Published in Cell Stem Cell on October 11, 2007
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Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
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Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
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Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
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A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
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Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
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Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
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DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
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HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 7.57
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
A more efficient method to generate integration-free human iPS cells. Nat Methods (2011) 7.39
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Retracted Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2004) 7.21
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc (2007) 7.01
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
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A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell (2008) 5.99
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
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Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell (2007) 5.29
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Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
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Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell (2009) 4.38
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr Biol (2008) 4.34
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell (2011) 4.29
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell (2004) 3.94
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet (2009) 3.73
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol (2004) 3.72