1
|
Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution.
|
Genetics
|
2005
|
3.98
|
2
|
Evolutionary conservation of expression profiles between human and mouse orthologous genes.
|
Mol Biol Evol
|
2005
|
3.62
|
3
|
Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov.
|
J Clin Microbiol
|
2003
|
3.59
|
4
|
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.
|
Nat Rev Genet
|
2011
|
3.57
|
5
|
Why do hubs tend to be essential in protein networks?
|
PLoS Genet
|
2006
|
3.29
|
6
|
Gene losses during human origins.
|
PLoS Biol
|
2006
|
3.17
|
7
|
RNA sequencing shows no dosage compensation of the active X-chromosome.
|
Nat Genet
|
2010
|
2.71
|
8
|
Null mutations in human and mouse orthologs frequently result in different phenotypes.
|
Proc Natl Acad Sci U S A
|
2008
|
2.60
|
9
|
Balanced codon usage optimizes eukaryotic translational efficiency.
|
PLoS Genet
|
2012
|
2.32
|
10
|
Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteins.
|
Mol Biol Evol
|
2006
|
2.22
|
11
|
Genomic patterns of pleiotropy and the evolution of complexity.
|
Proc Natl Acad Sci U S A
|
2010
|
2.19
|
12
|
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks.
|
Nat Genet
|
2010
|
2.16
|
13
|
Mouse duplicate genes are as essential as singletons.
|
Trends Genet
|
2007
|
2.12
|
14
|
More genes underwent positive selection in chimpanzee evolution than in human evolution.
|
Proc Natl Acad Sci U S A
|
2007
|
2.00
|
15
|
Low rates of expression profile divergence in highly expressed genes and tissue-specific genes during mammalian evolution.
|
Mol Biol Evol
|
2006
|
1.97
|
16
|
Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.
|
Proc Natl Acad Sci U S A
|
2005
|
1.88
|
17
|
Toward a molecular understanding of pleiotropy.
|
Genetics
|
2006
|
1.88
|
18
|
Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land.
|
Genome Res
|
2007
|
1.85
|
19
|
Adaptive diversification of bitter taste receptor genes in Mammalian evolution.
|
Mol Biol Evol
|
2003
|
1.82
|
20
|
Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes.
|
Mol Biol Evol
|
2005
|
1.77
|
21
|
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells.
|
Int J Cancer
|
2006
|
1.76
|
22
|
The hearing gene Prestin unites echolocating bats and whales.
|
Curr Biol
|
2010
|
1.62
|
23
|
Higher duplicability of less important genes in yeast genomes.
|
Mol Biol Evol
|
2005
|
1.57
|
24
|
Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo.
|
Mol Biol Evol
|
2010
|
1.53
|
25
|
Maintenance of duplicate genes and their functional redundancy by reduced expression.
|
Trends Genet
|
2010
|
1.51
|
26
|
Composition and evolution of the V2r vomeronasal receptor gene repertoire in mice and rats.
|
Genomics
|
2005
|
1.47
|
27
|
Impact of gene expression noise on organismal fitness and the efficacy of natural selection.
|
Proc Natl Acad Sci U S A
|
2011
|
1.46
|
28
|
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories.
|
Genomics
|
2005
|
1.43
|
29
|
Sex-specific splicing of the honeybee doublesex gene reveals 300 million years of evolution at the bottom of the insect sex-determination pathway.
|
Genetics
|
2007
|
1.43
|
30
|
Gene complexity and gene duplicability.
|
Curr Biol
|
2005
|
1.42
|
31
|
In search of the biological significance of modular structures in protein networks.
|
PLoS Comput Biol
|
2007
|
1.38
|
32
|
Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes.
|
Hum Mol Genet
|
2004
|
1.38
|
33
|
The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast.
|
Cell Rep
|
2012
|
1.36
|
34
|
Evolution of the sweet taste receptor gene Tas1r2 in bats.
|
Mol Biol Evol
|
2010
|
1.36
|
35
|
Impact of translational error-induced and error-free misfolding on the rate of protein evolution.
|
Mol Syst Biol
|
2010
|
1.35
|
36
|
Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates.
|
Mol Biol Evol
|
2008
|
1.33
|
37
|
Measuring the evolutionary rate of protein-protein interaction.
|
Proc Natl Acad Sci U S A
|
2011
|
1.32
|
38
|
MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3.
