Published in Biochem Biophys Res Commun on June 23, 2008
SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem (2011) 1.98
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem (2008) 1.46
The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45
Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci (2012) 1.43
Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One (2008) 1.41
Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts. PLoS One (2011) 1.29
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta (2009) 1.26
Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell (2011) 1.26
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci (2010) 1.24
The role of histone deacetylases in prostate cancer. Epigenetics (2008) 1.21
Sirtuin activators and inhibitors. Biofactors (2012) 1.19
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Proc Natl Acad Sci U S A (2010) 1.19
Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling. Carcinogenesis (2009) 1.11
Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle (2009) 1.04
The multifaceted functions of sirtuins in cancer. Nat Rev Cancer (2015) 1.04
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res (2010) 1.02
Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. PLoS One (2013) 1.01
Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. PLoS One (2012) 1.00
Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS One (2012) 1.00
Sirtuin inhibitors as anticancer agents. Future Med Chem (2014) 0.98
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. PLoS One (2013) 0.98
Emerging Roles of SIRT1 in Cancer Drug Resistance. Genes Cancer (2013) 0.97
Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. Acta Pharmacol Sin (2011) 0.96
p30 DBC is a potential regulator of tumorigenesis. Cell Cycle (2009) 0.95
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27. Mol Cancer Res (2014) 0.93
Deacetylation by SIRT1 Reprograms Inflammation and Cancer. Genes Cancer (2013) 0.92
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. Cancer Prev Res (Phila) (2012) 0.90
Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J Pharmacol Exp Ther (2014) 0.90
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. PLoS One (2013) 0.88
Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86
SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. FASEB J (2009) 0.86
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. Int J Clin Exp Med (2015) 0.84
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. J Thorac Dis (2015) 0.81
Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells. PLoS One (2014) 0.81
Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells. BMC Cancer (2015) 0.80
Sirtuin functions and modulation: from chemistry to the clinic. Clin Epigenetics (2016) 0.80
The apoptotic effects of sirtuin1 inhibitor on the MCF-7 and MRC-5 cell lines. Res Pharm Sci (2013) 0.80
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Clin Exp Nephrol (2011) 0.79
A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1. Genes Cancer (2015) 0.78
SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride. Oncotarget (2016) 0.77
The effect of resveratrol on the recurrent attacks of gouty arthritis. Clin Rheumatol (2014) 0.77
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. Clin Exp Metastasis (2015) 0.76
Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents. Oncotarget (2015) 0.76
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. Int J Oncol (2014) 0.76
Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines. Int J Prev Med (2013) 0.76
Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes. Int J Nanomedicine (2015) 0.75
Decitabine enhances stem cell antigen-1 expression in cigarette smoke extract-induced emphysema in animal model. Exp Biol Med (Maywood) (2015) 0.75
Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding. Int J Biol Sci (2016) 0.75
High glucose promotes gastric cancer chemoresistance in vivo and in vitro. Mol Med Rep (2015) 0.75
SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair. Stem Cell Reports (2017) 0.75
Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan. Antimicrob Agents Chemother (2005) 2.81
Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology (2009) 2.21
An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo. Mol Endocrinol (2002) 2.08
Prevalence of genital mycoplasmas and ureaplasmas in men younger than 40 years-of-age with acute epididymitis. Int J Urol (2011) 2.08
Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun (2008) 2.08
HIV-1 nef suppression by virally encoded microRNA. Retrovirology (2004) 2.05
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation (2004) 2.00
Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer (2002) 1.94
Threat to cefixime treatment for gonorrhea. Emerg Infect Dis (2007) 1.90
Quantitative detection of Mycoplasma genitalium from first-pass urine of men with urethritis and asymptomatic men by real-time PCR. J Clin Microbiol (2002) 1.78
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet (2007) 1.76
Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones. Antimicrob Agents Chemother (2004) 1.73
MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression. J Biol Chem (2010) 1.66
The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis. Clin Infect Dis (2007) 1.64
Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency. Cardiovasc Res (2005) 1.63
MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5. J Biol Chem (2009) 1.59
Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner. J Clin Endocrinol Metab (2002) 1.57
Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells. Int J Urol (2011) 1.56
Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. J Biol Chem (2004) 1.54
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett (2009) 1.54
Assessment of the genetic component of hypertension. Am J Hypertens (2006) 1.47
Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem (2006) 1.44
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. Prostate (2010) 1.44
MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells. Cancer Lett (2011) 1.42
A prospective evaluation of the effects of salpingectomy on endometrial lymphocyte clusters in patients with hydrosalpinges. Fertil Steril (2004) 1.39
Nationwide survey of urogenital tuberculosis in Japan. Int J Urol (2014) 1.38
Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. J Mol Med (Berl) (2003) 1.37
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorg Med Chem (2005) 1.36
Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem (2004) 1.33
Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Bioorg Med Chem (2007) 1.33
Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways. Cancer Lett (2012) 1.32
Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci (2008) 1.30
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. Biochem Biophys Res Commun (2006) 1.29
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria. J Biomed Sci (2002) 1.29
Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun (2009) 1.27
Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. PLoS One (2008) 1.26
Endoscopic resection of Peutz-Jeghers polyps throughout the small intestine at double-balloon enteroscopy without laparotomy. Gastrointest Endosc (2005) 1.24
Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction. Am J Pathol (2004) 1.22
Genetic risk for ischemic and hemorrhagic stroke. Arterioscler Thromb Vasc Biol (2006) 1.21
The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. Clin Cancer Res (2002) 1.20
Prediction of genetic risk for metabolic syndrome. Atherosclerosis (2006) 1.20
Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis (2009) 1.17
Anti-oncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells. J Biol Chem (2012) 1.17
Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. J Biol Chem (2009) 1.17
GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell, monocyte, B- and NK-cell (DCML) deficiency, and myelodysplasia. Eur J Pediatr (2012) 1.17
CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis. J Immunol (2010) 1.16
Rapid detection of the mosaic structure of the Neisseria gonorrhoeae penA Gene, which is associated with decreased susceptibilities to oral cephalosporins. J Clin Microbiol (2008) 1.15
Phylogeny-based rapid identification of mycoplasmas and ureaplasmas from urethritis patients. J Clin Microbiol (2002) 1.15
Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity. Mitochondrion (2005) 1.14
Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population. Hum Genet (2007) 1.12
Guillain-Barré syndrome associated with normal or exaggerated tendon reflexes. J Neurol (2011) 1.12
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod (2003) 1.11
Women with mitochondrial haplogroup N9a are protected against metabolic syndrome. Diabetes (2007) 1.11
Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C. Carcinogenesis (2003) 1.10
Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance. Int J Antimicrob Agents (2010) 1.09
Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1. Biochim Biophys Acta (2003) 1.09
Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellular carcinoma cell lines. Biochem Biophys Res Commun (2002) 1.09
Abscess of the corpus cavernosum. Int J Infect Dis (2007) 1.09
MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug. J Pharmacol Sci (2010) 1.08
Possible role of Rho/Rhotekin signaling in mammalian septin organization. Oncogene (2005) 1.08
Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells. Carcinogenesis (2009) 1.08
Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines. Biol Pharm Bull (2003) 1.07
Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse. Semin Thromb Hemost (2002) 1.07
GnRH regulates early growth response protein 1 transcription through multiple promoter elements. Mol Endocrinol (2002) 1.06
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. Biochem Biophys Res Commun (2009) 1.06