Published in DNA Repair (Amst) on May 09, 2008
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell (2010) 3.51
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature (2015) 2.04
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature (2013) 1.57
Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila. PLoS Genet (2010) 1.55
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A (2010) 1.48
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet (2014) 1.33
Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans. Genome Res (2014) 1.22
DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair (Amst) (2012) 1.21
Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links. Biochemistry (2009) 1.06
Promiscuous DNA synthesis by human DNA polymerase θ. Nucleic Acids Res (2011) 1.02
Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle. Environ Mol Mutagen (2010) 0.99
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Res (2011) 0.90
Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer. Antioxid Redox Signal (2012) 0.89
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nat Commun (2013) 0.89
Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res (2013) 0.85
Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures. J Biol Chem (2011) 0.83
Linking DNA polymerase theta structure and function in health and disease. Cell Mol Life Sci (2015) 0.81
Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans. Genetics (2016) 0.79
Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin. Worm (2013) 0.78
Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining. PLoS Genet (2016) 0.77
A DOG's View of Fanconi Anemia: Insights from C. elegans. Anemia (2012) 0.77
DNA Polymerase θ: A Unique Multifunctional End-Joining Machine. Genes (Basel) (2016) 0.76
A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study. BMC Cancer (2014) 0.76
A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage. Nucleic Acids Res (2016) 0.75
JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity. PLoS Genet (2017) 0.75
Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair. PLoS Genet (2017) 0.75
Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites. Breast Cancer Res Treat (2014) 0.75
Microhomology-mediated end joining: new players join the team. Cell Biosci (2017) 0.75
A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. Elife (2017) 0.75
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell (2013) 3.05
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell (2010) 2.91
Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet (2010) 2.66
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. EMBO J (2006) 2.41
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science (2012) 2.39
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem (2005) 2.27
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell (2004) 2.26
RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell (2012) 2.24
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol (2002) 2.06
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol (2007) 2.04
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Mol Cell (2013) 1.97
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair. Mol Cell (2010) 1.90
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J (2008) 1.89
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol (2007) 1.77
HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis. Dev Cell (2008) 1.76
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res (2003) 1.76
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol (2005) 1.74
RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell (2012) 1.74
RTEL-1 enforces meiotic crossover interference and homeostasis. Science (2010) 1.70
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev (2008) 1.68
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J (2004) 1.65
DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc Natl Acad Sci U S A (2006) 1.64
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature (2013) 1.57
BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair. J Cell Sci (2012) 1.55
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol (2008) 1.54
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Mol Cell Biol (2007) 1.53
Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates. PLoS Genet (2009) 1.52
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell (2010) 1.51
The choice in meiosis - defining the factors that influence crossover or non-crossover formation. J Cell Sci (2011) 1.49
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res (2007) 1.48
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet (2010) 1.45
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell (2013) 1.44
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. J Mol Biol (2006) 1.42
Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation. Mol Cell (2010) 1.33
The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. J Biol Chem (2005) 1.31
Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2. Proc Natl Acad Sci U S A (2007) 1.30
Replication blocking lesions present a unique substrate for homologous recombination. EMBO J (2007) 1.29
The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci (2012) 1.27
RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination. Nucleic Acids Res (2010) 1.27
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science (2013) 1.21
Loss and gain of domains during evolution of cut superclass homeobox genes. Int J Dev Biol (2002) 1.20
Checkpoint mechanisms at the intersection between DNA damage and repair. DNA Repair (Amst) (2009) 1.18
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet (2009) 1.14
C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair. DNA Repair (Amst) (2006) 1.14
Tandem immunoaffinity purification of protein complexes from Caenorhabditis elegans. Biotechniques (2004) 1.13
Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet (2010) 1.12
Emerging links between the biological clock and the DNA damage response. Chromosoma (2007) 1.12
Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1. DNA Repair (Amst) (2006) 1.11
Meiotic recombination in Caenorhabditis elegans. Chromosome Res (2007) 1.08
Hedgehogs, humans and high-school science. The benefits of involving high-school students in university research. EMBO Rep (2008) 1.08
One-step high-throughput assay for quantitative detection of beta-galactosidase activity in intact gram-negative bacteria, yeast, and mammalian cells. Biotechniques (2006) 1.07
Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. PLoS Genet (2013) 1.06
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
Mind the gap: keeping UV lesions in check. DNA Repair (Amst) (2011) 1.05
Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation. Proc Natl Acad Sci U S A (2011) 1.02
The DNA polymerase alpha-primase complex: multiple functions and interactions. ScientificWorldJournal (2003) 0.99
Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. EMBO Rep (2006) 0.98
BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair. EMBO Rep (2008) 0.97
Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. PLoS Genet (2010) 0.96
Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers. Neurobiol Dis (2010) 0.96
Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε. PLoS Genet (2011) 0.95
NER and DDR: classical music with new instruments. Cell Cycle (2012) 0.94
The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans. EMBO J (2009) 0.93
C. elegans: a model of Fanconi anemia and ICL repair. Mutat Res (2008) 0.92
Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development. EMBO J (2006) 0.91
Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. J Biol Chem (2013) 0.89
Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics (2009) 0.89
A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A (2002) 0.89
BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg? DNA Repair (Amst) (2006) 0.89
The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling. Cell Cycle (2014) 0.88
Yeast haspin kinase regulates polarity cues necessary for mitotic spindle positioning and is required to tolerate mitotic arrest. Dev Cell (2013) 0.83
Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle (2006) 0.83
Metabolism of postsynaptic recombination intermediates. FEBS Lett (2010) 0.82
Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. DNA Repair (Amst) (2010) 0.82
To trim or not to trim: progression and control of DSB end resection. Cell Cycle (2013) 0.82
High-throughput expression, purification, and characterization of recombinant Caenorhabditis elegans proteins. Biochem Biophys Res Commun (2003) 0.81
Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis. J Biol Chem (2009) 0.81
DNA decay and limited Rad53 activation after liquid holding of UV-treated nucleotide excision repair deficient S. cerevisiae cells. DNA Repair (Amst) (2004) 0.80
In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae. BMC Syst Biol (2013) 0.78
The LIM homeobox gene ceh-14 is required for phasmid function and neurite outgrowth. Dev Biol (2013) 0.78
FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway. Cell Cycle (2009) 0.78
FANCM: fork pause, rewind and play. EMBO J (2010) 0.77
DNA repair: Decision at the break point. Nature (2010) 0.77
Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1. J Biol Chem (2003) 0.77
Helicase and translocases required for the maintenance of genome stability. DNA Repair (Amst) (2010) 0.77