Published in Sci Signal on February 28, 2012
Rescaling of Spatio-Temporal Sensing in Eukaryotic Chemotaxis. PLoS One (2016) 1.40
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci U S A (2013) 1.34
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLoS Comput Biol (2013) 1.10
Noise in biology. Rep Prog Phys (2014) 1.09
Cellular memory in eukaryotic chemotaxis. Proc Natl Acad Sci U S A (2014) 1.01
Rectified directional sensing in long-range cell migration. Nat Commun (2014) 0.97
Excitable signal transduction induces both spontaneous and directional cell asymmetries in the phosphatidylinositol lipid signaling system for eukaryotic chemotaxis. Biophys J (2014) 0.94
Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proc Natl Acad Sci U S A (2013) 0.94
Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm. J Cell Biol (2012) 0.91
The application of information theory to biochemical signaling systems. Phys Biol (2012) 0.90
Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Mol Biol Cell (2014) 0.89
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. Nat Commun (2015) 0.87
Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations. Proc Natl Acad Sci U S A (2013) 0.87
A generalizable, tunable microfluidic platform for delivering fast temporally varying chemical signals to probe single-cell response dynamics. Anal Chem (2014) 0.86
From intracellular signaling to population oscillations: bridging size- and time-scales in collective behavior. Mol Syst Biol (2015) 0.85
Limits to the precision of gradient sensing with spatial communication and temporal integration. Proc Natl Acad Sci U S A (2016) 0.83
How to understand and outwit adaptation. Dev Cell (2014) 0.82
Chemotaxis of Dictyostelium discoideum: collective oscillation of cellular contacts. PLoS One (2013) 0.81
How to train your microbe: methods for dynamically characterizing gene networks. Curr Opin Microbiol (2015) 0.81
Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture. Philos Trans R Soc Lond B Biol Sci (2013) 0.80
Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium. Biophys J (2013) 0.80
Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol (2016) 0.79
Modeling self-organized spatio-temporal patterns of PIP₃ and PTEN during spontaneous cell polarization. Phys Biol (2014) 0.79
Memory improves precision of cell sensing in fluctuating environments. Sci Rep (2014) 0.78
Quantifying collective behavior in mammalian cells. Proc Natl Acad Sci U S A (2012) 0.77
A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations. Biophys J (2014) 0.77
Regulation of Spatiotemporal Patterns by Biological Variability: General Principles and Applications to Dictyostelium discoideum. PLoS Comput Biol (2015) 0.76
Modeling oscillations and spiral waves in Dictyostelium populations. Phys Rev E Stat Nonlin Soft Matter Phys (2015) 0.76
Modeling Contact Inhibition of Locomotion of Colliding Cells Migrating on Micropatterned Substrates. PLoS Comput Biol (2016) 0.75
Collective behavior of Dictyostelium discoideum monitored by impedance analysis. Commun Integr Biol (2013) 0.75
Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs. PLoS One (2014) 0.75
Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway. PLoS Comput Biol (2016) 0.75
The structure of dynamic GPCR signaling networks. Wiley Interdiscip Rev Syst Biol Med (2014) 0.75
Excitable behavior in amoeboid chemotaxis. Wiley Interdiscip Rev Syst Biol Med (2013) 0.75
A Model for Direction Sensing in Dictyostelium discoideum: Ras Activity and Symmetry Breaking Driven by a Gβγ-Mediated, Gα2-Ric8 -- Dependent Signal Transduction Network. PLoS Comput Biol (2016) 0.75
A design principle of group-level decision making in cell populations. PLoS Comput Biol (2013) 0.75
An excitable compass guides chemotaxis? Biophys J (2014) 0.75
Physical models of collective cell motility: from cell to tissue. J Phys D Appl Phys (2017) 0.75
Oscillatory stimuli differentiate adapting circuit topologies. Nat Methods (2017) 0.75
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell (2010) 3.71
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Information transduction capacity of noisy biochemical signaling networks. Science (2011) 2.95
A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods (2005) 2.91
Dynamic properties of network motifs contribute to biological network organization. PLoS Biol (2005) 2.58
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
Microengineered platforms for cell mechanobiology. Annu Rev Biomed Eng (2009) 2.02
Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (2005) 1.79
Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol (2008) 1.79
Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol (2010) 1.75
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
Modeling the cell's guidance system. Sci STKE (2002) 1.68
Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients. Biomaterials (2009) 1.53
Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics (2003) 1.53
Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol (2007) 1.52
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor. Radiology (2012) 1.51
Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. J Biol Chem (2013) 1.48
A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. Lab Chip (2008) 1.46
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev (2003) 1.46
Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity. Mol Endocrinol (2006) 1.43
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43
Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. Stem Cells Dev (2015) 1.42
Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy. Adv Funct Mater (2009) 1.39
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation. Biophys J (2005) 1.34
Multiple signaling pathways regulate yeast cell death during the response to mating pheromones. Mol Biol Cell (2006) 1.29
