R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMID 18242177)

Published in FEBS Lett on January 31, 2008

Authors

Wenyan Lu1, Kyung-Ah Kim, Jianzhong Liu, Arie Abo, Xu Feng, Xu Cao, Yonghe Li

Author Affiliations

1: Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA.

Articles citing this

WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med (2013) 4.52

Update on Wnt signaling in bone cell biology and bone disease. Gene (2011) 2.03

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway. PLoS One (2011) 1.27

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol (2008) 1.26

Cellular signaling and biological functions of R-spondins. Cell Signal (2011) 1.25

Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling. Blood (2009) 1.25

Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene (2009) 1.21

The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol (2012) 1.09

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem (2009) 1.01

Human RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signaling. PLoS One (2011) 0.99

Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry (2010) 0.98

Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells. J Cell Biochem (2014) 0.91

PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling. Mol Biol Cell (2010) 0.91

Building pathways for ovary organogenesis in the mouse embryo. Curr Top Dev Biol (2010) 0.90

Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function. Cell Signal (2009) 0.90

Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. Cell Signal (2014) 0.87

Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cell Signal (2012) 0.87

Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma. PLoS One (2013) 0.86

The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells. PLoS One (2013) 0.85

Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea. Dev Dyn (2013) 0.84

The alliance of mesenchymal stem cells, bone, and diabetes. Int J Endocrinol (2014) 0.78

Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathway. Biomed Res Int (2014) 0.76

Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells. Oncotarget (2016) 0.75

Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation. Int J Mol Sci (2017) 0.75

RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling. Sci Rep (2017) 0.75

Articles by these authors

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25

TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med (2009) 4.58

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med (2013) 4.32

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med (2013) 2.74

R-Spondin proteins: a novel link to beta-catenin activation. Cell Cycle (2006) 2.56

R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37

Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circ Res (2007) 2.32

Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. J Biol Chem (2006) 2.31

Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev (2008) 2.22

BMP signaling in skeletal development. Biochem Biophys Res Commun (2005) 2.13

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. J Cell Biol (2004) 1.98

Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci (2005) 1.97

Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet (2012) 1.91

Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem (2001) 1.86

Endofin acts as a Smad anchor for receptor activation in BMP signaling. J Cell Sci (2007) 1.81

Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum (2005) 1.79

A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer. Clin Cancer Res (2007) 1.77

Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovasc Res (2012) 1.71

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem (2004) 1.64

R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. Gastroenterology (2007) 1.64

R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A (2009) 1.63

Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling. Cell Stem Cell (2010) 1.60

HIV increases HCV replication in a TGF-beta1-dependent manner. Gastroenterology (2008) 1.60

Pref-1, a preadipocyte secreted factor that inhibits adipogenesis. J Nutr (2006) 1.59

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57

A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver Int (2013) 1.57

Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. Cancer Res (2012) 1.55

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer Prev Res (Phila) (2009) 1.51

The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer. J Cell Biochem (2012) 1.47

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep (2002) 1.42

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res (2009) 1.38

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. J Biol Chem (2005) 1.36

A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J Immunol (2006) 1.36

TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling. Nat Cell Biol (2010) 1.33

The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. J Biol Chem (2004) 1.27

A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells. EMBO Rep (2003) 1.27

Radiofrequency ablation for the treatment of primary intrahepatic cholangiocarcinoma. AJR Am J Roentgenol (2011) 1.27

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway. PLoS One (2011) 1.27

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol (2008) 1.26

Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss. Laryngoscope (2002) 1.24

Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. J Biol Chem (2004) 1.24

PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J Cell Sci (2002) 1.24

Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol (2003) 1.24

HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE. J Bone Miner Res (2008) 1.23

Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling. J Bone Miner Res (2012) 1.22

BMP signaling and skeletogenesis. Ann N Y Acad Sci (2006) 1.22

The Tobacco mosaic virus 126-kDa protein associated with virus replication and movement suppresses RNA silencing. Mol Plant Microbe Interact (2004) 1.22

A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol (2012) 1.21

Regulation of osteoclast function and bone mass by RAGE. J Exp Med (2006) 1.21

NAC for noise: from the bench top to the clinic. Hear Res (2006) 1.20

Collecting duct carcinoma of the kidney: CT and pathologic correlation. Eur J Radiol (2005) 1.20

Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer (2008) 1.19

Thyroid hormone action at the cellular, genomic and target gene levels. Mol Cell Endocrinol (2006) 1.19

Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology (2003) 1.18

Sex-related differences in neuronal cell survival and signaling in rats. Neurosci Lett (2003) 1.17

Frizzled7 as an emerging target for cancer therapy. Cell Signal (2011) 1.16

Possible interethnic differences in quinidine-induced QT prolongation between healthy Caucasian and Korean subjects. Br J Clin Pharmacol (2006) 1.16

Smads oppose Hox transcriptional activities. Exp Cell Res (2006) 1.15

Multiplicity of BMP signaling in skeletal development. Ann N Y Acad Sci (2007) 1.15

Prevention of impulse noise-induced hearing loss with antioxidants. Acta Otolaryngol (2005) 1.14

Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains. Traffic (2003) 1.13

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells. Cancer Prev Res (Phila) (2011) 1.13

MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. Cancer Res (2007) 1.12

Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. EMBO Rep (2003) 1.12

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. J Biol Chem (2004) 1.11

Feature selection and classification of MAQC-II breast cancer and multiple myeloma microarray gene expression data. PLoS One (2009) 1.11

Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function. J Biol Chem (2004) 1.11

Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. J Bone Miner Res (2009) 1.11

c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages. J Biol Chem (2007) 1.11

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity. Cancer Prev Res (Phila) (2012) 1.11

MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest (2015) 1.10

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling. Mol Cancer Ther (2013) 1.10

Gene selection and classification for cancer microarray data based on machine learning and similarity measures. BMC Genomics (2011) 1.10

A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling. J Biol Chem (2001) 1.09

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling. J Clin Invest (2014) 1.08

Injury-activated transforming growth factor β controls mobilization of mesenchymal stem cells for tissue remodeling. Stem Cells (2012) 1.08

Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration. Acta Otolaryngol (2007) 1.07

Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. J Biol Chem (2005) 1.07

Smad4 as a transcription corepressor for estrogen receptor alpha. J Biol Chem (2003) 1.07

AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase. J Biol Chem (2007) 1.06

Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis. J Biol Chem (2009) 1.06

Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model. Am J Physiol Gastrointest Liver Physiol (2012) 1.06

[Study on the coumarin glucosides of Angelica dahurica]. Zhong Yao Cai (2012) 1.06

A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage. J Biol Chem (2005) 1.06

Clathrin light chains regulate clathrin-mediated trafficking, auxin signaling, and development in Arabidopsis. Plant Cell (2013) 1.05

ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells. J Appl Physiol (1985) (2006) 1.05

Sp1 transcription factor as a molecular target for nitric oxide-- and cyclic nucleotide--mediated suppression of cGMP-dependent protein kinase-Ialpha expression in vascular smooth muscle cells. Circ Res (2002) 1.05

R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum (2010) 1.03

TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB. J Biol Chem (2011) 1.03