Published in Mol Hum Reprod on May 29, 2008
p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis. Cancer Metastasis Rev (2010) 0.99
A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J (2011) 0.97
Telomere lengths in human oocytes, cleavage stage embryos and blastocysts. Mol Hum Reprod (2010) 0.90
TEAD4 establishes the energy homeostasis essential for blastocoel formation. Development (2013) 0.87
Automated microinjection of recombinant BCL-X into mouse zygotes enhances embryo development. PLoS One (2011) 0.85
Embryotropic actions of follistatin: paracrine and autocrine mediators of oocyte competence and embryo developmental progression. Reprod Fertil Dev (2013) 0.84
Markers of cellular senescence are elevated in murine blastocysts cultured in vitro: molecular consequences of culture in atmospheric oxygen. J Assist Reprod Genet (2014) 0.82
Assessment of three generations of mice derived by ICSI using freeze-dried sperm. Zygote (2009) 0.81
Oxidative damage to rhesus macaque spermatozoa results in mitotic arrest and transcript abundance changes in early embryos. Biol Reprod (2013) 0.81
Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles. Reprod Biol Endocrinol (2014) 0.81
The long and short of it: the role of telomeres in fetal origins of adult disease. J Pregnancy (2012) 0.80
The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. PLoS One (2014) 0.79
Release of superoxide dismutase-1 by day 3 embryos of varying quality and implantation potential. J Assist Reprod Genet (2012) 0.79
Trends, fads and ART! J Assist Reprod Genet (2015) 0.78
Nitric oxide-donor SNAP induces Xenopus eggs activation. PLoS One (2012) 0.77
Chromosomal Aneuploidies and Early Embryonic Developmental Arrest. Int J Fertil Steril (2015) 0.75
Patients with polycystic ovary syndrome have successful embryo arrest. Int J Clin Exp Med (2015) 0.75
The effects of ethanol and strontium on growth and development of two-cell arrested mouse embryos. Int J Fertil Steril (2012) 0.75
Changes in Sperm Motility and Capacitation Induce Chromosomal Aberration of the Bovine Embryo following Intracytoplasmic Sperm Injection. PLoS One (2015) 0.75
What Drives Embryo Development? Chromosomal Normality or Mitochondria? Case Rep Genet (2017) 0.75
Comparative Stepwise Pattern of Reactive Oxygen Species Production during In Vitro Development of Fertilized and Nuclear Transferred Goat Embryos. Int J Fertil Steril (2017) 0.75
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Checkpoints: controls that ensure the order of cell cycle events. Science (1989) 21.01
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell (2007) 12.33
Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19
Oxidative stress shortens telomeres. Trends Biochem Sci (2002) 9.48
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85
Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature (1999) 7.66
Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell (1992) 6.86
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
Cellular senescence in aging primates. Science (2006) 6.24
Telomerase activity in human germline and embryonic tissues and cells. Dev Genet (1996) 5.00
The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J (2001) 4.99
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science (2002) 4.88
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol (1998) 4.59
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36
Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal (2006) 4.19
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res (1995) 3.96
Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science (2007) 3.92
Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature (1988) 3.70
DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene (2007) 3.67
Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29
Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell (1995) 3.23
Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med (2006) 3.12
Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology (2005) 3.08
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A (1994) 2.55
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci U S A (2003) 2.39
The telomere hypothesis of cellular aging. Exp Gerontol (1993) 2.39
Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update (2001) 2.20
Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci U S A (1996) 2.19
p53: good cop/bad cop. Cell (2002) 2.11
Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res (1995) 2.11
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci (2004) 2.10
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res (1998) 2.09
Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci U S A (1996) 2.05
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A (1999) 2.04
Telomere lengthening early in development. Nat Cell Biol (2007) 2.02
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol (2000) 2.00
Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci (2000) 1.97
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci (2008) 1.91
Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature (1977) 1.91
Constitutive expression of the machinery for programmed cell death. J Cell Biol (1996) 1.88