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol (2012) 1.29
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol (2008) 1.27
Negative autoregulation by FAS mediates robust fetal erythropoiesis. PLoS Biol (2007) 1.25
Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip (2009) 1.25
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules. Proc Natl Acad Sci U S A (2011) 1.24
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip (2010) 1.20
Synergistically enhanced osteogenic differentiation of human mesenchymal stem cells by culture on nanostructured surfaces with induction media. Biomacromolecules (2010) 1.18
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires. Nat Nanotechnol (2010) 1.18
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal (2013) 1.17
Cell motility of neural stem cells is reduced after SPIO-labeling, which is mitigated after exocytosis. Magn Reson Med (2012) 1.16
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Robust and sensitive control of a quorum-sensing circuit by two interlocked feedback loops. Mol Syst Biol (2008) 1.14
The systems biology of glycosylation. Chembiochem (2004) 1.09
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci Signal (2012) 1.08
Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb) (2012) 1.08
Systems biology. How information theory handles cell signaling and uncertainty. Science (2012) 1.08
Biomimetic nanopatterns as enabling tools for analysis and control of live cells. Adv Mater (2010) 1.07
Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb) (2012) 1.04
Modelling cell polarization driven by synthetic spatially graded Rac activation. PLoS Comput Biol (2012) 1.03
Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system. Mol Syst Biol (2008) 0.98
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol (2011) 0.97
Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol (2012) 0.94
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med (2012) 0.94
Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival. Clin Cancer Res (2014) 0.93
Oscillatory signaling processes: the how, the why and the where. Curr Opin Genet Dev (2010) 0.92
A cell-based model for quorum sensing in heterogeneous bacterial colonies. PLoS Comput Biol (2010) 0.92
Physical transfer of membrane and cytoplasmic components as a general mechanism of cell-cell communication. J Cell Sci (2009) 0.91
The application of information theory to biochemical signaling systems. Phys Biol (2012) 0.90
Using a microfluidic device for high-content analysis of cell signaling. Sci Signal (2009) 0.88
Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells. Mol Biosyst (2009) 0.88
Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast. Cell Rep (2012) 0.87
A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction. Cell Cycle (2009) 0.87
Superimposed topographic and chemical cues synergistically guide neurite outgrowth. Lab Chip (2013) 0.86
Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction. Cancer Res (2011) 0.84
Quantitative analysis of the combined effect of substrate rigidity and topographic guidance on cell morphology. IEEE Trans Nanobioscience (2011) 0.84
Wires in the soup: quantitative models of cell signaling. Trends Cell Biol (2008) 0.83
Pulsing cells: how fast is too fast? HFSP J (2008) 0.83
An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments. Integr Biol (Camb) (2010) 0.83
Simple haptotactic gradient generation within a triangular microfluidic channel. Lab Chip (2010) 0.82
Models at the single cell level. Wiley Interdiscip Rev Syst Biol Med (2010) 0.81
Development of animal experimental periodontitis models. J Periodontal Implant Sci (2013) 0.81
Microfluidic technologies for studying synthetic circuits. Curr Opin Chem Biol (2012) 0.80
Proteomics takes stem cell analyses to another level. Nat Biotechnol (2005) 0.80
Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture. Philos Trans R Soc Lond B Biol Sci (2013) 0.80
Concise review: Mechanotransduction via p190RhoGAP regulates a switch between cardiomyogenic and endothelial lineages in adult cardiac progenitors. Stem Cells (2014) 0.79
Microfluidics technology for systems biology research. Methods Mol Biol (2009) 0.79
A method for probabilistic mapping between protein structure and function taxonomies through cross training. BMC Struct Biol (2008) 0.79
Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration. Pigment Cell Melanoma Res (2013) 0.78
Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels. PLoS One (2012) 0.78
High-content screening in microfluidic devices. Expert Opin Drug Discov (2010) 0.78
217 YAP Is Ready to Rac and Rho: Elucidation of a Novel YAP-Driven Network That Potentiates Brain Cancer Cell Dispersal and Confers Poor Survival in Patients. Neurosurgery (2016) 0.77
Control of the interface between heterotypic cell populations reveals the mechanism of intercellular transfer of signaling proteins. Integr Biol (Camb) (2015) 0.77
Visualizing molecular diffusion through passive permeability barriers in cells: conventional and novel approaches. Curr Opin Chem Biol (2013) 0.76
Principles of model building: an experimentation-aided approach to development of models for signaling networks. Methods Cell Biol (2012) 0.76
A scalable and integrative system for pathway bioinformatics and systems biology. Adv Exp Med Biol (2010) 0.75
Role of spatial averaging in multicellular gradient sensing. Phys Biol (2016) 0.75
Stem cell differentiation as a renewal-reward process: predictions and validation in the colonic crypt. Adv Exp Med Biol (2012) 0.75
Meridional vs. facial coordination geometries of a dipodal ligand framework featuring a secondary coordination sphere. Dalton Trans (2014) 0.75
Modeling intercellular transfer of biomolecules through tunneling nanotubes. Bull Math Biol (2013) 0.75