Published in Nat Cell Biol on February 07, 2010
TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci (2012) 3.49
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med (2013) 2.74
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. Nat Med (2014) 1.90
Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling. Cell Stem Cell (2010) 1.60
Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling. J Bone Miner Res (2012) 1.22
The immune system and bone. Arch Biochem Biophys (2010) 1.19
Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis. J Biol Chem (2012) 1.10
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling. J Clin Invest (2014) 1.08
BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b. Mol Endocrinol (2011) 1.08
Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int (2012) 1.08
Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res (2013) 0.98
Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis. Trends Pharmacol Sci (2014) 0.96
Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation. Dev Biol (2013) 0.93
Comparison of Gene Expression in Human Embryonic Stem Cells, hESC-Derived Mesenchymal Stem Cells and Human Mesenchymal Stem Cells. Stem Cells Int (2011) 0.91
Function of matrix IGF-1 in coupling bone resorption and formation. J Mol Med (Berl) (2013) 0.90
TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression. J Cell Sci (2011) 0.90
Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. Mol Biol Cell (2016) 0.89
Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism. PLoS One (2013) 0.89
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res (2016) 0.88
FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12-ATG5 conjugate, leading to the delay of cartilage development in achondroplasia. Autophagy (2015) 0.87
Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseases. Traffic (2012) 0.86
Nuclear receptors in bone physiology and diseases. Physiol Rev (2013) 0.86
PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling. J Bone Miner Res (2015) 0.84
PTH battles TGF-beta in bone. Nat Cell Biol (2010) 0.84
Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation. J Cell Physiol (2012) 0.83
Systemic neutralization of TGF-β attenuates osteoarthritis. Ann N Y Acad Sci (2016) 0.82
G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone. J Biol Chem (2011) 0.81
Altered bone biology in psoriatic arthritis. Curr Rheumatol Rep (2012) 0.80
Parathyroid hormone induces bone formation in phosphorylation-deficient PTHR1 knockin mice. Am J Physiol Endocrinol Metab (2012) 0.79
TGF-β Signaling Regulates Cementum Formation through Osterix Expression. Sci Rep (2016) 0.78
PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. J Bone Miner Res (2015) 0.78
Functional characterization of the parathyroid hormone 1 receptor in human periodontal ligament cells. Clin Oral Investig (2013) 0.78
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res (2014) 0.77
Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability. Exp Mol Med (2016) 0.77
Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res (2017) 0.75
Fibroblast Growth Factor Receptor 3 Deficiency Does Not Impair the Osteoanabolic Action of Parathyroid Hormone on Mice. Int J Biol Sci (2016) 0.75
Tgfbr2 is required in osterix expressing cells for postnatal skeletal development. Bone (2016) 0.75
Soluble Factors on Stage to Direct Mesenchymal Stem Cells Fate. Front Bioeng Biotechnol (2017) 0.75
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06
Bone resorption by osteoclasts. Science (2000) 11.68
Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol (2005) 11.18
Transcriptional control by the TGF-beta/Smad signaling system. EMBO J (2000) 8.49
TGF beta signals through a heteromeric protein kinase receptor complex. Cell (1992) 8.12
Mechanism of activation of the TGF-beta receptor. Nature (1994) 8.10
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
Control of osteoblast function and regulation of bone mass. Nature (2003) 5.06
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell (1992) 4.68
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med (2009) 4.58
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem (2002) 4.52
Skeletal remodeling in health and disease. Nat Med (2007) 4.31
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science (1991) 4.00
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57
Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest (2001) 3.37
Roles of G-protein-coupled receptor dimerization. EMBO Rep (2004) 3.33
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Transforming growth factor-beta1 to the bone. Endocr Rev (2005) 3.13
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A (1992) 3.01
PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol (2004) 2.91
A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science (1995) 2.78
Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med (2005) 2.72
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell (2006) 2.49
Endocytosis conducts the cell signaling orchestra. Cell (2006) 2.48
Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res (2003) 2.38
Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev (2008) 2.22
PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development (2002) 2.19
TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A (2005) 1.83
Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J Clin Invest (1999) 1.73
Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development (1999) 1.69
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A (2005) 1.63
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem (2001) 1.37
Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation. J Cell Biol (1999) 1.35
Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology (1993) 1.31
Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. J Clin Invest (1995) 1.27
Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab (1993) 1.26
Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling. Mol Endocrinol (2002) 1.21
Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. J Bone Miner Res (2009) 1.11
Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem (2004) 1.10
The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem (1995) 1.00
Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure. Endocrinology (2003) 0.99
Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure. Bone (2008) 0.94
Isolation of the first piscine transforming growth factor beta gene: analysis reveals tissue specific expression and a potential regulatory sequence in rainbow trout (Oncorhynchus mykiss). Cytokine (1998) 0.94
Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1. EMBO J (2006) 0.94
Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. J Biol Chem (2003) 0.90
The phylogeny of the insulin-like growth factors. Int Rev Cytol (1998) 0.88
Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors. Curr Opin Nephrol Hypertens (1994) 0.86