|
Cancer Lett
|
2013
|
1.31
|
39
|
Positive selection for elevated gene expression noise in yeast.
|
Mol Syst Biol
|
2009
|
1.30
|
40
|
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly.
|
Proc Natl Acad Sci U S A
|
2012
|
1.29
|
41
|
Genomic and genetic evidence for the loss of umami taste in bats.
|
Genome Biol Evol
|
2011
|
1.27
|
42
|
Did brain-specific genes evolve faster in humans than in chimpanzees?
|
Trends Genet
|
2006
|
1.26
|
43
|
Positive selection on protein-length in the evolution of a primate sperm ion channel.
|
Proc Natl Acad Sci U S A
|
2003
|
1.26
|
44
|
Gene dosage and gene duplicability.
|
Genetics
|
2008
|
1.23
|
45
|
Abundant indispensable redundancies in cellular metabolic networks.
|
Genome Biol Evol
|
2009
|
1.23
|
46
|
Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation.
|
Proc Natl Acad Sci U S A
|
2012
|
1.22
|
47
|
Rapid turnover and species-specificity of vomeronasal pheromone receptor genes in mice and rats.
|
Gene
|
2004
|
1.21
|
48
|
p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR.
|
Mol Cancer Ther
|
2008
|
1.21
|
49
|
Genomic evidence for elevated mutation rates in highly expressed genes.
|
EMBO Rep
|
2012
|
1.19
|
50
|
Largest vertebrate vomeronasal type 1 receptor gene repertoire in the semiaquatic platypus.
|
Mol Biol Evol
|
2007
|
1.19
|
51
|
Why are some human disease-associated mutations fixed in mice?
|
Trends Genet
|
2003
|
1.19
|
52
|
Why is the correlation between gene importance and gene evolutionary rate so weak?
|
PLoS Genet
|
2009
|
1.16
|
53
|
On the definition and measurement of pleiotropy.
|
Trends Genet
|
2013
|
1.14
|
54
|
Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesis.
|
Mol Biol Evol
|
2008
|
1.13
|
55
|
No gene-specific optimization of mutation rate in Escherichia coli.
|
Mol Biol Evol
|
2013
|
1.13
|
56
|
Coexpression of linked genes in Mammalian genomes is generally disadvantageous.
|
Mol Biol Evol
|
2008
|
1.12
|
57
|
Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in mice.
|
Mol Biol Evol
|
2004
|
1.11
|
58
|
Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer.
|
Int J Cancer
|
2007
|
1.10
|
59
|
Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.
|
Proc Natl Acad Sci U S A
|
2013
|
1.09
|
60
|
Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire.
|
Mol Biol Evol
|
2013
|
1.08
|
61
|
Positive selection for indel substitutions in the rodent sperm protein catsper1.
|
Mol Biol Evol
|
2005
|
1.07
|
62
|
Contrasting genetic paths to morphological and physiological evolution.
|
Proc Natl Acad Sci U S A
|
2010
|
1.05
|
63
|
Evolution of the complementary sex-determination gene of honey bees: balancing selection and trans-species polymorphisms.
|
Genome Res
|
2006
|
1.04
|
64
|
Impact of extracellularity on the evolutionary rate of mammalian proteins.
|
Genome Biol Evol
|
2010
|
1.02
|
65
|
Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer.
|
Cancer Lett
|
2008
|
1.02
|
66
|
The ortholog conjecture is untestable by the current gene ontology but is supported by RNA sequencing data.
|
PLoS Comput Biol
|
2012
|
1.02
|
67
|
High expression hampers horizontal gene transfer.
|
Genome Biol Evol
|
2012
|
1.01
|
68
|
Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae).
|
J Med Entomol
|
2003
|
1.01
|
69
|
Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library.
|
Int J Cancer
|
2004
|
1.01
|
70
|
Remarkable expansions of an X-linked reproductive homeobox gene cluster in rodent evolution.
|
Genomics
|
2006
|
1.00
|
71
|
Evolutionary dynamics of nematode operons: easy come, slow go.
|
Genome Res
|
2008
|
1.00
|
72
|
Protein subcellular relocalization in the evolution of yeast singleton and duplicate genes.
|
Genome Biol Evol
|
2009
|
0.99
|
73
|
Human coding RNA editing is generally nonadaptive.
|
Proc Natl Acad Sci U S A
|
2014
|
0.96
|
74
|
Zebrafish ribonucleases are bactericidal: implications for the origin of the vertebrate RNase A superfamily.
