Published in Nat Cell Biol on March 25, 2007
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RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol (2007) 3.61
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev (2010) 1.98
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ATR activation and replication fork restart are defective in FANCM-deficient cells. EMBO J (2010) 1.75
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell (2009) 1.64
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem (2010) 1.56
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Mol Cell Biol (2007) 1.53
PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem (2009) 1.50
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FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J (2009) 1.31
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Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem (2009) 1.22
Emerging links between the biological clock and the DNA damage response. Chromosoma (2007) 1.12
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev (2008) 1.12
Targeting the checkpoint kinase Chk1 in cancer therapy. Cell Cycle (2010) 1.11
Fanconi anemia proteins and endogenous stresses. Mutat Res (2009) 1.11
The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis (2009) 1.05
PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest (2012) 1.04
Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proc Natl Acad Sci U S A (2015) 1.02
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA. Mutat Res (2009) 0.99
Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development. PLoS Genet (2009) 0.98
Roles of human AND-1 in chromosome transactions in S phase. J Biol Chem (2009) 0.95
LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS One (2012) 0.94
Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2. Nucleus (2012) 0.94
Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. Cell Death Dis (2011) 0.89
Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins. J Virol (2012) 0.89
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. Hum Mol Genet (2011) 0.89
ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions. Cancer Res (2013) 0.88
The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling. Cell Cycle (2014) 0.88
Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor. Oncogene (2011) 0.87
Cell cycle progression in response to oxygen levels. Cell Mol Life Sci (2014) 0.82
Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes Dev (2015) 0.82
Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis. Cell Cycle (2009) 0.82
Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract. J Biol Chem (2012) 0.81
Mec1 function in the DNA damage response does not require its interaction with Tel2. Cell Cycle (2008) 0.81
FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents. Oncotarget (2014) 0.79
Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling. PLoS One (2012) 0.78
Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families. Fam Cancer (2010) 0.77
Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks. Biochim Biophys Acta (2011) 0.77
Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae. PLoS One (2012) 0.77
Alterations in DNA repair gene expression and their possible regulation in rat-liver regeneration. Genet Mol Biol (2011) 0.75
Overexpression of TELO2 decreases survival in human high-grade gliomas. Oncotarget (2016) 0.75
Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res (2017) 0.75
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat Methods (2013) 3.59
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell (2013) 3.05
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell (2010) 2.91
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. EMBO J (2006) 2.41
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science (2012) 2.39
RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell (2012) 2.24
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol (2002) 2.06
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Mol Cell (2013) 1.97
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair. Mol Cell (2010) 1.90
HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis. Dev Cell (2008) 1.76
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol (2005) 1.74
RTEL-1 enforces meiotic crossover interference and homeostasis. Science (2010) 1.70
ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol (2005) 1.70
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev (2008) 1.68
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature (2013) 1.57
BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair. J Cell Sci (2012) 1.55
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Mol Cell Biol (2007) 1.53
BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Curr Biol (2004) 1.52
Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates. PLoS Genet (2009) 1.52
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell (2010) 1.51
The choice in meiosis - defining the factors that influence crossover or non-crossover formation. J Cell Sci (2011) 1.49
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol Med (2009) 1.49
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res (2007) 1.48
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. J Mol Biol (2006) 1.42
E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation. Blood (2006) 1.37
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways. DNA Repair (Amst) (2008) 1.33
Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2. Proc Natl Acad Sci U S A (2007) 1.30
Replication blocking lesions present a unique substrate for homologous recombination. EMBO J (2007) 1.29
The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci (2012) 1.27
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. DNA Repair (Amst) (2007) 1.27
RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination. Nucleic Acids Res (2010) 1.27
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science (2013) 1.21
Activation of the Cpx envelope stress response down-regulates expression of several locus of enterocyte effacement-encoded genes in enteropathogenic Escherichia coli. Infect Immun (2008) 1.20
C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair. DNA Repair (Amst) (2006) 1.14
Tandem immunoaffinity purification of protein complexes from Caenorhabditis elegans. Biotechniques (2004) 1.13
Emerging links between the biological clock and the DNA damage response. Chromosoma (2007) 1.12
Nuclear hormone receptors in nematodes: evolution and function. Mol Cell Endocrinol (2010) 1.08
Meiotic recombination in Caenorhabditis elegans. Chromosome Res (2007) 1.08
Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. PLoS Genet (2013) 1.06
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study. Clin Cancer Res (2013) 0.99
Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. EMBO Rep (2006) 0.98
BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair. EMBO Rep (2008) 0.97
The genomic landscape of oesophagogastric junctional adenocarcinoma. J Pathol (2013) 0.95
Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links. Mol Cell Biol (2003) 0.93
The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans. EMBO J (2009) 0.93
C. elegans: a model of Fanconi anemia and ICL repair. Mutat Res (2008) 0.92
BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg? DNA Repair (Amst) (2006) 0.89
Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. J Biol Chem (2013) 0.89
Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics (2009) 0.89
The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling. Cell Cycle (2014) 0.88
Metabolism of postsynaptic recombination intermediates. FEBS Lett (2010) 0.82
High-throughput expression, purification, and characterization of recombinant Caenorhabditis elegans proteins. Biochem Biophys Res Commun (2003) 0.81
Generation of a restriction minus enteropathogenic Escherichia coli E2348/69 strain that is efficiently transformed with large, low copy plasmids. BMC Microbiol (2008) 0.80
FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway. Cell Cycle (2009) 0.78
FANCM: fork pause, rewind and play. EMBO J (2010) 0.77
DNA repair: Decision at the break point. Nature (2010) 0.77
Helicase and translocases required for the maintenance of genome stability. DNA Repair (Amst) (2010) 0.77
DNA repair: A heavyweight joins the fray. Nature (2009) 0.76
Differential regulation of the PIKK kinase family by Tel2. Cell Cycle (2008) 0.76
Multiple modality treatment regimen in an aggressive resistant fungal hand infection: a case report. Hand (N Y) (2010) 0.75
How to exchange your partner. Workshop on recombination mechanisms and the maintenance of genomic stability. EMBO Rep (2006) 0.75
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility. Cell Rep (2016) 0.75
TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding. Mol Cell (2016) 0.75
Erratum: Molecular basis of telomere dysfunction in human genetic diseases. Nat Struct Mol Biol (2017) 0.75