Molecular isolation and characterisation of carp transforming growth factor beta 1 from activated leucocytes. Fish Shellfish Immunol (2000) 0.82
PTH(1-84)/PTH(7-84): a balance of power. Am J Physiol Renal Physiol (2006) 0.80
TGF-beta3 exists in bony fish. Vet Immunol Immunopathol (1999) 0.78
The history of parathyroid hormone and its receptor: structure-based design of parathyroid hormone analogues. Osteoporos Int (1997) 0.77
Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell (2012) 4.67
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med (2009) 4.58
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem (2002) 4.52
The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med (2013) 4.32
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell (2010) 4.16
A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell (2003) 3.90
Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem (2005) 3.88
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest (2007) 3.76
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med (2012) 3.34
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature (2010) 2.78
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med (2013) 2.74
Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A (2008) 2.65
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem (2008) 2.55
Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circ Res (2007) 2.32
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev (2002) 2.31
Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev (2008) 2.22
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature (2013) 2.22
BMP signaling in skeletal development. Biochem Biophys Res Commun (2005) 2.13
GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. J Cell Biol (2004) 1.98
Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet (2012) 1.91
Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J Bone Miner Res (2011) 1.89
Endofin acts as a Smad anchor for receptor activation in BMP signaling. J Cell Sci (2007) 1.81
Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. J Orthop Res (2009) 1.76
Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell (2009) 1.72
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovasc Res (2012) 1.71
Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone (2005) 1.68
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem (2004) 1.64
Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. J Bone Miner Res (2002) 1.61
Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling. Cell Stem Cell (2010) 1.60
Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J Biol Chem (2007) 1.53
Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest (2014) 1.53
Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proc Natl Acad Sci U S A (2011) 1.48
Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep (2002) 1.42
Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling. J Bone Miner Res (2008) 1.42
Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest (2008) 1.38
A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J Immunol (2006) 1.36
Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci U S A (2007) 1.36
IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res (2007) 1.32
Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect. Mol Ther (2010) 1.30
Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. J Clin Invest (2010) 1.30
Mode of growth hormone action in osteoblasts. J Biol Chem (2007) 1.27
A mouse model for human osteogenesis imperfecta type VI. J Bone Miner Res (2013) 1.27
Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci (2010) 1.27
A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells. EMBO Rep (2003) 1.27
Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling. J Bone Miner Res (2012) 1.22
BMP signaling and skeletogenesis. Ann N Y Acad Sci (2006) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol (2012) 1.21
CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum. Plant Mol Biol (2014) 1.20
Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling. J Mol Med (Berl) (2009) 1.20
Smads oppose Hox transcriptional activities. Exp Cell Res (2006) 1.15
Multiplicity of BMP signaling in skeletal development. Ann N Y Acad Sci (2007) 1.15
The skeleton as an endocrine organ. Nat Rev Rheumatol (2012) 1.13
Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. J Cell Biochem (2010) 1.12
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. J Biol Chem (2004) 1.11
Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. J Bone Miner Res (2009) 1.11
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett (2008) 1.11
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest (2015) 1.10
A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling. J Biol Chem (2001) 1.09
Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2alpha. Endocrinology (2002) 1.09
Injury-activated transforming growth factor β controls mobilization of mesenchymal stem cells for tissue remodeling. Stem Cells (2012) 1.08
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling. J Clin Invest (2014) 1.08
Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. PLoS One (2013) 1.08
Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. J Biol Chem (2002) 1.07
Smad4 as a transcription corepressor for estrogen receptor alpha. J Biol Chem (2003) 1.07
Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop. J Bone Miner Res (2013) 1.06
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology (2013) 1.05
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells. J Appl Physiol (1985) (2006) 1.05
Mineralization and bone resorption are regulated by the androgen receptor in male mice. J Bone Miner Res (2009) 1.04
Oxygen sensing and osteogenesis. Ann N Y Acad Sci (2007) 1.04
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J Biol Chem (2008) 1.03
Paracrine overexpression of IGFBP-4 in osteoblasts of transgenic mice decreases bone turnover and causes global growth retardation. J Bone Miner Res (2003) 1.03
IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res (2011) 1.02
Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells. Adv Mater (2012) 1.02
LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s). Sci Signal (2011) 1.02
Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells. Biomaterials (2011) 1.02
Reliability and validity of the Repeatable Battery for the Assessment of Neuropsychological Status in community-dwelling elderly. Arch Med Sci (2011) 1.02
The effect of thiazolidinediones on BMD and osteoporosis. Nat Clin Pract Endocrinol Metab (2008) 1.02
Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response. J Biol Chem (2011) 1.01
Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption. J Biol Chem (2007) 1.01
Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling. Mol Endocrinol (2010) 0.99
Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res (2013) 0.98