|
Mol Biol Evol
|
2007
|
0.95
|
75
|
Rapid evolution of mammalian X-linked testis-expressed homeobox genes.
|
Genetics
|
2004
|
0.93
|
76
|
Evidence for escape from adaptive conflict?
|
Nature
|
2009
|
0.91
|
77
|
Diagnosis of gastric cancer using decision tree classification of mass spectral data.
|
Cancer Sci
|
2007
|
0.90
|
78
|
Origin and evolution of the vertebrate vomeronasal system viewed through system-specific genes.
|
Bioessays
|
2006
|
0.90
|
79
|
A big world inside small-world networks.
|
PLoS One
|
2009
|
0.90
|
80
|
Widespread losses of vomeronasal signal transduction in bats.
|
Mol Biol Evol
|
2010
|
0.89
|
81
|
Processed pseudogenes: the 'fossilized footprints' of past gene expression.
|
Trends Genet
|
2009
|
0.89
|
82
|
Ancient expansion of the ribonuclease A superfamily revealed by genomic analysis of placental and marsupial mammals.
|
Gene
|
2006
|
0.88
|
83
|
Genetic evidence for the coexistence of pheromone perception and full trichromatic vision in howler monkeys.
|
Mol Biol Evol
|
2004
|
0.85
|
84
|
Mismatches between feeding ecology and taste receptor evolution: an inconvenient truth.
|
Proc Natl Acad Sci U S A
|
2012
|
0.85
|
85
|
Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon?
|
Genetics
|
2005
|
0.84
|
86
|
Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity.
|
Microbes Infect
|
2010
|
0.84
|
87
|
Elevated maspin expression is associated with better overall survival in esophageal squamous cell carcinoma (ESCC).
|
PLoS One
|
2013
|
0.84
|
88
|
Genome-wide evolutionary conservation of N-glycosylation sites.
|
Mol Biol Evol
|
2011
|
0.84
|
89
|
Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents.
|
J Mol Evol
|
2004
|
0.83
|
90
|
Positive selection, not negative selection, in the pseudogenization of rcsA in Yersinia pestis.
|
Proc Natl Acad Sci U S A
|
2008
|
0.83
|
91
|
IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis.
|
PLoS One
|
2012
|
0.82
|
92
|
Rapid evolution of primate ESX1, an X-linked placenta- and testis-expressed homeobox gene.
|
Hum Mol Genet
|
2007
|
0.82
|
93
|
Preparation and characterization of monoclonal antibodies against nucleostemin, a protein that controls cell proliferation in stem cells and cancer cells.
|
Hybridoma (Larchmt)
|
2005
|
0.81
|
94
|
Accelerated evolution and loss of a domain of the sperm-egg-binding protein SED1 in ancestral primates.
|
Mol Biol Evol
|
2006
|
0.80
|
95
|
Phylogenetic evidence for parallel adaptive origins of digestive RNases in Asian and African leaf monkeys: a response to Xu et al. (2009).
|
Mol Phylogenet Evol
|
2009
|
0.79
|
96
|
Why are genes encoded on the lagging strand of the bacterial genome?
|
Genome Biol Evol
|
2013
|
0.79
|
97
|
Toward genome-wide identification of Bateson-Dobzhansky-Muller incompatibilities in yeast: a simulation study.
|
Genome Biol Evol
|
2013
|
0.78
|
98
|
On the growth of scientific knowledge: yeast biology as a case study.
|
PLoS Comput Biol
|
2009
|
0.78
|
99
|
The microevolution of V1r vomeronasal receptor genes in mice.
|
Genome Biol Evol
|
2011
|
0.77
|
100
|
Accuracy and application of the motif expression decomposition method in dissecting transcriptional regulation.
|
Nucleic Acids Res
|
2008
|
0.76
|
101
|
Phylostratigraphic Bias Creates Spurious Patterns of Genome Evolution.
|
Mol Biol Evol
|
2016
|
0.76
|
102
|
Erratic evolution of SRY in higher primates.
|
Mol Biol Evol
|
2002
|
0.76
|
103
|
A panorama of mammalian gene expression evolution.
|
Mol Syst Biol
|
2011
|
0.76
|
104
|
Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2.
|
Oncol Rep
|
2012
|
0.75
|
105
|
Important genomic regions mutate less often than do other regions.
|
Nature
|
2022
|
0.75
|