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Hypertension (2005) 1.88
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem (2004) 1.86
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs. Dev Biol (2008) 1.85
Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat Biotechnol (2000) 1.84
Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Hum Reprod (2008) 1.78
Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78
Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation (2004) 1.69
Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos. Hum Reprod (2001) 1.63
Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence. Reproduction (2004) 1.56
The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. J Biol Chem (2002) 1.55
Telomere instability in the male germline. Hum Mol Genet (2005) 1.55
Hydrogen peroxide levels in mouse oocytes and early cleavage stage embryos developed in vitro or in vivo. Development (1990) 1.53
Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos. Hum Reprod (1998) 1.49
Cell death in the mammalian blastocyst. Mol Hum Reprod (1997) 1.47
The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism. J Biol Chem (2006) 1.46
Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell (2002) 1.44
Does p53 affect organismal aging? J Cell Physiol (2002) 1.37
Evidence that exposure of the telomere 3' overhang sequence induces senescence. Proc Natl Acad Sci U S A (2003) 1.37
Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J (2000) 1.35
Utilization of ribonucleotides and RNA primers by Tetrahymena telomerase. EMBO J (1995) 1.29
Oxygen-regulated gene expression in bovine blastocysts. Biol Reprod (2004) 1.26
Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radic Biol Med (1998) 1.25
REDOX regulation of early embryo development. Reproduction (2002) 1.25
Radical solutions and cultural problems: could free oxygen radicals be responsible for the impaired development of preimplantation mammalian embryos in vitro? Bioessays (1994) 1.24
Breaking news: high-speed race ends in arrest--how oncogenes induce senescence. Trends Cell Biol (2007) 1.22
Telomere length predicts embryo fragmentation after in vitro fertilization in women--toward a telomere theory of reproductive aging in women. Am J Obstet Gynecol (2005) 1.20
Alleviation of the '2-cell block' and development to the blastocyst of CF1 mouse embryos: role of amino acids, EDTA and physical parameters. Hum Reprod (1996) 1.20
Analysis of apoptosis in the preimplantation bovine embryo using TUNEL. J Reprod Fertil (1999) 1.17
Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci U S A (2004) 1.14
Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis. J Biol Chem (2003) 1.14
From cell death to embryo arrest: mathematical models of human preimplantation embryo development. Proc Natl Acad Sci U S A (2001) 1.13
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene (1999) 1.12
Mitochondrial morphology during preimplantational human embryogenesis. Hum Reprod (2000) 1.11
Apoptosis in the human embryo. Rev Reprod (1999) 1.10
An essential role for functional telomeres in mouse germ cells during fertilization and early development. Dev Biol (2002) 1.08
The telomere theory of reproductive senescence in women. Curr Opin Obstet Gynecol (2006) 1.06
Shc signaling in differentiating neural progenitor cells. Nat Neurosci (2001) 1.05
Effect of oxygen concentration on human in-vitro fertilization and embryo culture. Hum Reprod (1999) 1.05
Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review. Biochemistry (Mosc) (1997) 1.05
Cell signaling. Mitochondrial longevity pathways. Science (2007) 1.04
Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms. Mol Cell Biol (2006) 1.04
The effects of antibodies to heat shock protein 70 in fertilization and embryo development. Mol Hum Reprod (2001) 1.03
p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria. Cell Cycle (2007) 1.02
Apoptosis in the preimplantation mouse embryo: effect of strain difference and in vitro culture. Mol Reprod Dev (2002) 1.02
A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J Theor Biol (2001) 1.01
Protection against reactive oxygen species during mouse preimplantation embryo development: role of EDTA, oxygen tension, catalase, superoxide dismutase and pyruvate. Mol Reprod Dev (2001) 0.98
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice. Exp Gerontol (2006) 0.98
Apoptosis in the early bovine embryo. Zygote (2000) 0.96
Genetic regulation of embryo death and senescence. Theriogenology (2001) 0.96
Bovine oocytes and early embryos express Staufen and ELAVL RNA-binding proteins. Zygote (2008) 0.82
Analysis of bovine sexed sperm for IVF from sorting to the embryo. Theriogenology (2008) 0.78
Total serum alkaline phosphate and its isoenzymes in normal and toxemic pregnancies. Am J Obstet Gynecol (1969) 0.75
Ludwig's angina by Salmonella Typhi: a clinical dilemma. Indian J Med Microbiol (2015) 0.75
De novo transcription of thyroid hormone receptors is essential for early bovine embryo development in vitro. Reprod Fertil Dev (2017) 0.75
A review of 31 cases of malignant trophoblastic tumours. Aust N Z J Obstet Gynaecol (1972) 0.75
Primary squamous cell carcinoma of corpus uteri (a case report). Indian J Pathol Bacteriol (1967) 0.75