Published in Pediatr Diabetes on June 01, 2008
Stopping type 1 diabetes: attempts to prevent or cure type 1 diabetes in man. Diabetes (2011) 1.77
Polylactide-cyclosporin A nanoparticles for targeted immunosuppression. FASEB J (2010) 0.94
Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes. Hum Vaccin (2011) 0.89
A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice. Mol Ther (2010) 0.89
The immunotherapeutic potential of dendritic cells in type 1 diabetes. Clin Exp Immunol (2010) 0.84
Protection against autoimmune diabetes by silkworm-produced GFP-tagged CTB-insulin fusion protein. Clin Dev Immunol (2011) 0.84
Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses. Math Biosci Eng (2009) 0.82
Light at the end of the tunnel? Pediatr Diabetes (2008) 0.75
In vivo delivery of nucleic acid-formulated microparticles as a potential tolerogenic vaccine for type 1 diabetes. Rev Diabet Stud (2012) 0.75
Tolerogenic immunosuppression for organ transplantation. Lancet (2003) 4.09
Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2002) 3.96
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am J Hum Genet (2008) 3.95
Screen and clean: a tool for identifying interactions in genome-wide association studies. Genet Epidemiol (2010) 2.70
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23
Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes (2004) 2.16
Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience. J Clin Endocrinol Metab (2015) 2.14
Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84
Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 1.70
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 1.65
Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes (2005) 1.64
Monocytes are progressively activated in the circulation of pregnant women. J Leukoc Biol (2002) 1.63
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol (2006) 1.58
Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Proc Natl Acad Sci U S A (2006) 1.46
Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes (2006) 1.45
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38
Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes (2005) 1.27
Clinical islet xenotransplantation: how close are we? Diabetes (2012) 1.26
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes (2002) 1.23
Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol (2011) 1.21
Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. J Immunol (2007) 1.19
Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates. J Biol Chem (2001) 1.18
Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes (2002) 1.17
Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells. Atherosclerosis (2008) 1.17
Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol (2004) 1.16
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes (2003) 1.15
The role of external and matrix pH in mitochondrial reactive oxygen species generation. J Biol Chem (2008) 1.13
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem (2003) 1.12
Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies. Stat Med (2010) 1.11
Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS One (2010) 1.10
Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol (2009) 1.10
Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes (2006) 1.10
Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements. Genome Res (2005) 1.09
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes (2003) 1.08
Immunosuppressive effects of glucosamine. J Biol Chem (2002) 1.08
Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells (2003) 1.07
Suppression of autoimmune diabetes by soluble galectin-1. J Immunol (2009) 1.06
Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein. Biotechniques (2003) 1.02
Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies. Xenotransplantation (2007) 1.02
Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation. Am J Transplant (2005) 1.01
A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes (2008) 1.01
Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation (2007) 0.99
Redox modulation protects islets from transplant-related injury. Diabetes (2010) 0.98
Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol (2006) 0.98
Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes (2010) 0.97
Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses. Pancreas (2006) 0.95
Lessons of organ-induced tolerance learned from historical clinical experience. Transplantation (2004) 0.94
The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation. J Biomed Res (2013) 0.93
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther (2008) 0.93
Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology (2010) 0.92
Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation. Diabetes (2008) 0.92
Facilitating physiologic self-regeneration: a step beyond islet cell replacement. Pharm Res (2006) 0.92
Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same? Clin Dev Immunol (2011) 0.92
Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated? Cell Transplant (2012) 0.91
Multifaceted therapeutic approaches for a multigenic disease. Diabetes (2005) 0.91
Proteomic analysis of fructose-induced fatty liver in hamsters. Metabolism (2008) 0.89
Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans. Exp Diabesity Res (2004) 0.89
Four-color flow cytometric analysis of peripheral blood donor cell chimerism. Hum Immunol (2003) 0.89
FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival. Mol Endocrinol (2012) 0.88
Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children. Rev Diabet Stud (2007) 0.88
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Ann N Y Acad Sci (2007) 0.87
Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels. Am J Physiol Endocrinol Metab (2007) 0.87
Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis. PLoS Comput Biol (2012) 0.87
Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes (2012) 0.87
Pyrosequencing-based strategies for improved allele typing of human leukocyte antigen loci. Methods Mol Biol (2007) 0.87
Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted? Xenotransplantation (2013) 0.86
Pig-to-nonhuman primates pancreatic islet xenotransplantation: an overview. Curr Diab Rep (2011) 0.86
Rehabilitation of adaptive immunity and regeneration of beta cells. Trends Biotechnol (2006) 0.86
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival. Am J Physiol Heart Circ Physiol (2007) 0.86
Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus. Pediatr Endocrinol Rev (2008) 0.86
It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes (2014) 0.85
Y Chromosomal Sequences Identified in Gonadal Tissue of Two 45,X Patients with Turner Syndrome. Endocr Pathol (1995) 0.85
Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes. Adv Drug Deliv Rev (2007) 0.85
A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes (2012) 0.84
Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. J Biol Chem (2002) 0.84
SOP3: a web-based tool for selection of oligonucleotide primers for single nucleotide polymorphism analysis by Pyrosequencing. Biotechniques (2005) 0.84
Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation. J Transplant (2011) 0.83
Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis. J Transplant (2012) 0.83
Islet cell autoimmunity in a triethnic adult population of the Third National Health and Nutrition Examination Survey. Diabetes (2004) 0.83
HLA class II DRB high resolution genotyping by pyrosequencing: comparison of group specific PCR and pyrosequencing primers. Hum Immunol (2004) 0.83
Suppression of memory CD8 T cell generation and function by tryptophan catabolism. J Immunol (2007) 0.83
Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreata. Am J Transplant (2003) 0.83
Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes. J Clin Endocrinol Metab (2015) 0.82
Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility. Diabetes (2006) 0.82
Glucose metabolism in pigs expressing human genes under an insulin promoter. Xenotransplantation (2014) 0.82
Dendritic cell-based therapy in Type 1 diabetes mellitus. Expert Rev Clin Immunol (2009) 0.82
Islet xenotransplantation: what is the optimal age of the islet-source pig? Xenotransplantation (2014) 0.82
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem (2012) 0.82
Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells. Cell Immunol (2012) 0.81
Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation. Transplantation (2007) 0.81
Gene therapy for type 1 diabetes: a proposal to move to the next level. Curr Opin Mol Ther (2005) 0.80
Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model. Cell Mol Immunol (2012) 0.80
Increased yield and improved transplantation outcome of mouse islets with bovine serum albumin. J Transplant (2012) 0.80
Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab (2011) 0.80
Islet xenotransplantation from genetically engineered pigs. Curr Opin Organ Transplant (2013) 0.80
HLA matching and the point system. Clin Transplant (1993) 0.80
Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis. Biol Reprod (2003) 0.80
C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflamm Res (2011) 0.79