stent in extracorporeal shock wave lithotripsy for upper urinary calculi: a systematic review and meta-analysis. J Urol (2011) 0.93
Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival. Clin Cancer Res (2014) 0.93
Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther (2009) 0.92
Oscillatory signaling processes: the how, the why and the where. Curr Opin Genet Dev (2010) 0.92
A cell-based model for quorum sensing in heterogeneous bacterial colonies. PLoS Comput Biol (2010) 0.92
Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis. Chin Med J (Engl) (2002) 0.92
[Simultaneous determination of 4 phenolic acids in cangerzi by ultra-performance liquid chromatography]. Yao Xue Xue Bao (2010) 0.92
Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway. PLoS One (2013) 0.91